Effects of different courses of moxibustion treatment on intestinal flora and inflammation of a rat model of knee osteoarthritis

Yu, 2020, Complementary and alternative therapies for knee osteoarthritis: a protocol for systematic review and network meta-analysis, Medicine (Baltimore), 99, 23035, 10.1097/MD.0000000000023035 Vos, 2020, Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019, Lancet, 396, 1204, 10.1016/S0140-6736(20)30925-9 Bijlsma, 2011, Osteoarthritis: an update with relevance for clinical practice, Lancet, 377, 2115, 10.1016/S0140-6736(11)60243-2 Zacaron, 2018, Effects of laying on of hands with and without a spiritual context on pain and functionality of older women with knee osteoarthritis: study protocol for a randomized controlled trial, J Integr Med, 16, 106, 10.1016/j.joim.2018.02.002 Felson, 2000, Osteoarthritis: new insights. Part 2: treatment approaches, Ann Intern Med, 133, 726, 10.7326/0003-4819-133-9-200011070-00015 Silverstein, 2000, Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib long-term arthritis safety study, JAMA, 284, 1247, 10.1001/jama.284.10.1247 Zhao, 2014, Effectiveness of moxibustion treatment as adjunctive therapy in osteoarthritis of the knee: a randomized, double-blinded, placebo-controlled clinical trial, Arthritis Res Ther, 16, R133, 10.1186/ar4590 Choi, 2012, Moxibustion for the treatment of osteoarthritis: a systematic review and meta-analysis, Rheumatol Int, 32, 2969, 10.1007/s00296-012-2367-7 Li, 2016, Moxibustion treatment for knee osteoarthritis: a systematic review and meta-analysis, Medicine (Baltimore), 95, 10.1097/MD.0000000000003244 Choi, 2017, Moxibustion for the treatment of osteoarthritis: an updated systematic review and meta-analysis, Maturitas, 100, 33, 10.1016/j.maturitas.2017.03.314 Song, 2016, Moxibustion is an alternative in treating knee osteoarthritis: the evidence from systematic review and meta-analysis, Medicine (Baltimore), 95, e2790, 10.1097/MD.0000000000002790 Szychlinska, 2019, A correlation between intestinal microbiota dysbiosis and osteoarthritis, Heliyon, 5, e01134, 10.1016/j.heliyon.2019.e01134 Schott, 2018, Targeting the gut microbiome to treat the osteoarthritis of obesity, JCI Insight, 3, e95997, 10.1172/jci.insight.95997 Wu, 2019, Pathological relationship between intestinal flora and osteoarthritis and intervention mechanism of Chinese medicine, Chin J Integr Med, 25, 716, 10.1007/s11655-019-3224-2 Guss, 2019, The effects of metabolic syndrome, obesity, and the gut microbiome on load-induced osteoarthritis, Osteoarthritis Cartilage, 27, 129, 10.1016/j.joca.2018.07.020 Li, 2021, Effects of mild moxibustion on intestinal microbiome and NLRP3 inflammasome in rats with 5-fluorouracil-induced intestinal mucositis, J Integr Med, 19, 144, 10.1016/j.joim.2020.12.004 Chen, 2020, Effect of moxibustion on the intestinal flora of rats with knee osteoarthritis induced by monosodium iodoacetate, Evid Based Complement Alternat Med, 2020, 3196427 Pitcher, 2016, The monoiodoacetate model of osteoarthritis pain in the mouse, J Vis Exp, 111, 53746 Miyamoto, 2016, Intra-articular injection of mono-iodoacetate induces osteoarthritis of the hip in rats, BMC Musculoskelet Disord, 17, 132, 10.1186/s12891-016-0985-z Ma, 2018, A rat model of knee osteoarthritis suitable for electroacupuncture study, Exp Anim, 67, 271, 10.1538/expanim.17-0142 Asjid, 2019, Effect of platelet-rich plasma on Mankin scoring in chemically-induced animal model of osteoarthritis, J Coll Physicians Surg Pak, 29, 1067, 10.29271/jcpsp.2019.11.1067 Boer, 2019, Intestinal microbiome composition and its relation to joint pain and inflammation, Nat Commun, 10, 4881, 10.1038/s41467-019-12873-4 Kapoor, 2011, Role of proinflammatory cytokines in the pathophysiology of osteoarthritis, Nat Rev Rheumatol, 7, 33, 10.1038/nrrheum.2010.196 Liu, 2021, Macrophage migration inhibitory factor may play a protective role in osteoarthritis, Arthritis Res Ther, 23, 59, 10.1186/s13075-021-02442-w Helmark, 2010, Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial, Arthritis Res Ther, 12, R126, 10.1186/ar3064 Järvinen, 2008, Selective iNOS inhibitor 1400W enhances anti-catabolic IL-10 and reduces destructive MMP-10 in OA cartilage. Survey of the effects of 1400W on inflammatory mediators produced by OA cartilage as detected by protein antibody array, Clin Exp Rheumatol, 26, 275 Botha-Scheepers, 2008, Innate production of tumour necrosis factor α and interleukin 10 is associated with radiological progression of knee osteoarthritis, Ann Rheum Dis, 67, 1165, 10.1136/ard.2007.084657 Watkins, 2020, Targeted interleukin-10 plasmid DNA therapy in the treatment of osteoarthritis: toxicology and pain efficacy assessments, Brain Behav Immun, 90, 155, 10.1016/j.bbi.2020.08.005 Chen, 2020, Effect of moxibustion on inflammatory factors and oxidative stress factors in patients with knee osteoarthritis: a randomized controlled trial, Zhongguo Zhen Jiu, 40, 913 Udo, 2016, Monoiodoacetic acid induces arthritis and synovitis in rats in a dose- and time-dependent manner: proposed model-specific scoring systems, Osteoarthritis Cartilage, 24, 1284, 10.1016/j.joca.2016.02.005 Chen, 2021, Ligustrum robustum (Roxb.) Blume extract modulates gut microbiota and prevents metabolic syndrome in high-fat diet-fed mice, J Ethnopharmacol, 268, 113695, 10.1016/j.jep.2020.113695 Derrien, 2008, The mucin degrader Akkermansia muciniphila is an abundant resident of the human intestinal tract, Appl Environ Microbiol, 74, 1646, 10.1128/AEM.01226-07 Schneeberger, 2015, Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice, Sci Rep, 5, 16643, 10.1038/srep16643 Clemente, 2018, The role of the gut microbiome in systemic inflammatory disease, BMJ, 360 Darnaud, 2018, Enteric delivery of regenerating family member 3 α alters the intestinal microbiota and controls inflammation in mice with colitis, Gastroenterology, 154, 1009, 10.1053/j.gastro.2017.11.003 Dong, 2019, Red yeast rice ameliorates high-fat diet-induced atherosclerosis in Apoe-/- mice in association with improved inflammation and altered gut microbiota composition, Food Funct, 10, 3880, 10.1039/C9FO00583H Du, 2012, Ingredients of Huangqi decoction slow biliary fibrosis progression by inhibiting the activation of the transforming growth factor-β signaling pathway, BMC Complement Altern Med, 12, 33, 10.1186/1472-6882-12-33 Zhuge, 2020, Lactobacillus salivarius LI01 encapsulated in alginate-pectin microgels ameliorates D-galactosamine-induced acute liver injury in rats, Appl Microbiol Biotechnol, 104, 7437, 10.1007/s00253-020-10749-y Si, 2018, Gut microbiome-induced shift of acetate to butyrate positively manages dysbiosis in high fat diet, Mol Nutr Food Res, 62, 1700670, 10.1002/mnfr.201700670 Qin, 2021, RS5 produced more butyric acid through regulating the microbial community of human gut microbiota, J Agric Food Chem, 69, 3209, 10.1021/acs.jafc.0c08187 Tian, 2021, Lycium ruthenicum anthocyanins attenuate high-fat diet-induced colonic barrier dysfunction and inflammation in mice by modulating the gut microbiota, Mol Nutr Food Res, 65, e2000745, 10.1002/mnfr.202000745 Hu, 2020, Characterizing the gut microbiota in patients with chronic kidney disease, Postgrad Med, 132, 495, 10.1080/00325481.2020.1744335 Ohira, 2017, Are short chain fatty acids in gut microbiota defensive players for inflammation and atherosclerosis?, J Atheroscler Thromb, 24, 660, 10.5551/jat.RV17006