Effects of aromatherapy on agitation and related caregiver burden in patients with moderate to severe dementia: A pilot study

Selekler, 2003 Cummings, 2007 Khoo, 2013, The impact of neuropsychiatric symptoms on caregiver distress and quality of life in persons with dementia in an Asian tertiary hospital memory clinic, Int Psychogeriatr, 25, 1991, 10.1017/S1041610213001518 Meziere, 2013, Neuropsychiatric symptoms in elderly inpatients: a multicenter cross-sectional study, Dement Geriatr Cogn Dis Extra, 3, 123, 10.1159/000350805 Eker, 2008, İ.Ü. Cerrahpaşa Tıp Fakültesi Sürekli Tıp Eğitimi Etkinlikleri, 62, 85 Hendriks, 2014, Dying with dementia: symptoms, treatment, and quality of life in the last week of life, J Pain Symptom Manage, 47, 710, 10.1016/j.jpainsymman.2013.05.015 Noyan, 2012, Management of the elderly with behavior disturbances, Ege Tip Derg, 51, 31 O'Connor, 2013, A randomized, controlled cross-over trial of dermally-applied lavender (Lavandula angustifolia) oil as a treatment of agitated behaviour in dementia, BMC Complement Altern Med, 13, 315, 10.1186/1472-6882-13-315 Yazgan, 2003, Huzurevlerinde ajitasyon: Nedenleri ve başa çıkma yolları, Demans Derg, 3, 81 Emanuel, 2011 Livingston, 2014, A systematic review of the clinical effectiveness and cost-effectiveness of sensory, psychological and behavioural interventions for managing agitation in older adults with dementia, Health Technol Assess, 18, 1, 10.3310/hta18610 Langa, 2001, National estimates of the quantity and cost of informal caregiving for the elderly with dementia, J Gen Intern Med, 16, 770, 10.1111/j.1525-1497.2001.10123.x Donaldson, 1999, Burden of Alzheimer's disease: helping the patient and caregiver, J Geriatr Psychiatry Neurol, 12, 21, 10.1177/089198879901200106 Erder, 2012, A new measure of caregiver burden in Alzheimer's disease: the caregiver-perceived burden questionnaire, Am J Alzheimers Dis Other Demen, 27, 474, 10.1177/1533317512456449 Gaugler, 2011, Does caregiver burden mediate the effects of behavioral disturbances on nursing home admission?, Am J Geriatr Psychiatry, 19, 497, 10.1097/JGP.0b013e31820d92cc 2006 2006 Trifiro, 2009, Use of antipsychotics in elderly patients with dementia: do atypical and conventional agents have a similar safety profile?, Pharmacol Res, 59, 1, 10.1016/j.phrs.2008.09.017 Cohen-Mansfield, 2001, Nonpharmacologic interventions for inappropriate behaviors in dementia: a review, summary, and critique, Am J Geriatr Psychiatry, 9, 361, 10.1097/00019442-200111000-00005 Ballard, 2002, Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa, J Clin Psychiatry, 63, 553, 10.4088/JCP.v63n0703 Yang, 2015, Comparison of the efficacy of aroma-acupressure and aromatherapy for the treatment of dementia-associated agitation, BMC Complement Altern Med, 15, 93, 10.1186/s12906-015-0612-9 Fu, 2013, A randomised controlled trial of the use of aromatherapy and hand massage to reduce disruptive behaviour in people with dementia, BMC Complement Altern Med, 13, 165, 10.1186/1472-6882-13-165 Fujii, 2008, Lavender aroma therapy for behavioral and psychological symptoms in dementia patients, Geriatr Gerontol Int, 8, 136, 10.1111/j.1447-0594.2008.00461.x Lee, 2005, The effect of lavender aromatherapy on cognitive function, emotion, and aggressive behavior of elderly with dementia, Taehan Kanho Hakhoe Chi, 35, 303 Lin, 2007, Efficacy of aromatherapy (Lavandula angustifolia) as an intervention for agitated behaviours in Chinese older persons with dementia: a cross-over randomized trial, Int J Geriatr Psychiatry, 22, 405, 10.1002/gps.1688 Smallwood, 2001, Aromatherapy and behaviour disturbances in dementia: a randomized controlled trial, Int J Geriatr Psychiatry, 16, 1010, 10.1002/gps.473 Buckle, 2015 Blanco, 2009, Neurobehavioral effect of essential oil of Cymbopogon citratus in mice, Phytomedicine, 16, 265, 10.1016/j.phymed.2007.04.007 Costa, 2011, The GABAergic system contributes to the anxiolytic-like effect of essential oil from Cymbopogon citratus (lemongrass), J Ethnopharmacol, 137, 828, 10.1016/j.jep.2011.07.003 Goes, 2015, Effect of lemongrass aroma on experimental anxiety in humans, J Altern Complement Med, 21, 766, 10.1089/acm.2015.0099 Gray, 2002, Influence of aromatherapy on medication administration to residential-care residents with dementia and behavioral challenges, Am J Alzheimers Dis Other Demen, 17, 169, 10.1177/153331750201700305 Snow, 2004, A controlled trial of aromatherapy for agitation in nursing home patients with dementia, J Altern Complement Med, 10, 431, 10.1089/1075553041323696 Forrester, 2014, Aromatherapy for dementia, Cochrane Database Syst Rev, CD003150 Burns, 2011, A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease, Dement Geriatr Cogn Disord, 31, 158, 10.1159/000324438 Faul, 2007, G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences, Behav Res Methods, 39, 175, 10.3758/BF03193146 Akyar, 2009, Strains of caregivers of alzheimer patients, Sağlık Bilim Fakültesi Hemşirelik Derg, 16, 32 Tasdemir, 2011, Home follow-up of early- and mid-stage Alzheimer's patients, J Psychiatr Ment Health Nurs, 18, 767, 10.1111/j.1365-2850.2011.01724.x Cummings, 1994, The neuropsychiatric inventory: Comprehensive assessment of psychopathology in dementia, Neurology, 44, 2308, 10.1212/WNL.44.12.2308 Akça-Kalem, 2005, Validation study of the Turkish translation of the frontal behavioral inventory (FBI) Cohen-Mansfield, 1989, A description of agitation in a nursing home, J Gerontol, 44, M77, 10.1093/geronj/44.3.M77 Özel-Kızıl, 2012, Psychometric properties of the Turkish version of Cohen- Mansfield agitation inventory in patients with dementia, Turk J Geriatr, 15, 24 Zarit, 1980, Relatives of the impaired elderly: correlates of feelings of burden, Gerontologist, 20, 649, 10.1093/geront/20.6.649 İnci, 2008, Validity and reliability of the burden interview and its adaptation to Turkish, J Anatol Nurs Health Sci, 11, 85 Snyder, 1995, Efficacy of hand massage in decreasing agitation behaviors associated with care activities in persons with dementia, Geriatr Nurs, 16, 60, 10.1016/S0197-4572(05)80005-9 Schwarz, 2012, Pharmacological treatment of dementia, Curr Opin Psychiatry, 25, 542, 10.1097/YCO.0b013e328358e4f2 Jimbo, 2009, Effect of aromatherapy on patients with Alzheimer's disease, Psychogeriatrics, 9, 173, 10.1111/j.1479-8301.2009.00299.x Özel-Kızıl, 2014, The effect of agitation on caregivers' burden in patients with dementia, Turk J Geriatr, 17, 256