Effects of ascorbic acid on impaired vascular reactivity in aortas isolated from age-matched hypertensive and diabetic rats

Ajay, 2006, Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aortas: comparative study with ascorbic acid, Clin. Exp. Pharmacol. Physiol., 33, 345, 10.1111/j.1440-1681.2006.04373.x Ajay, 2006, Effect of quercetin on altered vascular reactivity in aorta isolated from streptozotocin-induced diabetic rats, Diabetes Res. Clin. Pract., 73, 1, 10.1016/j.diabres.2005.11.004 Akpaffiong, 1998, Antihypertensive and vasodilator actions of antioxidants in spontaneously hypertensive rats, Am. J. Hypertens., 11, 1450, 10.1016/S0895-7061(98)00183-6 Beetens, 1986, Vitamin C increases the prostacyclin production and decreases the vascular lesions in experimental atherosclerosis in rabbits, Prostaglandins, 32, 335, 10.1016/0090-6980(86)90003-1 Ceriello, 1991, Anti-oxidants show an anti-hypertensive effect in diabetic and hypertensive subjects, Clin. Sci., 81, 739, 10.1042/cs0810739 Chang, 1993, Possible superoxide-radical-induced alterations of vascular reactivity in aortas from streptozotocin-treated rats, J. Pharmacol. Exp. Ther., 266, 992 Chang, 1993, Endothelial potentiation of relaxation response to ascorbic acid in rat and guinea pig thoracic aorta, Life Sci., 52, PL37, 10.1016/0024-3205(93)90156-W Craven, 1994, Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response, J. Clin. Invest., 93, 311, 10.1172/JCI116961 Darko, 2002, Lack of effect of oral vitamin C on blood pressure, oxidative stress, and endothelial function in type II diabetes, Clin. Sci., 103, 339, 10.1042/cs1030339 Dresner, 1997, Nitric oxide inhibition simulates the enhancement of α1-agonist-induced vasoconstriction in diabetes, J. Surg. Res., 70, 119, 10.1006/jsre.1997.5106 Endemann, 2004, Endothelial dysfunction, J. Am. Soc. Nephrol., 15, 1983, 10.1097/01.ASN.0000132474.50966.DA Frei, 1990, Ascorbate: the most effective antioxidant in human blood plasma, Adv. Exp. Med. Biol., 264, 155, 10.1007/978-1-4684-5730-8_24 Furchgott, 1989, Endothelium-derived relaxing and contracting factors, FASEB J., 3, 2007, 10.1096/fasebj.3.9.2545495 Gewaltig, 2002, Vasoprotection by nitric oxide: mechanisms and therapeutic potential, Cardiovasc. Res., 55, 250, 10.1016/S0008-6363(02)00327-9 Godfraind, 1985, Role of endothelium in the contractile response of rat aorta to alpha-adrenergic agonists, Clin. Sci., 68, 65s, 10.1042/cs068s065 Grossmann, 2001, Ascorbic acid-induced modulation of venous tone in humans, Hypertension, 37, 949, 10.1161/01.HYP.37.3.949 Jackson, 1998, Ascorbic acid prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations, Circ. Res., 83, 916, 10.1161/01.RES.83.9.916 Jones, 1986, Ascorbic acid-inhibition of alpha-adrenergic receptor binding, Biochem. Pharmacol., 35, 595, 10.1016/0006-2952(86)90353-9 Kagota, 2001, Down regulation of vascular soluble guanylate cyclase induced by high salt intake in spontaneously hypertensive rats, Br. J. Pharmacol., 134, 737, 10.1038/sj.bjp.0704300 Kapeghian, 1984, The effects of glucose on ascorbic acid uptake in heart endothelial cells: possible pathogenesis of diabetic angiopathies, Life Sci., 34, 577, 10.1016/0024-3205(84)90491-0 Malo, 2000, Glucose modulates vitamin C transport in adult human small intestinal brush border membrane vesicles, J. Nutr., 130, 63, 10.1093/jn/130.1.63 May, 2000, How does ascorbic acid prevent endothelial dysfunction?, Free Radical Biol. Med., 28, 1421, 10.1016/S0891-5849(00)00269-0 Mullan, 2002, Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes, Hypertension, 40, 804, 10.1161/01.HYP.0000039961.13718.00 Nascimento, 2003, Free radical scavengers improve the impaired endothelium-dependent responses in aorta and kidneys of diabetic rabbits, Diabetes Res. Clin. Pract., 61, 145, 10.1016/S0168-8227(03)00128-1 Pieper, 1997, Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals, Cardiovasc. Res., 34, 145, 10.1016/S0008-6363(96)00237-4 Price, 2001, Hyperglycemia-induced ascorbic acid deficiency promotes endothelial dysfunction and the development o atherosclerosis, Atherosclerosis, 158, 1, 10.1016/S0021-9150(01)00569-X Sekiguchi, 2004, Superoxide dismutase reduces the impairment of endothelium-dependent relaxation in the spontaneously hypertensive rat aorta, J. Smooth Muscle Res., 40, 65, 10.1540/jsmr.40.65 Taddei, 1998, Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension, Circulation, 97, 2222, 10.1161/01.CIR.97.22.2222 Ting, 1996, Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin dependent diabetes mellitus, J. Clin. Invest., 97, 22, 10.1172/JCI118394 Toivanen, 1987, Effects of selenium, vitamin E, and vitamin C on human prostacyclin and thromboxane synthesis in vitro, Prostaglandins Leukot. Med., 26, 265, 10.1016/0262-1746(87)90036-9 Vasdev, 2002, Dietary vitamin E and C supplementation prevents fructose induced hypertension in rats, Mol. Cell. Biochem., 241, 107, 10.1023/A:1020835229591 Weber, 1997, Influence of streptozotocin diabetes on alpha-1 adrenoceptor and associated G proteins in rat arteries, J. Pharmacol. Exp. Ther., 283, 1469