Effects of interleukin-1? and tumor necrosis factor-? on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro

Beresford, J. N., J. A. Gallagher, M. Gowen, M. Couch, J. Poser, D. D. Wood, andR. G. G. Russell. 1984. The effects of monocyte-conditioned medium and interleukin 1 on the synthesis of collagenous and noncollagenous proteins by mouse bone and human bone cells in vitro.Biochim. Biophys. Acta 804:58?65.

Bertolini, D. R., G. E. Nedwin, T. S. Bringman, D. D. Smith, andG. R. Mundy. 1986. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumor necrosis factors.Nature 319:516?518.

Gowen, M., D. D. Wood, E. J. Ibrie, M. K. B. McGuire, andR. G. G. Russell. 1983. An interleukin 1-like factor stimulates bone resorption in vitro.Nature 306:378.

Goldring, S. R., M. S. Flannery, T. Harris, P. L. Killian, K. L. Kaffka, andM. B. Goldring. 1988. Biologic effects of IL-1 on human osteoblast-like cells are mediated by specific receptors.J. Bone Mineral Res. 4:S257.

Rodan, S. B., G. Wesolowski, C. Jayne, G. A. Limjuco, J. A. Schmidt, andG. A. Rodan. 1990. IL-1 binds to high affinity receptors on human osteosarcoma cells and potentiates prostaglandin E2 stimulation of cAMP production.J. Immunol. 145:1231?1237.

Dinarello, C. A., andN. Savage. 1989. Interleukin-1 and its receptor.Crit. Rev. Immunol. 9:1?20.

Rosenblum, M. G., andN. J. Donato. 1989. Tumor necrosis factor-alpha: A multifaceted peptide hormone.Crit. Rev. Immunol. 9:21?44.

Marks, S. C., andS. N. Popoff. 1988. Bone cell biology: The regulation of development, structure, and function in the skeleton.Am. J. Anal. 183:1?44.

Canalis, E. 1987. Effects of tumor necrosis factor on bone formation in vitro.Endocrinology 121:1596?1604.

Ikeda, E., M. Kusaka, Y. Hakeda, K. Yokota, M. Kumegawa, andS. Yamamoto. 1988. Effect of interleukin 1 beta on osteoblastic clone MC3T3-E1 cells.Calcif. Tissue Int. 43:162?166.

Evans, D. B., R. A. D. Bunning, andR. G. G. Russell. 1990. The effects of recombinant human interleukin-1/? on cellular proliferation and the production of prostaglandin E2, plasminogen activator, osteocalcin and alkaline phophatase by osteoblast-like cells derived from human bone.Biochem. Biophys. Res. Commun. 166:206?216.

Evans, D. B., M. Thavarjah, andJ. A. Kamis. 1990. Involvement of prostaglandin E2 in the inhibition of osteocalcin synthesis by human osteoblast-like cells in response to cytokines and systemic hormones.Biochem. Biophys. Res. Commun. 167:194?202.

Nanes, M. S., W. M. McKoy, andS. J. Marx. 1989. Inhibitory effects of tumor necrosis factor-alpha and interferon-gamma on deoxyribonucleic acid and collagen synthesis by rat osteosarcoma cells (ROS 17/2.8).Endocrinology 124:339?345.

Stashenko, P., M. S. Obernesser, andF. E. Dewhirst. 1989. Effects of immune cytokines on bone.Immunol. Invest. 18:239?249.

Ohmori, Y., S. Hanazawa, S. Amano, K. Hirose, M. Kumegawa, andS. Kitano. 1989. Effects of recombinant interleukin 1? and interleukin 1? on cell growth and alkaline phosphatase of the mouse osteoblastic cell line MC3T3-E1.Biochem. Biophys. Res. Commun. 970:22?30.

Stashenko, P., F. E. Dewhirst, W. J. Peros, R. L. Kent, andJ. M. Ago. 1987. Synergistic interactions between interleukin-1, tumor necrosis factor, and lymphotoxin in bone resorption.J. Immunol. 138:1464?3468.

Thompson, B. M., J. Saklatvala, T. J. Chambers. 1986. Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteocalasts.J. Exp. Med. 146:104?112.

Thompson, B. M., G. R. Mundy, andT. J. Chambers. 1987. Tumor necrosis factors alpha and beta induce osteoblasts to stimulate osteocalstic bone resorption.J. Immunol. 138:775?779.

Rodan Gam Martin, T. J. 1981. Role of osteoblast in hormonal control of bone resorption ?a hypothesis.Calcif. Tissue Int. 33:349?351.

Hauschka, P. V., J. B. Lian, D. E. C. Cole, andC. M. Gundburg. 1989. Osteocalcin and matrix Gla protein: Vitamin K-dependent proteins of bone.Physiol. Rev. 69:990?1047.

Hauschka, P. V., andF. H. Wians, Jr. 1989. Osteocalcin-hydroxyapatite interaction in the extracellular organic matrix of bone.Anat. Rec. 69:990?1047.

Malone, J. D. S., S. L. Teitelbaum, G. L. Griffin, R. M. Senior, andA. J. Kahn. 1982. Recruitment of osteocalcast precursors by purified bone matrix constituants.J. Cell Biol. 92:227?235.

Glowacki, J., andJ. B. Lian. 1987. Impaired recruitment and differentiation of osteocalast progenitors by osteocalcin deplete bone implants.Cell Differ. 21:247?254.

Webber, D., P. Osdoby, P. Hauschka, andM. Krukowski. 1990. Correlation of an osteoclast antigen and raffled border on giant cells formed in response to resorbable substrates.J. Bone Mineral Res. 5:401?410.

Hauschka, P. V., andM. L. Reid. 1987. Timed appearance of a calcium-binding protein containing gamma-carboxyglutamic acid in developing chicken bone.Dev. Biol. 122:49?60.

Gerstenfeld, L. C., S. D. Chipman, J. Golwacki, andJ. B. Lian. 1987. Expression of differentiated function by mineralizing cultures of chicken osteoblasts.Dev. Biol. 122:49?60.

Hauschka, P. V., T. L. Chen, andA. E. Mavrakos. 1988. Polypeptide growth factors in bone matrix.In Cell and Molecular Biology of Vertebrate Hard Tissues. CIBA Foundation Symposium 136, Wiley, New York. 103?125.

Gowen, M., D. E. Huges, andR. G. G. Russell. 1988. Tumor necrosis factor (TNF): An autocrine and paracrine regulator of bone metabolism.J. Bone Mineral Res. 42:S122.

Gowen, M., B. R. M. McDonald, R. G. G. Russell. 1988. Actions of recombinant human gamma interferon and TNF-alpha on the proliferation and osteoblast characteristics of human trabecular bone cells in vitro.Arthritis Rheum. 31:1500?1507.

Gowen, M., K. Chapman, A. Littlewood, D. Hughes, D. Evans, andR. G. G. Russell. 1990. Production of TNF by human osteoblasts is modulated by other cytokines, but not by osteopetrotic hormones.Endocrinology 126:1250?1255.

Evans, D. B., R. A. D. Bunning, J. Vandamme, andR. G. G. Russell. 1989. Natural human IL-1? exhibits regulatory actions on human bone-derived cells in vitro.Biochem. Biophys. Res. Commun. 159:1242?1248.

Aronow, M. A., L. C. Gerstenfeld, T. A. Owen, M. S. Tassinari, G. S. Stein, andJ. B. Lian. 1990. Factors that promote progressive development of the osteoblast phenotype in cultured fetal rat calvaria cells.J. Cell. Physiol. 143:213?221.

Kawano, M., I. Yamamoto, K. Iwato, H. Tanaka Hm Asaoku, O. Tanabe, H. Ishikawa, M. Nobuyoshi, Y. Ohmoto, Y. Hirai, andA. Kuramoto. 1989. Interleukin-1 beta rather than lymphotoxin as the major bone resorbing activity in human multiple myeloma.Blood 73:1646?1649.

Cohn, D. V., andG. Wong. 1975. Target cells in bone for parathyroid hormone and calcitonin are different. Enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces.Proc. Natl. Acad. Sci. U.S.A. 72:3167?3171.

Gundburg, C. M., P. V. Hauschka, J. B. Lian, andP. M. Gallop. 1984. Osteocalcin: Isolation, characterization, and detection.Methods Enzymol. 107:516?544.

Vytasek, R. 1982. A sensitive fluorometric assay for the determination of DNA.Anal. Biochem. 48:242?248.

Bellows, C. G., J. E. Aubin, J. N. M. Heersche, andM. E. Antosz. 1986. Mineralized nodules formed in vitro from enzymatically released rat calvarial cell populations.Calcif. Tissue Int. 38:143?154.

Reddi, A. H., andC. B. Huggins. 1972. Biochemical sequences in the transformation of normal fibroblasts in adolescent rats.Proc. Natl. Acad. Sci. U.S.A. 69:1601?1604.

Sambrook, J., E. F. Fritsch, andT. Maniatis. 1989. Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

Thomas, P. S. 1980. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.Proc. Natl. Acad. Sci. U.S.A. 77:5201.

Celeste, A. J., V. Rosen, L. J. Buecker, R. Kriz, E. A. Wang, andJ. M. Wozney. 1986. Isolation of the human gene for bone Gla protein utilizing mouse and rat cDNA clones.EMBO J. 5:1855?1859.

Feinberg, A. P., andB. Vogelstein. 1983. A technique for radiolabling DNA restriction endonuclease fragments to a high specific activity.Anal. Biochem. 132:6?13.

Dewhirst, F. E., P. P. Stashenko, J. E. Mole, andT. Tsurumachi. 1985. Purification and partial sequence of human osteocalcast activating factor: Identity with interleukin-1 beta.J. Immunol. 135:2562?2586.

Nanes, M. S., J. M. Rubin, G. Titus, G. Hendy, andB. D. Catherwood. 1990. Tumor necrosis factor-alpha inhibits bone Gla protein synthesis by pre- and post-translational elements.J. Bone Mineral Res. 5:S153.

Schule, R., K. Unesono, D. J. Mangelsdorf, J. Bolafo, J. W. Pike, andR. M. Evans. 1990. Jun-fos and receptors of vitamin A and D recognize a common response element in the human osteocalcin gene.Cell. 61:497?504.

Hauschka, P. V. 1990. Growth factor effects in bone.In Bone: A Treatise, The Osteoblast and the Osteocyte, Vol. 1. B. K. Hall, editor. Telford Press, Caldwell, New Jersey. 103?170.

Stein, G. S., J. B. Lian, andT. A. Owen. 1990. Relationship of growth to the regulation of tissue-specific gene expression during osteoblast differentiation.FASEB J. 4:3111?3123.

Lian, J. B., C. Stewart, E. Pucacz, M. Mackowiak, V. Shalhoub, D. Collart, G. Zambetti, andG. Siein. 1989. Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression.Proc. Natl. Acad. Sci. U.S.A. 86:1143?1147.

Muegge, K., T. M. Williams, J. Kant, M. Karin, R. Chiu, A. Schmidt, U. Siebenlist, H. A. Young, andS. K. Durum. 1989. Interleukin-1 costimulatory activity in the interleukin-2 promotor via AP-1.Science 246:249?251.

Brenner, D. A. A., M. O'Hara, P. Angel, M. Chojkier, andM. Karin. 1989. Prolonged action of jun and collagerase genes by TNF-?.Nature 337:661?664.

Taichman, R. S. 1990. Polyctokine modulation of bone metabolism: The effects of IFN-gamma on IL-1 beta and TNF-alpha inhibition of osteocalcin synthesis. Boston, Massachusetts. Harvard School of Dental Medicine. Dissertation. 176 pp.

Stashenko, P., F. E. Dewhirst, M. L. Rooney, L. A. Desjardins, andJ. D. Heeley. 1987. Interleukin-1-beta is a potent inhibitor of bone formation.J. Bone Mineral Res. 2:559?565.

Hughes, D. E., M. Gowen, andR. G. G. Russell. 1988. Interleukin 1 as a paracrine factor in bone: Effects on osteocalast-like cell formation and production by osteoblast-like cells.J. Bone Mineral Res. 3:S196.

Nishihara, T., Y. Ishihara, T. Noguchi, andT. Koga. 1989. Membrane IL-1 induced bone resorption in organ culture.J. Immunol. 143:1881?1886.

Feyen, J. H. M., P. Elsford, F. E. Di Padova, andU. Trechsel. 1989. Interleukin-6 is produced by bone and modulated by parathyroid hormone.J. Bone Mineral Res. 4:633?638.

Shen, V., G. Kohler, J. J. Jeffery, andW. A. Peck. 1988. Bone-resorbing agents promote and interferon-gamma inhibits bone cell collagenase production.J. Bone Mineral Res. 3:65?66.

Littlewood, A. J., L. A. Aarden, D. B. Evan, R. G. G. Russell, andM. Gowen. 1991. Human osteoblastlike cells do not respond to interleukin-6.J. Bone Mineral Res. 6:141?148.

Hanazawa, S., Y. Ohmori, S. Amano, K. Hirose, T. Miyoshi, M. Kumegawa, andS. Kitano. 1985. Spontaneous production of interleukin-1-like cytokine from a mouse osteoblastic cell line (MC3T3-E1).Biochem. Biophys. Res. Commun. 131:774?779.

Washington, L., D. L. Coleman, T. A. Einhorn, andM. Horowitz. 1988. Retinods regulate murine osteoblast colony stimulating factor secretion.J. Bone Mineral Res. 3:S223.

Horowitz, M. C., D. L. Coleman, J. T. Ryaby, andT. A. Einhorn. 1989. Osteotropic agents induce the differential secretion of granulocyte-macrophage colony-stimulating factor by the osteoblast cell line MC3T3-E1.J. Bone Mineral Res. 4:911?921.

Skjodt, H., T. Moller, AndS. F. Freiesleben. 1989. Human osteoblast-like cells expressing MHC class II determinants stimulate allogeneic and autologous peripheral blood mononuclear cells and functional as antigen-presenting cells.Immunology 68:416?420.

Centrella, M., andE. Canalis. 1985. Transforming and nontransforming growth factors are present in medium conditioned by fetal rat calvaria.Proc. Natl. Acad. Sci. U.S.A. 82:7335?7339.

Canalis, E., T. McCarthy, andM. Centrella. 1988. Growth factors and the regulation of bone remodeling.J. Clin. Invest. 81:227?281.