Effects of morphine, lidocaine, ketamine, and morphine-lidocaine-ketamine drug combination on minimum alveolar concentration in dogs anesthetized with isoflurane

American Journal of Veterinary Research - Tập 64 Số 9 - Trang 1155-1160 - 2003
William W. Muir, Ashley J. Wiese1, Philip A. March1
1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.

Tóm tắt

AbstractObjective—To determine the effects of constant rate infusion of morphine, lidocaine, ketamine, and morphine- lidocaine-ketamine (MLK) combination on endtidal isoflurane concentration (ET-Iso) and minimum alveolar concentration (MAC) in dogs anesthetized with isoflurane and monitor depth of anesthesia by use of the bispectral index (BIS).Animals—6 adult dogs.Procedure—Each dog was anesthetized with isoflurane on 5 occasions, separated by a minimum of 7 to 10 days. Individual isoflurane MAC values were determined for each dog. Reduction in isoflurane MAC, induced by administration of morphine (3.3 µg/kg/min), lidocaine (50 µg/kg/min), ketamine (10 µg/kg/min), and MLK, was determined. Heart rate, mean arterial blood pressure, oxygen saturation as measured by pulse oximetry (SpO2), core body temperature, and BIS were monitored.Results—Mean ± SD isoflurane MAC was 1.38 ± 0.08%. Morphine, lidocaine, ketamine, and MLK significantly lowered isoflurane MAC by 48, 29, 25, and 45%, respectively. The percentage reductions in isoflurane MAC for morphine and MLK were not significantly different but were significantly greater than for lidocaine and ketamine. The SpO2, mean arterial pressure, and core body temperature were not different among groups. Heart rate was significantly decreased at isoflurane MAC during infusion of morphine and MLK. The BIS was inversely related to the ET-Iso and was significantly increased at isoflurane MAC during infusions of morphine and ketamine, compared with isoflurane alone.Conclusions and Clinical Relevance—Low infusion doses of morphine, lidocaine, ketamine, and MLK decreased isoflurane MAC in dogs and were not associated with adverse hemodynamic effects. The BIS can be used to monitor depth of anesthesia. (Am J Vet Res2003;64:1155–1160)

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Tài liệu tham khảo

10.2460/ajvr.2000.61.42

Grisneaux E, 1999, J Am Vet Med Assoc, 215, 1105, 10.2460/javma.1999.215.08.1105

10.2460/ajvr.2001.62.555

Himes RS, 1977, Anesthesiology, 47, 437, 10.1097/00000542-197711000-00010

Himes RS, 1979, Anesthesiology, 51, 131, 10.1097/00000542-197908000-00008

10.2460/javma.2000.217.346

Ko JCH, 2001, J Am Anim Hosp Assoc, 37, 411, 10.5326/15473317-37-5-411

Martin DD, 1997, Vet Surg, 26, 505, 10.1111/j.1532-950X.1997.tb00526.x

Muir WW III, 1991, J Vet Pharmacol Ther, 14, 46, 10.1111/j.1365-2885.1991.tb00803.x

Muir WW III, 1999, J Am Vet Med Assoc, 215, 1116, 10.2460/javma.1999.215.08.1116

Pypendop B, 1999, Am J Vet Res, 60, 1148, 10.2460/ajvr.1999.60.09.1148

Rawlings CA, 1983, Am J Vet Res, 44, 144

10.1053/rvsc.2000.0406

Steffey EP, 1994, J Vet Pharmacol Ther, 17, 202, 10.1111/j.1365-2885.1994.tb00234.x

Tranquilli WJ, 1984, J Vet Pharmacol Ther, 7, 23, 10.1111/j.1365-2885.1984.tb00874.x

10.2460/ajvr.2002.63.969

Wagner AE, 2002, J Am Vet Med Assoc, 221, 72, 10.2460/javma.2002.221.72

Murphy MR, 1982, Anesthesiology, 57, 489, 10.1097/00000542-198212000-00010

10.1016/S0304-3959(01)00472-9

Cherry DA, 2001, Pain, 94, 119

10.1097/00000539-200107000-00025

10.1097/00000542-200204000-00010

Kehlet H, 1993, Anesth Analg, 77, 1048, 10.1213/00000539-199311000-00030

Woolf CJ, 1993, Anesth Analg, 77, 362, 10.1213/00000539-199377020-00026

Eger EI, 1965, Anesthesiology, 26, 756, 10.1097/00000542-196511000-00010

Quasha AL, 1980, Anesthesiology, 53, 315, 10.1097/00000542-198010000-00008

Zbinden AM, 1994, Anesthesiology, 80, 253, 10.1097/00000542-199402000-00004

Zbinden AM, 1994, Anesthesiology, 80, 261, 10.1097/00000542-199402000-00005

10.1097/00000539-200005000-00021

Sigl JC, Chamoun NG. An introduction to bispectral analysis for the electroencephalogram. J Clin Monit 94;10:392-404.

10.1093/bja/aef262

10.1093/bja/aef238

Christie JM, 1992, Ann Pharmcother, 26, 1078, 10.1177/106002809202600904

Steffey EP, 1977, Am J Vet Res, 38, 1833

Stoelting RK, 1987, Philadelphia: JB Lippincott Co, 89

10.2460/ajvr.2000.61.24

Dohoo S, 1994, J Vet Pharmacol Ther, 17, 426, 10.1111/j.1365-2885.1994.tb00273.x

Dohoo S, 1997, Can J Vet Res, 61, 251

Butterworth JF IV, 1990, Anesthesiology, 72, 711, 10.1097/00000542-199004000-00022

10.1097/00000539-200206000-00011

Wilcke JR, 1983, J Vet Pharmacol Ther, 6, 105, 10.1111/j.1365-2885.1983.tb00386.x

10.1046/j.1467-2995.2002.00084.x

Anis NA, 1983, Br J Pharmacol, 79, 565, 10.1111/j.1476-5381.1983.tb11031.x

Nagasaka H, 1993, Anesthesiology, 78, 722, 10.1097/00000542-199304000-00016

10.1016/0304-3959(82)90170-1

10.1016/S0304-3959(99)00044-5

10.1097/00000542-199612000-00017

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Thông tin xuất bản

American Journal of Veterinary Research

Tập 64 Số 9

1155-1160

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