Effects of intratracheally instilled laser printer-emitted engineered nanoparticles in a mouse model: A case study of toxicological implications from nanomaterials released during consumer use

Aldinucci, 2014, The inflammatory chemokine CCL5 and cancer progression, Mediat. Inflamm., 2014, 292376, 10.1155/2014/292376 Andrews, 2008, UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals, Nature, 454, 846, 10.1038/nature07181 Anjilvel, 1995, A multiple-path model of particle deposition in the rat lung, Fundam. Appl. Toxicol., 28, 41, 10.1006/faat.1995.1144 Appay, 2001, RANTES: a versatile and controversial chemokine, Trends Immunol., 22, 83, 10.1016/S1471-4906(00)01812-3 Bai, 2010, Pulmonary responses to printer toner particles in mice after intratracheal instillation, Toxicol. Lett., 199, 288, 10.1016/j.toxlet.2010.09.011 Banner, 1998, Leukemia inhibitory factor is an anti-inflammatory and analgesic cytokine, J. Neurosci., 18, 5456, 10.1523/JNEUROSCI.18-14-05456.1998 Beck, 1982, An in vivo hamster bioassay to assess the toxicity of particulates for the lungs, Toxicol. Appl. Pharmacol., 66, 9, 10.1016/0041-008X(82)90057-6 Boissel, 2004, The neuronal nitric oxide synthase is upregulated in mouse skin repair and in response to epidermal growth factor in human HaCaT keratinocytes, J. Invest. Dermatol., 123, 132, 10.1111/j.0022-202X.2004.22731.x Bourc'his, 2004, Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L, Nature, 431, 96, 10.1038/nature02886 Brain, 1976, Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation, Environ. Res., 11, 13, 10.1016/0013-9351(76)90107-9 Chakrabarti, 2012, Neuronal nitric oxide synthase regulates endothelial inflammation, J. Leukoc. Biol., 91, 947, 10.1189/jlb.1011513 Chang, 2013, Physicochemical and toxicological characteristics of welding fume derived particles generated from real time welding processes, Environ. Sci. Process. Impacts, 15, 214, 10.1039/C2EM30505D Cohen, 2012, Interactions of engineered nanomaterials in physiological media and implications for in vitro dosimetry, Nanotoxicology, 7, 417, 10.3109/17435390.2012.666576 Demokritou, 2004, A compact multistage (cascade) impactor for the characterization of atmospheric aerosols, J. Aerosol Sci., 35, 281, 10.1016/j.jaerosci.2003.09.003 Driscoll, 2000, Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations, Toxicol. Sci., 55, 24, 10.1093/toxsci/55.1.24 Dudzinski, 2006, The regulation and pharmacology of endothelial nitric oxide synthase, Annu. Rev. Pharmacol. Toxicol., 46, 235, 10.1146/annurev.pharmtox.44.101802.121844 Echtay, 2002, Superoxide activates mitochondrial uncoupling proteins, Nature, 415, 96, 10.1038/415096a Foronjy, 2014, Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection, BMC Immunol., 15, 41, 10.1186/s12865-014-0041-4 Forstermann, 1998, Expressional control of the ‘constitutive’ isoforms of nitric oxide synthase (NOS I and NOS III), FASEB J., 12, 773, 10.1096/fasebj.12.10.773 Gong, 2010, SiO(2) nanoparticles induce global genomic hypomethylation in HaCaT cells, Biochem. Biophys. Res. Commun., 397, 397, 10.1016/j.bbrc.2010.05.076 Goodman, 2010, What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments?, Toxicol. Sci., 116, 375, 10.1093/toxsci/kfq133 Grasselli, 2014, Thyromimetic actions of tetrabromobisphenol A (TBBPA) in steatotic FaO rat hepatoma cells, Chemosphere, 112, 511, 10.1016/j.chemosphere.2014.03.114 Hancock, 2008, Nitric oxide synthase genes and their interactions with environmental factors in Parkinson's disease, Neurogenetics, 9, 249, 10.1007/s10048-008-0137-1 He, 2007, Particle emission characteristics of office printers, Environ. Sci. Technol., 41, 6039, 10.1021/es063049z Iwase, 2000, Induction of endothelial nitric-oxide synthase in rat brain astrocytes by systemic lipopolysaccharide treatment, J. Biol. Chem., 275, 11929, 10.1074/jbc.275.16.11929 Jastroch, 2010, Mitochondrial proton and electron leaks, Essays Biochem., 47, 53, 10.1042/bse0470053 Jones, 2012, Functions of DNA methylation: islands, start sites, gene bodies and beyond, Nat. Rev. Genet., 13, 484, 10.1038/nrg3230 Khatri, 2013, Toxicological effects of p M0.25-2.0 particles collected from a photocopy center in three human cell lines, Inhal. Toxicol., 25, 621, 10.3109/08958378.2013.824525 Koturbash, 2011, Role of epigenetic events in chemical carcinogenesis — a justification for incorporating epigenetic evaluations in cancer risk assessment, Toxicol. Mech. Methods, 21, 289, 10.3109/15376516.2011.557881 Krauss, 2005, The mitochondrial uncoupling-protein homologues, Nat. Rev. Mol. Cell Biol., 6, 248, 10.1038/nrm1592 Levinsson, 2014, Nitric oxide synthase (NOS) single nucleotide polymorphisms are associated with coronary heart disease and hypertension in the INTERGENE study, Nitric Oxide, 39, 1, 10.1016/j.niox.2014.03.164 Lu, 2015, Short-term exposure to engineered nanomaterials affects cellular epigenome, Nanotoxicology, 1, 10.3109/17435390.2015.1025115 Lu, 2015, In vivo epigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles, Nanotoxicology, 1, 10.3109/17435390.2015.1025115 Martinelli, 2009, ICAM-1-mediated endothelial nitric oxide synthase activation via calcium and AMP-activated protein kinase is required for transendothelial lymphocyte migration, Mol. Biol. Cell, 20, 995, 10.1091/mbc.e08-06-0636 Miousse, 2015, The fine LINE; methylation drawing the cancer landscape, Biomed. Res. Int., 10.1155/2015/131547 Miousse, 2014, Epigenetic alterations induced by ambient particulate matter in mouse macrophages, Environ. Mol. Mutagen., 55, 428, 10.1002/em.21855 Miousse, 2014, Exposure to low-dose (56)Fe-ion radiation induces long-term epigenetic alterations in mouse bone marrow hematopoietic progenitor and stem cells, Radiat. Res., 182, 92, 10.1667/RR13580.1 Morawska, 2009, An investigation into the characteristics and formation mechanisms of particles originating from the operation of laser printers, Environ. Sci. Technol., 43, 1015, 10.1021/es802193n Morimoto, 2013, Pulmonary toxicity of printer toner following inhalation and intratracheal instillation, Inhal. Toxicol., 25, 679, 10.3109/08958378.2013.835010 Muhle, 1991, Pulmonary response to toner upon chronic inhalation exposure in rats, Fundam. Appl. Toxicol., 17, 280, 10.1016/0272-0590(91)90219-T Osier, 1997, Intratracheal inhalation vs intratracheal instillation: differences in particle effects, Fundam. Appl. Toxicol., 40, 220, 10.1006/faat.1997.2390 Pal, 2015, Linking exposures of particles released from nano-enabled products to toxicology: an integrated methodology for particle sampling, extraction, dispersion, and dosing, Toxicol. Sci., 146, 321, 10.1093/toxsci/kfv095 Patti, 2010, The role of mitochondria in the pathogenesis of type 2 diabetes, Endocr. Rev., 31, 364, 10.1210/er.2009-0027 Pirela, 2013, Effects of copy center particles on the lungs: a toxicological characterization using a Balb/c mouse model, Inhal. Toxicol., 25, 498, 10.3109/08958378.2013.806614 Pirela, 2014, Development and characterization of an exposure platform suitable for physico-chemical, morphological and toxicological characterization of printer-emitted particles (PEPs), Inhal. Toxicol., 26, 400, 10.3109/08958378.2014.908987 Pirela, 2014, Consumer exposures to laser printer-emitted engineered nanoparticles: a case study of life-cycle implications from nano-enabled products, Nanotoxicology, 9, 760, 10.3109/17435390.2014.976602 Pirela, 2015, Laser printer-emitted engineered nanoparticles lead to cytotoxicity, inflammation and changes in dna methylation in human cells, Environ. Health Perspect. Quinton, 2008, Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia, Am. J. Respir. Cell Mol. Biol., 38, 699, 10.1165/rcmb.2007-0365OC Quinton, 2012, Leukemia inhibitory factor signaling is required for lung protection during pneumonia, J. Immunol., 188, 6300, 10.4049/jimmunol.1200256 Sarkar, 2014, Low dose of arsenic trioxide triggers oxidative stress in zebrafish brain: expression of antioxidant genes, Ecotoxicol. Environ. Saf., 107, 1, 10.1016/j.ecoenv.2014.05.012 Sellers, 2013, Nitric oxide and TNFalpha are critical regulators of reversible lymph node vascular remodeling and adaptive immune response, PLoS One, 8, 10.1371/journal.pone.0060741 Sisler, 2014, Small airway epithelial cells exposure to printer-emitted engineered nanoparticles induces cellular effects on human microvascular endothelial cells in an alveolar-capillary co-culture model, Nanotoxicology, 1 Song, 2012, Low-level phenolic estrogen pollutants impair islet morphology and beta-cell function in isolated rat islets, J. Endocrinol., 215, 303, 10.1530/JOE-12-0219 Steer, 2013, Early induction of uncoupling protein-2 in pulmonary macrophages in hyperoxia-associated lung injury, Inhal. Toxicol., 25, 544, 10.3109/08958378.2013.810679 Terasaki, 2013, In vitro screening for compounds that enhance human L1 mobilization, PLoS One, 8, 10.1371/journal.pone.0074629 Wahl, 2003, Nitric oxide in experimental joint inflammation. Benefit or detriment?, Cells Tissues Organs, 174, 26, 10.1159/000070572 Wang, 2012, Ozone-initiated particle formation, particle aging, and precursors in a laser printer, Environ. Sci. Technol., 46, 704, 10.1021/es203066k Zhao, 2013, Acute ZnO nanoparticles exposure induces developmental toxicity, oxidative stress and DNA damage in embryo-larval zebrafish, Aquat. Toxicol., 136–137, 49, 10.1016/j.aquatox.2013.03.019