Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Ảnh hưởng của khoảng thời gian giữa độ tuổi mang thai đầu tiên và độ tuổi chẩn đoán đến khả năng sống sót sau ung thư vú theo tình trạng mãn kinh: nghiên cứu dựa trên đăng ký tại Hàn Quốc
Tóm tắt
Ảnh hưởng của số lần sinh và khoảng thời gian giữa tuổi mang thai đầu tiên (AFP) và độ tuổi chẩn đoán đến khả năng sống sót sau ung thư vú chưa được xác định giống như ảnh hưởng của chúng đến nguy cơ ung thư vú. Chúng tôi nhằm điều tra mối liên hệ giữa khoảng thời gian hoặc số lần sinh với tiên lượng ở phụ nữ tiền mãn kinh và hậu mãn kinh tại Hàn Quốc. Chúng tôi đã tiến hành một nghiên cứu hồi cứu trên 29.167 phụ nữ mắc ung thư vú thông qua Đăng ký Ung thư Vú Hàn Quốc từ năm 1993-2009. Thông tin về các yếu tố sinh sản, bao gồm cho con bú, AFP và số lần sinh đã được thu thập từ bảng hỏi định kỳ. Phân tích hồi quy logistic điều kiện được sử dụng để ước lượng mối liên hệ giữa tình trạng mãn kinh và tỷ lệ tử vong tổng thể (OM) cũng như tỷ lệ tử vong đặc hiệu do ung thư vú (BCSM), điều chỉnh theo điều trị và giai đoạn bệnh. Số lần sinh cao (≥5) làm tăng tỷ lệ rủi ro (HR) của BCSM (HR = 1.33, khoảng tin cậy (CI) 95%: 0.83–2.11, p < 0.001) và OM (HR = 1.20, 95% CI: 0.85–1.68.73, p < 0.001) ở phụ nữ tiền mãn kinh và hậu mãn kinh (BCSM, HR: 1.62, 95% CI: 0.93–2.82, p < 0.001; OM, HR = 1.58, 95% CI: 1.14–2.21, p <0.001). Khoảng thời gian lâu hơn giữa độ tuổi chẩn đoán ung thư vú và AFP làm giảm HR của BCSM (HR = 0.97, 95% CI: 0.96–0.98, p = 0.001) và OM (HR = 0.98, 95% CI: 0.97–0.98, p < 0.001) ở phụ nữ tiền mãn kinh, nhưng lại có tác động tiêu cực đến HR của OM (HR = 1.03, 95% CI: 1.02–1.03, p < 0.001) ở phụ nữ hậu mãn kinh. Số lần sinh cao (≥5) liên quan đến tiên lượng ung thư vú kém ở cả phụ nữ tiền mãn kinh và hậu mãn kinh. Các khoảng thời gian giữa các sự kiện sinh sản có tác động khác nhau đến các kết quả ung thư vú tùy thuộc vào tình trạng mãn kinh.
Từ khóa
Tài liệu tham khảo
Chie WC, Hsieh CC, Newcomb PA, Longnecker MP, Mittendorf R, Greenberg ER: Age at any full-term pregnancy and breast cancer risk. Am J Epidemiol. 2000, 151: 715-722. 10.1093/oxfordjournals.aje.a010266.
Largent JA, Ziogas A, Anton-Culver H: Effect of reproductive factors on stage, grade and hormone receptor status in early-onset breast cancer. Breast Cancer Res. 2005, 7: R541-R554. 10.1186/bcr1198.
Ma H, Bernstein L, Pike MC, Ursin G: Reproductive factors and breast cancer risk according to joint estrogen and progesterone receptor status: a meta-analysis of epidemiological studies. Breast Cancer Res. 2006, 8: R43-10.1186/bcr1525.
Xing P, Li J, Jin F: A case–control study of reproductive factors associated with subtypes of breast cancer in Northeast China. Med Oncol. 2010, 27: 926-931. 10.1007/s12032-009-9308-7.
Suzuki R, Rylander-Rudqvist T, Ye W, Saji S, Wolk A: Body weight and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status among Swedish women: a prospective cohort study. Int J Cancer. 2006, 119: 1683-1689. 10.1002/ijc.22034.
Iwasaki M, Otani T, Inoue M, Sasazuki S, Tsugane S: Japan Public Health Center-Based Prospective study group. Body size and risk for breast cancer in relation to estrogen and progesterone receptor status in Japan. Ann Epidemiol. 2007, 17: 304-312. 10.1016/j.annepidem.2006.09.003.
Rennert G, Bisland-Naggan S, Barnett-Griness O, Bar-Joseph N, Zhang S, Rennert HS, SA : Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations. N Engl J Med. 2007, 357: 115-123. 10.1056/NEJMoa070608.
van der Hage JA, Mieog JS, van de Velde CJ, Putter H, Bartelink H, van de Vijver MJ: Impact of established prognostic factors and molecular subtype in very young breast cancer patients: pooled analysis of four EORTC randomized controlled trials. Breast Cancer Res. 2011, 13: R68-10.1186/bcr2908.
Blows FM, Driver KE, Schmidt MK, Broeks A, van Leeuwen FE, Wesseling J: Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies. PLoS Med. 2010, 7: e1000279-10.1371/journal.pmed.1000279. doi:10.1371/journal.pmed.1000279
Nagatsuma AK, Shimizu C, Takahashi F, Tsuda H, Saji S, Hojo T: Impact of recent parity on histological tumor features and breast cancer outcome in premenopausal Japanese women. Breast Cancer Res Treat. 2013, 138: 941-950. 10.1007/s10549-013-2507-0.
Alsaker MD, Opdahl S, Asvold BO, Romundstad PR, Vatten LJ: The association of reproductive factors and breastfeeding with long term survival from breast cancer. Breast Cancer Res Treat. 2011, 130: 175-182. 10.1007/s10549-011-1566-3.
Ahn SH, Son BH, Kim SW, Kim SI, Jeong J, Ko SS: Poor outcome of hormone receptor-positive breast cancer at very young age is due to tamoxifen resistance: nationwide survival data in Korea—a report from the Korean Breast Cancer Society. J Clin Oncol. 2007, 25: 2360-2368. 10.1200/JCO.2006.10.3754.
Russo J, Moral R, Balogh GA, Mailo D, Russo IH: The protective role of pregnancy in breast cancer. Breast Cancer Res. 2005, 7: 131-142. 10.1186/bcr1029.
Russo J, Balogh GA, Russo IH: Full-term pregnancy induces a specific genomic signature in the human breast. Cancer Epidemiol Biomarkers Prev. 2008, 17: 51-66. 10.1158/1055-9965.EPI-07-0678.
Loman N, Johannsson O, Kristoffersson U, Olsson H, Borg A: Family history of breast and ovarian cancers and BRCA1 and BRCA2 mutations in a population- based series of early-onset breast cancer. J Natl Cancer Inst. 2001, 93: 1215-1223. 10.1093/jnci/93.16.1215.
Anders CK, Hsu DS, Broadwater G, Acharya CR, Foekens JA, Zhang Y: Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancer with shared patterns of gene expression. J Clin Oncol. 2008, 26: 3324-3330. 10.1200/JCO.2007.14.2471.
Bladström A, Anderson H, Olsson H: Worse survival in breast cancer among women with recent childbirth: results from a Swedish population- based register study. Clin Breast Cancer. 2003, 4: 280-285. 10.3816/CBC.2003.n.033.
Ahn SH, Yoo KY, Korean Breast Cancer Society: Chronological changes of clinical characteristics in 31,115 new breast cancer patients among Korean during 1996–2004. Breast Cancer Res Treat. 2006, 99: 209-214. 10.1007/s10549-006-9188-x.
Lee JS, Oh MK, Korean Breast Cancer Society: Reproductive factors and subtypes of breast cancer defined by Estrogen receptor, Progesterone receptor, and Human Epidermal Growth Factor Receptor 2: A Register-Based Study from Korea. Clin Breast Cancer. 2014, ᅟ: ᅟ-doi:10.1016/j.clbc.2014.05.003
American Joint Committee on Cancer: Manual for Staging of Cancer. 1997, Philadelphia: Lippincott-Raven Publishers
Anderson WF, Jatoi I, Devesa SS: Distinct breast cancer incidence and prognostic patterns in the NCI’s SEER program: suggesting a possible link between etiology and outcome. Breast Cancer Res Treat. 2005, 90: 127-137. 10.1007/s10549-004-3777-3.
Barnett GC, Shah M, Redman K, Easton DF, Ponder BA, Pharoah PD: Risk factors for the incidence of breast cancer: do they effect survival from the disease?. J Clin Oncol. 2008, 26: 3310-3316. 10.1200/JCO.2006.10.3168.
Rosenberg L, Thalib L, Adami HO, Hall P: Childbirth and breast cancer prognosis. Int J Cancer. 2004, 111: 772-776. 10.1002/ijc.20323.
Kroman N, Wohlfahrt J, Andersen KW, Mouridsen HT, Westergaard T, Melbye M: Parity, age at first childbirth and the prognosis of primary breast cancer. Br J Cancer. 1998, 78: 1529-1533. 10.1038/bjc.1998.718.
Albrektsen G, Heuch I, Thoresen SØ: Histological type and grade of breast cancer tumors by parity, age at birth and time since birth: a register-based study in Norway. BMC Cancer. 2010, 10: 226-10.1186/1471-2407-10-226.
Wohlfahrt J, Andersen PK, Mouridsen HT, Adami HO, Melbye M: Reproductive history and stage of breast cancer. Am J Epidemiol. 1999, 150: 1325-1330. 10.1093/oxfordjournals.aje.a009964.
Butt S, Borgquist S, Anagnostaki L, Landberg G, Manjer J: Parity and age first childbirth in relation to the risk of different breast cancer subgroups. Int J Cancer. 2009, 125: 1926-1934. 10.1002/ijc.24494.
Schouten LJ, Hupperets PSGJ, Jager JJ, Volovics L, Wils JA, Verbeek ALM: Prognostic significance of etiological risk factors in early breast cancer. Breast Cancer Res Treat. 1997, 43: 217-223. 10.1023/A:1005790531122.
Phipps AI, Chlebowski RT, Prentice R, McTiernan A, Wactawski-Wende J, Kuller LH: Reproductive history and oral contraceptive use in relation to risk of triple negative breast cancer. J Natl Cancer Inst. 2011, 103: 470-477. 10.1093/jnci/djr030.
Alsaker MD, Opdahl S, Romundstad PR, Vatten LJ: Association of time since last birth, age at first birth and parity with breast cancer survival among parous women: a register-based study from Norway. Int J Cancer. 2013, 132: 174-181. 10.1002/ijc.27593.
Bernstein L: Epidemiology of endocrine-related risk factors for breast cancer. J Mammary Gland Biol Neoplasia. 2002, 7: 3-15. 10.1023/A:1015714305420.
Kelsey JL, Gammon MD, John EM: Reproductive factors and breast cancer. Epidemiol Rev. 1993, 15: 36-47.
Kwan ML, Kushi LH, Weltzien E, Maring B, Kutner SE, Fulton RS: Epidemiology of breast cancer subtypes in two prospective cohort studies of breast cancer survivors. Breast Cancer Res. 2009, 11: R31-10.1186/bcr2261.
Butt S, Borgquist S, Garne JP: Parity in relation to survival following breast cancer. Eur J Surg Oncol. 2009, 35: 702-708. 10.1016/j.ejso.2008.03.017.
Asztalos S, Gann PH, Hayes MK, Nonn L, Beam CA, Dai Y: Gene expression patterns in the human breast after pregnancy. Cancer Prev Res. 2010, 3: 301-311. 10.1158/1940-6207.CAPR-09-0069.
Huang W, Newman B, Millikan RC, Schell MJ, Hulka BS, Moorman PG: Hormone-related factors and risk of breast cancer in relation to estrogen receptor and progesterone receptor status. Am J Epidemiol. 2000, 151: 703-714. 10.1093/oxfordjournals.aje.a010265.
Phillips KA, Milne RL, West DW, Goodwin PJ, Giles GG, Chang ET: Prediagnostic reproductive factors and all-cause mortality for women with breast cancer in the breast cancer family registry. Cancer Epidemiol Biomarkers Prev. 2009, 18: 1792-1797. 10.1158/1055-9965.EPI-08-1014.
Kroman N, Wohlfahrt J, Andersen KW, Mouridsen HT, Westergaard T, Melbye M: Time since childbirth and prognosis in primary breast cancer: population based study. BMJ. 1997, 315: 851-855. 10.1136/bmj.315.7112.851.
Albrektsen G, Heuch I, Thoresen Kvåle GS: Clinical stage of breast cancer by parity, age at birth, and time since birth: a prospective effect of pregnancy hormones?. Cancer Epidemiol Biomarkers Prev. 2006, 15: 65-69. 10.1158/1055-9965.EPI-05-0634.
Daling JR, Malone KE, Doody DR, Anderson BO, Porter PL: The relation of reproductive factors to mortality from breast cancer. Cancer Epidemiol Biomarkers Prev. 2002, 1: 235-241.
Dodds L, Fell DB, Joseph KS, Dewar R, Scott H, Platt R: Relationship of time since childbirth and other pregnancy factors to premenopausal breast cancer prognosis. Obstet Gynecol. 2008, 111: 1167-1173. 10.1097/AOG.0b013e31816fd778.
Grubbs CJ, Hill DL, McDonough KC, Peckham JC: N-nitroso-N-methylurea-induced mammary carcinogenesis: effect of pregnancy on preneoplastic cells. J Natl Cancer Inst. 1983, 7: 625-628.
Liu B, Ordonez-Ercan D, Fan Z, Huang X, Edgerton SM, Yang X: Estrogenic promotion of ErbB2 tyrosine kinase activity in mammary tumor cells requires activation of ErbB3 signaling. Mol Cancer Res. 2009, 7: 1882-1892.
Balogh GA, Russo IH, Spittle C, Heulings R, Russo J: Immune-surveillance and programmed cell death-related genes are significantly overexpressed in the normal breast epithelium of postmenopausal parous women. Int J Oncol. 2007, 31: 303-312.
The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6874/14/113/prepub