Effects of long-term estrogen replacement therapy on the prevalence and area of periarticular tibial osteophytes in surgically postmenopausal cynomolgus monkeys

Sharma, 2001, The role of knee alignment in disease progression and functional decline in knee osteoarthritis, JAMA, 286, 188, 10.1001/jama.286.2.188 Felson, 2005, Osteophytes and progression of knee osteoarthritis, Rheumatology, 44, 100, 10.1093/rheumatology/keh411 Heffron, 1979, Osteophyte formation in the canine stifle joint following treatment for rupture of the cranial cruciate ligament, J Small Anim Pract, 20, 603, 10.1111/j.1748-5827.1979.tb06669.x Marshall, 1969, Periarticular osteophytes: initiation and formation in the knee of the dog, Clin Orthop Relat Res, 62, 37 Gilbertson, 1975, Development of periarticular osteophytes in experimentally induced osteoarthritis in the dog, Ann Rheum Dis, 34, 12, 10.1136/ard.34.1.12 Hayami, 2004, The role of subchondral bone remodeling in osteoarthritis, Arthritis Rheum, 50, 1193, 10.1002/art.20124 Hayami, 2006, Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis, Bone, 38, 234, 10.1016/j.bone.2005.08.007 Palmoski, 1982, Immobilization of the knee prevents osteoarthritis after anterior cruciate ligament transection, Arthritis Rheum, 25, 1201, 10.1002/art.1780251009 Moskowitz, 1999, Bone remodeling in osteoarthritis: subchondral and osteophytic responses, Osteoarthr Cartil, 7, 323, 10.1053/joca.1998.0181 van Osch, 1996, The relation between cartilage damage and osteophyte size in a murine model for osteoarthritis in the knee, Rheumatol Int, 16, 115, 10.1007/BF01409983 Hernborg, 1973, The relationship between osteophytes in the knee joint, osteoarthritis and aging, Acta Orthop Scand, 44, 69, 10.3109/17453677308988675 Klocke, 2005, Detection of synovial macrophages in the joint capsule of dogs with naturally occurring rupture of the cranial cruciate ligament, AJVR, 66, 493, 10.2460/ajvr.2005.66.493 Scharstuhl, 2002, Inhibition of endogenous TGF-β during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair, J Immunol, 169, 507, 10.4049/jimmunol.169.1.507 van Beuningen, 2000, Osteoarthritis like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections, Osteoarthr Cartil, 8, 25, 10.1053/joca.1999.0267 Bakker, 2001, Overexpression of active TGF-beta-1 in the murine knee joint: Evidence for synovial-layer-dependent chondro-osteophyte formation, Osteoarthr Cartil, 9, 128, 10.1053/joca.2000.0368 Blom, 2004, Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis, Osteoarthr Cartil, 12, 627, 10.1016/j.joca.2004.03.003 van Lent, 2004, Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation, Arthritis Rheum, 50, 103, 10.1002/art.11422 Cameron, 1994, Synovial fluid cytokine concentrations as possible prognostic indicators in the ALC-deficient knee, Knee Surg Sports Traumatol Arthrosc, 2, 38, 10.1007/BF01552652 Manicourt, 1999, Treatment with calcitonin suppresses the responses of bone, cartilage, and synovium in the early stages of canine experimental osteoarthritis and significantly reduces the severity of the cartilage lesions, Arthritis Rheum, 42, 1159, 10.1002/1529-0131(199906)42:6<1159::AID-ANR12>3.0.CO;2-Q Schlaak, 1996, Different cytokine profiles in the synovial fluid of patients with osteoarthritis, rheumatoid arthritis and seronegative spondylarthropathies, Clin Exp Rheumatol, 14, 155 Huch, 2003, PTHrP, PTHr, and FGFR3 are involved in the process of endochondral ossification in human osteophytes, Histochem Cell Biol, 119, 281, 10.1007/s00418-003-0519-2 Manninen, 1996, Overweight, gender, and knee osteoarthritis, Int J Obes Relat Metab Disord, 20, 595 Felson, 1988, Obesity and knee osteoarthritis. The Framingham study, Ann Intern Med, 109, 18, 10.7326/0003-4819-109-1-18 Felson, 1992, Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study, Ann Intern Med, 116, 535, 10.7326/0003-4819-116-7-535 Felson, 1997, Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham study, Arthritis Rheum, 40, 728, 10.1002/art.1780400420 Felson, 2000, Osteoarthritis: new insights, part 1: the disease and its risk factors, Ann Intern Med, 133, 635, 10.7326/0003-4819-133-8-200010170-00016 Dougados, 1992, Longitudinal radiologic evaluation of osteoarthritis of the knee, J Rheumatol, 19, 378 Schouten, 1992, A 12 year follow up study in the general population on prognostic factors of cartilage loss in osteoarthritis of the knee, Ann Rheum Dis, 51, 932, 10.1136/ard.51.8.932 Paatsama, 1972, Early changes in the knee joint due to instability induced by cutting of the anterior cruciate ligament: an experimental study in young dogs, Acta Radiol Suppl, 319, 169 Felson, 1995, The incidence and natural history of knee osteoarthritis in the elderly, Arthritis Rheum, 38, 1500, 10.1002/art.1780381017 Altman, 1995, Atlas of individual radiographic features in osteoarthritis, Osteoarthr Cartil, 3, 3 Nagaosa, 2000, Development of a logically devised line drawing atlas for grading of knee osteoarthritis, Ann Rheum Dis, 59, 587, 10.1136/ard.59.8.587 Nagaosa, 2002, Characterisation of size and direction of osteophyte in knee osteoarthritis: a radiographic study, Ann Rheum Dis, 61, 319, 10.1136/ard.61.4.319 Ono, 2000, Processes of osteophyte formation in guinea pigs with spontaneous osteoarthritis, Yonago Acta Med, 43, 131 Ham, 2002, Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys, Arthritis Rheum, 46, 1956, 10.1002/art.10406 Carlson, 1996, Osteoarthritis in cynomolgus macaques. III. Effects of age, gender, and subchondral bone thickness on severity of disease, J Bone Miner Res, 11, 1209, 10.1002/jbmr.5650110904 Clarkson, 2001, Inhibition of postmenopausal atherosclerosis progression: a comparison of the effects of conjugated equine estrogens and soy phytoestrogens, J Clin Endocrinol Metab, 86, 41 Bowen, 1970, Determination of age in monkeys (Macaca irus) on the basis of dental development, Lab Anim, 4, 113, 10.1258/002367770781036481 Ham, 2004, Effects of estrogen replacement therapy on bone turnover in subchondral bone and epiphyseal metaphyseal cancellous bone of ovariectomized cynomolgus monkeys, J Bone Miner Res, 19, 823, 10.1359/jbmr.040309