Effects of herb-partitioned moxibustion and electroacupuncture on serum indexes of intestinal fibrosis in rats with Crohn’s disease
Tóm tắt
To observe the impact of herb-partitioned moxibustion and electroacupuncture on hyaluronic acid (HA), procollagen III (PC III) and collagen IV (C IV) of intestinal fibrosis in rats with Crohn’s disease (CD), and discuss the effect and the mechanism of acupuncture on treating intestinal fibrosis of rats. SD rats were randomly divided into control group, model group, herb-partitioned moxibustion group, electroacupuncture group and medicine group. The model of CD was developed by trinitrobenzene sulfonic acid. Masson stain was used to observe the collagen fibers hyperplasia in colon and radioimmunoassay was adopted to detect the content of HA, PC III and C IV in serum. Compared with the control group, the proliferation of colonic collagen fibers, as well as the HA, PC III and C IV in serum increased in the model group. Compared with the model group, the expression of collagen fibers, serum HA, PC III and C IV decreased in the herb-partitioned moxibustion group, electroacupuncture group and medicine group. The expression of collagen fibers serum HA, PC III and C IV in the herb-partitioned moxibustion group were lower than in the electroacupuncture group and medicine group. Herb-partitioned moxibustion and electroacupuncture effectively improved the pathological state of intestinal fibrosis in rats with CD and reduced the content of HA, PC III and C IV in serum.
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