Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Tác động của liệu pháp miễn dịch dị ứng đặc hiệu lên các chỉ số sinh học và các tham số lâm sàng ở trẻ em mắc bệnh hen suyễn: một nghiên cứu thực tế có đối chứng
Tóm tắt
Liệu pháp miễn dịch dị ứng đặc hiệu (AIT) là phương pháp điều trị duy nhất có khả năng thay đổi diễn biến tự nhiên của các bệnh dị ứng. Chúng tôi đã tiến hành điều tra hiệu quả lâm sàng của SLITOR (vắc xin được đăng ký tại Serbia cho liệu pháp miễn dịch dị ứng đặc hiệu dưới lưỡi). Trẻ em từ 7 đến 18 tuổi mắc bệnh hen suyễn và viêm mũi dị ứng đã được tuyển chọn và phân bố vào nhóm điều trị tích cực (AIT kết hợp với điều trị dược lý) hoặc nhóm đối chứng (chỉ điều trị dược lý tiêu chuẩn). Các chỉ số lâm sàng và mức độ sử dụng thuốc, chức năng phổi và FeNO thở ra đã được đo ở mức cơ bản và trong mỗi lần theo dõi. Có sự cải thiện đáng kể trong cả điểm số triệu chứng viêm mũi và hen suyễn, cũng như trong điểm số sử dụng thuốc ở nhóm SLIT. SLIT đã cho thấy ảnh hưởng quan trọng đến chức năng phổi và viêm đường thở. Dữ liệu của chúng tôi cho thấy rằng SLITOR không chỉ hiệu quả về mặt kết quả do bệnh nhân báo cáo mà còn quan sát thấy sự cải thiện chức năng phổi và giảm viêm đường thở dưới.
Từ khóa
#liệu pháp miễn dịch dị ứng đặc hiệu #hen suyễn #viêm mũi dị ứng #chỉ số sinh học #trẻ emTài liệu tham khảo
Gough H, Grabenhenrich L, Reich A, et al. Allergic multimorbidity of asthma, rhinitis and eczema over 20 years in the German birth cohort MAS. Pediatr Allergy Immunol. 2015;26:431–7.
Caminati M, Duric-Filipovic I, Arasi S, Peroni DG, Zivkovic Z, Senna G. Respiratory allergies in childhood: recent advances and future challenges. Pediatr Allergy Immunol. 2015;26:702–10.
Alduraywish SA, Lodge CJ, Campbell B, et al. The march from early life food sensitization to allergic disease: a systematic review and meta-analyses of birth cohort studies. Allergy. 2015. doi:10.1111/all.1278.
Arasi S, Passalacqua G, Caminiti L, Crisafulli G, Fiamingo C, Pajno GB. Efficacy and safety of sublingual immunotherapy in children. Expert Rev Clin Immunol. 2016;12(1):49–56.
Živković Z, Cerović S, Djurić-Filipović I, Vukašinović Z, Jocić-Stojanović J, Bajec-Opančina A. (2012). Clinical implications and facts about allergic rhinitis (AR) in children, allergic rhinitis, Prof. Marek Kowalski (Ed.), ISBN: 978-953-51-0288-5, InTech, http://www.intechopen.com/books/allergic-rhinitis/allergic-rhinitis-in-childhood-clinical-implications-and-allergen-specific-immunotherapy.
Caminati M, Dama AR, Djuric I, Montagni M, Schiappoli M, Ridolo E, Senna G, Canonica GW. Incidence and risk factors for subcutaneous immunotherapy anaphylaxis: the optimization of safety. Expert Rev Clin Immunol. 2015;11(2):233–45.
Đurić-Filipović I, Caminati M, Kostić G, Filipović Đ, Živković Z. Allergen specific sublingual immunotherapy in children with asthma and allergic rhinitis. World J Pediatr. 2016;12(3):283–90.
Živković Z, Djurić-Filipović I, Živanović S. Current issues on sublingual allergen-specific immunotherapy in children with asthma and allergic rhinitis. Srp Arh Celok Lek. 2016;144(5–6):345–50.
Passalacqua G, Canonica GW. Allergen immunotherapy: history and future developments. Immunol Allergy Clin North Am. 2016;36(1):1–12. doi:10.1016/j.iac.2015.08.001.
Jutel M, Agache I, Bonini S, Burks AW, Calderon M, Canonica W, et al. International consensus on allergy immunotherapy. J Allergy Clin Immunol. 2015;136(3):556–68. doi:10.1016/j.jaci.2015.04.047.
Bannier MA, van de Kant KD, Jobsis Q, Dompeling E. Biomarkers to predict asthma in wheezing preschool children. Clin Exp Allergy. 2015;45:1040–50.
Moschino L, Zanconato S, Bozzetto S, Baraldi E, Carraro S. Childhood asthma biomarkers: present knowledge and future steps. Paediatr Respir Rev. 2015;12:S1526–42.
Payne DN, Adcock IM, Wilson NM, Oates T, Scallan M, Bush A. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone. Am J Respir Crit Care Med. 2001;164:1376–81.
American Thoracic Society, European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide. Am J Respir Crit Care Med. 2005;171:912–30.
Dweik RA, Boggs PB, Erzurum SC, on behalf of the American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FeNO) for Clinical Applications, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FeNO) for clinical applications. Am J Respir Crit Care Med. 2011;184:602–15.
Cristescu SM, Mandon J, Harren FJ, Meriläinen P, Högman M. Methods of NO detection in exhaled breath. J Breath Res. 2013;7:017104.
Kovesi T, Kulka R, Dales R. Exhaled nitric oxide concentration is affected by age, height, and race in healthy 9- to 12-year-old children. Chest. 2008;133:169–75.
Tari MG, Mancino M, Monti G. Efficacy of sublingual immunotherapy in patients with rhinitis and asthma due to house dust mite. A double blind study. Allergol Immunopathol. 1990;18:277–84.
Hirsch T, Sahn M, Leupold W. Double blind placebo controlled study of sublingual immunotherapy with house dust mite extracts in children. Pediatr Allergy Immunol. 1997;8(1):21–7.
Vourdas D, Syrigou E, Potamianou P, Carat F, Batard T. Double -blind, placebo-controlled evaluation of sublingual immunotherapy with standardized olivepollen extract in pediatric patients with allergic rhinoconjunctivitis and mild asthma due to olive pollen sensitization. Allergy. 1998;53:662–72.
La Rosa M, Ranno C, Andre´ C, Carat F, Tosca MA, Canonica GW. Double-blind placebo-controlled evaluation of sublingual swallow immunotherapy with standardized Parietaria judaica extract in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol. 1999;104:425–32.
Pajno GB, Morabito L, Barberio G, Parmiani S. Clinical and immunologic effects of long-term sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, placebo-controlled study. Allergy. 2000;55:842–9.
Caffarelli C, Sensi LG, Marcucci F, Cavagni C. Preseasonal local allergoid immunotherapy to grass pollen in children: a double-blind, placebo-controlled, randomized trial. Allergy. 2000;55:1142–7.
Yuksel H, Tanac R, Gousseinov A, Demir E. Sublingual immunotherapy and influence on urinary leukotrienes in season al pediatric allergy. J Investig Allergol Clin Immunol. 1999;9:305–13.
Bahceciler NN, Isik U, Barlan IB, Basaran MM. Efficacy of sublingual immunotherapy in children with asthma and rhinitis: a double-blind, placebo-controlled study. Pediatr Pulmonol. 2001;32:49–55.
Bufe A, Ziegler-Kirbach E, Stoeckmann E, Heidemann P, Gehlhar K, Holland-Letz T, et al. Efficacy of sublingual swallow immunotherapy in children with severe grass pollen allergic symptoms: a double-blind placebo-controlled study. Allergy. 2004;59:498–504.
Rolinck-Werninghaus C, Wolf H, Liebke C, Baars JC, Lange J, Kopp MV, et al. A pros pective, randomized, double-blind, placebo-controlled multi-centre study on the efficacy and safety of sublingual immunotherapy (SLIT) in children with seasonal allergic rhinoconjunctivitis to grass pollen. Allergy. 2004;59:1285–93.
Stelmach I, Kaczmarek-Woz´niak J, Majak P, Olszowiec-Chlebna M, Jerzynska J. Efficacy and safety of high-doses sublingual immunotherapy in ultra-rush scheme in children allergic to grass pollen. Clin Exp Allergy. 2009;39:401–8.
Penagos M, Compalati E, Tarantini F, Baena-Cagnani R, Huerta J, Passalacqua G, et al. Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials. Ann Allergy Asthma Immunol. 2006;97:141–8.
Radulovic S, Wilson D, Calderon M, Durham S. Systematic reviews of sublingual immunotherapy (SLIT). Allergy. 2011;66:740–52.
Wilson DR, Torres LI, Durham SR. Sublingual immunotherapy for allergic rhinitis. Cochrane Database Syst Rev. 2003;2:CD002893.
Calamita Z, Saconato H, Pelá AB, Atallah AN. Efficacy of sublingual immunotherapy in asthma: systematic review of randomized-clinical trials using the Cochrane Collaboration method. Allergy. 2006;10:1162–72.
Penagos M, Passalacqua G, Compalati E, Baena-Cagnani CE, Orozco S, Pedroza A, et al. Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age. Chest. 2008;133:599–609.
Nelson H, Blaiss M, Nolte H, Wu¨rtz SØ, Andersen JS, Durham SR. Efficacy and safety of the SQ-standardized grass allergy immunotherapy tablet in mono- and polysensitized subjects. Allergy. 2013;68:252–5.
Malling HJ, Montagut A, Melac M, Patriarca G, Panzner P, Seberova E, et al. Efficacy and safety of 5-grass pollen sublingual immunotherapy tablets in patients with different clinical profiles of allergic rhinoconjunctivitis. Clin Exp Allergy. 2009;39(3):387–93.
Marogna M, Spadolini I, Massolo A, Canonica GW, Passalacqua G. Long-lasting effects of sublingual immunotherapy according to its duration: a 15-year prospective study. J Allergy Clin Immunol. 2010;126(5):969–75.
Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne E, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet. 1994;343:133–5.
Massaro AF, Mehta S, Lilly CM, Kobzik L, Reilly JJ, Drazen JM. Elevated nitric oxide concentrations in isolated lower airway gas of asthmatic subjects. Am J Respir Crit Care Med. 1996;153:1510–4.
de Arruda-Chaves E, De Conti D, Tebaldi T. Nitric oxide sera levels as an inflammatory marker in asthma. J Investig Allergol Clin Immunol. 2002;12(2):120–3.
Hung CH, Lee MY, Tsai YG, Cheng SN, Yang KD. Hyposensitization therapy reduced exhaled nitric oxide in asthmatic children with corticosteroid dependency. Acta Paediatr Taiwan. 2004;45:89–93.
Inci D, Altintas DU, Kendirli SG, Yilmaz M, Karakoc GB. The effect of specifi c immunotherapy on exhaled breath condensate nitrite levels. Allergy. 2006;61:899–900.
