Effects of intravenous immunoglobulin on alpha synuclein aggregation and neurotoxicity

International Immunopharmacology - Tập 14 - Trang 550-557 - 2012
Lynnae M. Smith1, Andrea C. Klaver1, Mary P. Coffey2, Loan Dang3, David A. Loeffler1
1Department of Neurology Research, William Beaumont Hospital Research Institute, 3811 West Thirteen Mile Road, Royal Oak, MI 48073, USA
2Department of Biostatistics, William Beaumont Hospital Research Institute, 3811 West Thirteen Mile Road, Royal Oak, MI 48073, USA
3Eye Research Institute, Oakland University, 2200 Squirrel Road, Rochester, MI, 48309, USA

Tài liệu tham khảo

Polymeropoulos, 1997, Mutation in the alpha-synuclein gene identified in families with Parkinson's disease, Science, 276, 2045, 10.1126/science.276.5321.2045 Gasser, 2005, Genetics of Parkinson's disease, Curr Opin Neurol, 18, 363, 10.1097/01.wco.0000170951.08924.3d Eriksen, 2005, Gene dosage and pathogenesis of Parkinson's disease, Trends Mol Med, 11, 91, 10.1016/j.molmed.2005.01.001 Winkler, 2007, alpha-Synuclein and Parkinson disease susceptibility, Neurology, 69, 1745, 10.1212/01.wnl.0000275524.15125.f4 Chartier-Harlin, 2004, Alpha-synuclein locus duplication as a cause of familial Parkinson's disease, Lancet, 364, 1167, 10.1016/S0140-6736(04)17103-1 Chiba-Falek, 2006, Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients, Mov Disord, 21, 1703, 10.1002/mds.21007 Gründemann, 2011, UV-laser microdissection and mRNA expression analysis of individual neurons from postmortem Parkinson's disease brains, Methods Mol Biol, 755, 363, 10.1007/978-1-61779-163-5_30 Conway, 2000, Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy, Proc Natl Acad Sci U S A, 97, 571, 10.1073/pnas.97.2.571 Haass, 2007, Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide, Nat Rev Mol Cell Biol, 8, 101, 10.1038/nrm2101 Winner, 2011, In vivo demonstration that alpha-synuclein oligomers are toxic, Proc Natl Acad Sci U S A, 108, 4194, 10.1073/pnas.1100976108 Halliday, 2008, Human-based studies on alpha-synuclein deposition and relationship to Parkinson's disease symptoms, Exp Neurol, 209, 12, 10.1016/j.expneurol.2007.07.006 Sidhu, 2004, The role of alpha-synuclein in both neuroprotection and neurodegeneration, Ann N Y Acad Sci, 1035, 250, 10.1196/annals.1332.016 El-Agnaf, 2004, A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders, FASEB J, 18, 1315, 10.1096/fj.03-1346fje Amer, 2006, Inhibitors of alpha-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disorders, Exp Brain Res, 173, 223, 10.1007/s00221-006-0539-y Beyer, 2008, The therapeutical potential of alpha-synuclein antiaggregatory agents for dementia with Lewy bodies, Curr Med Chem, 15, 2748, 10.2174/092986708786242868 Caruana, 2011, Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds, FEBS Lett, 585, 1113, 10.1016/j.febslet.2011.03.046 Zhang, 2005, Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease, FASEB J, 19, 533, 10.1096/fj.04-2751com Couch, 2001, The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation, J Neuroinflammation, 8, 166, 10.1186/1742-2094-8-166 Klegeris, 2007, Complement activation by islet amyloid polypeptide (IAPP) and alpha-synuclein 112, Biochem Biophys Res Commun, 357, 1096, 10.1016/j.bbrc.2007.04.055 El-Agnaf, 2003, Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma, FASEB J, 17, 1945, 10.1096/fj.03-0098fje Lee, 2008, Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease, J Mol Neurosci, 34, 17, 10.1007/s12031-007-0012-9 El-Agnaf, 2006, Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease, FASEB J, 20, 419, 10.1096/fj.03-1449com Tokuda, 2010, Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease, Neurology, 75, 1766, 10.1212/WNL.0b013e3181fd613b Bruggink, 2010, Detection of elevated levels of {alpha}-synuclein oligomers in CSF from patients with Parkinson disease, Neurology, 77, 510, 10.1212/WNL.0b013e318219dd92 Mollenhauer, 2011, α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study, Lancet Neurol, 10, 230, 10.1016/S1474-4422(11)70014-X Aerts, 2012, CSF α-synuclein does not differentiate between parkinsonian disorders, Neurobiol Aging, 33, 430, 10.1016/j.neurobiolaging.2010.12.001 Parnetti, 2011, Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias, Mov Disord, 26, 1428, 10.1002/mds.23670 Li, 2008, Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation, Nat Med, 14, 501, 10.1038/nm1746 Desplats, 2009, Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein, Proc Natl Acad Sci U S A, 106, 13010, 10.1073/pnas.0903691106 Kordower, 2011, Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat, Neurobiol Dis, 43, 552, 10.1016/j.nbd.2011.05.001 Krammer, 2009, Prion-like propagation of cytosolic protein aggregates: insights from cell culture models, Prion, 3, 206, 10.4161/pri.3.4.10013 Masliah, 2005, Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease, Neuron, 46, 857, 10.1016/j.neuron.2005.05.010 Masliah, 2011, Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease, PLoS One, 6, e19338, 10.1371/journal.pone.0019338 Patrias, 2010, Specific antibodies to soluble alpha-synuclein conformations in intravenous immunoglobulin preparations, Clin Exp Immunol, 161, 527, 10.1111/j.1365-2249.2010.04214.x Scheinfeld Nimmerjahn, 2008, Anti-inflammatory actions of intravenous immunoglobulin, Annu Rev Immunol, 26, 513, 10.1146/annurev.immunol.26.021607.090232 Dodel, 2004, Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease, J Neurol Neurosurg Psychiatry, 75, 1472, 10.1136/jnnp.2003.033399 Relkin, 2009, 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease, Neurobiol Aging, 30, 1728, 10.1016/j.neurobiolaging.2007.12.021 Shankle, 2009, Longitudinal measure of IVIG treatment effect in patients with Alzheimer's and Lewy body disease, Alzheimers Dement, 5, 430, 10.1016/j.jalz.2009.04.968 Nanri, 2009, Intravenous immunoglobulin therapy for autoantibody-positive cerebellar ataxia, Intern Med, 48, 783, 10.2169/internalmedicine.48.1802 Zouali, 1986, Thymine and guanine base specificity of human myeloma proteins with anti-DNA activity, J Clin Invest, 78, 1173, 10.1172/JCI112699 Kuby, 1992, Immunology, 100 Diemel, 2005, Characterization of immunoglobulin G fragments in liquid intravenous immunoglobulin products, Transfusion, 45, 1601, 10.1111/j.1537-2995.2005.00549.x Klaver, 2010, Antibody levels to Aβ1–42 conformations differ between intravenous immunoglobulins, Int Immunopharmacol, 10, 115, 10.1016/j.intimp.2009.10.005 Biere, 2000, Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta- and gamma-synuclein and cannot cross-seed its homologs, J Biol Chem, 275, 34574, 10.1074/jbc.M005514200 Serpell, 2000, Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation, Proc Natl Acad Sci U S A, 97, 4897, 10.1073/pnas.97.9.4897 Uversky, 2002, Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins, J Biol Chem, 277, 11970, 10.1074/jbc.M109541200 Yonetani, 2009, Conversion of wild-type alpha-synuclein into mutant-type fibrils and its propagation in the presence of A30P mutant, J Biol Chem, 284, 7940, 10.1074/jbc.M807482200 LeVine, 1993, Thioflavine T, interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution, Protein Sci, 2, 404, 10.1002/pro.5560020312 Harper, 1997, Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins, Annu Rev Biochem, 66, 385, 10.1146/annurev.biochem.66.1.385 Giasson, 2001, A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly, J Biol Chem, 276, 2380, 10.1074/jbc.M008919200 Näsström, 2011, Antibodies against alpha-synuclein reduce oligomerization in living cells, PLoS One, 6, e27230, 10.1371/journal.pone.0027230 van Rooijen, 2010, Membrane interactions of oligomeric alpha-synuclein: potential role in Parkinson's disease, Curr Protein Pept Sci, 11, 334, 10.2174/138920310791330659 Reynolds, 2011, Mechanism of membrane interaction and disruption by α-synuclein, J Am Chem Soc, 133, 19366, 10.1021/ja2029848 Liu, 2011, A novel molecular mechanism for nitrated {alpha}-synuclein-induced cell death, J Mol Cell Biol, 3, 239, 10.1093/jmcb/mjr011 Vassilev, 1999, Inhibition of cell adhesion by antibodies to Arg-Gly-Asp (RGD) in normal immunoglobulin for therapeutic use (intravenous immunoglobulin, IVIg), Blood, 93, 3624, 10.1182/blood.V93.11.3624 Arredondo, 2005, Novel mechanisms of target cell death and survival and of therapeutic action of IVIg in Pemphigus, Am J Pathol, 167, 1531, 10.1016/S0002-9440(10)61239-4 Leytin, 2006, Intravenous immunoglobulin inhibits anti-glycoprotein IIb-induced platelet apoptosis in a murine model of immune thrombocytopenia, Br J Haematol, 133, 78 Winkler, 2012, Platelet apoptosis in paediatric immune thrombocytopenia is ameliorated by intravenous immunoglobulin, Br J Haematol, 156, 508, 10.1111/j.1365-2141.2011.08973.x Nakatani, 2002, Intravenous immunoglobulin (IVIG) preparations induce apoptosis in TNF-alpha-stimulated endothelial cells via a mitochondria-dependent pathway, Clin Exp Immunol, 127, 445, 10.1046/j.1365-2249.2002.01769.x Takeshita, 2005, Intravenous immunoglobulin preparations promote apoptosis in lipopolysaccharide-stimulated neutrophils via an oxygen-dependent pathway in vitro, APMIS, 113, 269, 10.1111/j.1600-0463.2005.apm_05.x Haussermann, 2001, Integrity of the blood–cerebrospinal fluid barrier in early Parkinson's disease, Neurosci Lett, 300, 182, 10.1016/S0304-3940(01)01574-9 DeMattos, 2001, Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease, Proc Natl Acad Sci USA, 98, 8850, 10.1073/pnas.151261398