Effects of androgen and leptin on behavioral and cellular responses in female rats

Hormones and Behavior - Tập 60 - Trang 427-438 - 2011
Yi Feng1,2, Ruijin Shao1, Birgitta Weijdegård1, Tienpei Wang3, Julia Johansson1, Shan Sun4, Wei Wang1, Emil Egecioglu1, Håkan Billig1, Elisabet Stener-Victorin1,5
1Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
2Department of Integrative Medicine and Neurobiology, State Key Lab of Medical Neurobiology, Shanghai Medical College; Institute of Acupuncture Research, Institutes of Brain Science, Fudan University, Shanghai, China
3Department of Acupuncture and Moxibustion, Hubei College of Traditional Chinese Medicine, Wuhan, China
4Central Medical Lab, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, China
5Department of Obstetrics and Gynaecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China

Tài liệu tham khảo

Adali, 2008, The relationship between clinico-biochemical characteristics and psychiatric distress in young women with polycystic ovary syndrome, J. Int. Med. Res., 36, 1188, 10.1177/147323000803600604 Azziz, 2004, Androgen excess in women: experience with over 1000 consecutive patients, J. Clin. Endocrinol. Metab., 89, 453, 10.1210/jc.2003-031122 Barnard, 2007, Quality of life and psychological well being in polycystic ovary syndrome, Hum. Reprod., 22, 2279, 10.1093/humrep/dem108 Benson, 2009, Prevalence and implications of anxiety in polycystic ovary syndrome: results of an internet-based survey in Germany, Hum. Reprod., 24, 1446, 10.1093/humrep/dep031 Bjorbaek, 2009, Central leptin receptor action and resistance in obesity, J. Investig. Med., 57, 789, 10.2310/JIM.0b013e3181bb0d49 Coffey, 2006, Health-related quality of life in women with polycystic ovary syndrome: a comparison with the general population using the Polycystic Ovary Syndrome Questionnaire (PCOSQ) and the Short Form-36 (SF-36), Gynecol. Endocrinol., 22, 80, 10.1080/09513590600604541 Coppari, 2005, The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity, Cell Metab., 1, 63, 10.1016/j.cmet.2004.12.004 Deeks, 2010, Anxiety and depression in polycystic ovary syndrome: a comprehensive investigation, Fertil. Steril., 93, 2421, 10.1016/j.fertnstert.2009.09.018 Elmquist, 1998, Distributions of leptin receptor mRNA isoforms in the rat brain, J. Comp. Neurol., 395, 535, 10.1002/(SICI)1096-9861(19980615)395:4<535::AID-CNE9>3.0.CO;2-2 Elsenbruch, 2003, Quality of life, psychosocial well-being, and sexual satisfaction in women with polycystic ovary syndrome, J. Clin. Endocrinol. Metab., 88, 5801, 10.1210/jc.2003-030562 Fan, 2008, Functional potentiation of leptin-signal transducer and activator of transcription 3 signaling by the androgen receptor, Endocrinology, 149, 6028, 10.1210/en.2008-0431 Fei, 1997, Anatomic localization of alternatively spliced leptin receptors (Ob–R) in mouse brain and other tissues, Proc. Natl. Acad. Sci. U. S. A., 94, 7001, 10.1073/pnas.94.13.7001 Feng, 2009, Hypothalamic neuroendocrine functions in rats with dihydrotestosterone-induced polycystic ovary syndrome: effects of low-frequency electro-acupuncture, PLoS One, 4, e6638, 10.1371/journal.pone.0006638 Feng, 2010, Spatiotemporal expression of androgen receptors in the female rat brain during the oestrous cycle and the impact of exogenous androgen administration: a comparison with gonadally intact males, Mol. Cell. Endocrinol., 321, 161, 10.1016/j.mce.2010.02.029 Foecking, 2008, Neuroendocrine consequences of androgen excess in female rodents, Horm. Behav., 53, 673, 10.1016/j.yhbeh.2007.12.013 Frye, 2008, Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice, Horm. Behav., 54, 726, 10.1016/j.yhbeh.2008.07.013 Gao, 2005, Chemistry and structural biology of androgen receptor, Chem. Rev., 105, 3352, 10.1021/cr020456u Handa, 2008, An alternate pathway for androgen regulation of brain function: activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5alpha-androstane-3beta,17beta-diol, Horm. Behav., 53, 741, 10.1016/j.yhbeh.2007.09.012 Handa, 2009, A role for the androgen metabolite, 5alpha-androstane-3beta,17beta-diol, in modulating oestrogen receptor beta-mediated regulation of hormonal stress reactivity, J. Neuroendocrinol., 21, 351, 10.1111/j.1365-2826.2009.01840.x Hart, 2010, Experimental models of anxiety for drug discovery and brain research, Methods Mol. Biol., 602, 299, 10.1007/978-1-60761-058-8_18 Hollinrake, 2007, Increased risk of depressive disorders in women with polycystic ovary syndrome, Fertil. Steril., 87, 1369, 10.1016/j.fertnstert.2006.11.039 Huo, 2009, Leptin-dependent control of glucose balance and locomotor activity by POMC neurons, Cell Metab., 9, 537, 10.1016/j.cmet.2009.05.003 Jedel, 2011, Sex steroids, insulin sensitivity and sympathetic nerve activity in relation to affective symptoms in women with polycystic ovary syndrome, Psychoneuroendocrinology, 10.1016/j.psyneuen.2011.04.001 Jedel, 2010, Anxiety and depression symptoms in women with polycystic ovary syndrome compared with controls matched for body mass index, Hum. Reprod., 25, 450, 10.1093/humrep/dep384 Jedel, 2010, Anxiety and depression symptoms in women with polycystic ovary syndrome compared with controls matched for body mass index, Hum. Reprod., 25, 450, 10.1093/humrep/dep384 Johansson, 2010, Intense acupuncture normalizes insulin sensitivity, increases muscle GLUT4 content, and improves lipid profile in a rat model of polycystic ovary syndrome, Am. J. Physiol. Endocrinol. Metab., 299, E551, 10.1152/ajpendo.00323.2010 Kerchner, 2009, Risk of depression and other mental health disorders in women with polycystic ovary syndrome: a longitudinal study, Fertil. Steril., 91, 207, 10.1016/j.fertnstert.2007.11.022 Leshan, 2006, Leptin receptor signaling and action in the central nervous system, Obesity, 14, 208S, 10.1038/oby.2006.310 Lu, 2006, Leptin: a potential novel antidepressant, Proc. Natl. Acad. Sci. U. S. A., 103, 1593, 10.1073/pnas.0508901103 Lund, 2005, Novel actions of estrogen receptor-beta on anxiety-related behaviors, Endocrinology, 146, 797, 10.1210/en.2004-1158 Manneras, 2007, A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome, Endocrinology, 148, 3781, 10.1210/en.2007-0168 Manneras, 2009, Acupuncture and exercise restore adipose tissue expression of sympathetic markers and improve ovarian morphology in rats with dihydrotestosterone-induced PCOS, Am. J. Physiol. Regul. Integr. Comp. Physiol., 296, R1124, 10.1152/ajpregu.90947.2008 Manneras, 2008, Low-frequency electro-acupuncture and physical exercise improve metabolic disturbances and modulate gene expression in adipose tissue in rats with dihydrotestosterone-induced polycystic ovary syndrome, Endocrinology, 149, 3559, 10.1210/en.2008-0053 Mansson, 2008, Women with polycystic ovary syndrome are often depressed or anxious—a case control study, Psychoneuroendocrinology, 33, 1132, 10.1016/j.psyneuen.2008.06.003 Myers, 2008, Mechanisms of leptin action and leptin resistance, Annu. Rev. Physiol., 70, 537, 10.1146/annurev.physiol.70.113006.100707 Nohara, 2011, Early-life exposure to testosterone programs the hypothalamic melanocortin system, Endocrinology, 10.1210/en.2010-1288 Norman, 2007, Polycystic ovary syndrome, Lancet, 370, 685, 10.1016/S0140-6736(07)61345-2 Obici, 2009, Minireview: molecular targets for obesity therapy in the brain, Endocrinology, 150, 2512, 10.1210/en.2009-0409 Paxinos, 2009 Postma, 2000, Effects of testosterone administration on selective aspects of object–location memory in healthy young women, Psychoneuroendocrinology, 25, 563, 10.1016/S0306-4530(00)00010-X Pusalkar, 2010, Obesity and polycystic ovary syndrome: association with androgens, leptin and its genotypes, Gynecol Endocrinol, 26, 874, 10.3109/09513590.2010.487586 Rasgon, 2003, Depression in women with polycystic ovary syndrome: clinical and biochemical correlates, J. Affect. Disord., 74, 299, 10.1016/S0165-0327(02)00117-9 Raskin, 2009, Conditional inactivation of androgen receptor gene in the nervous system: effects on male behavioral and neuroendocrine responses, J. Neurosci., 29, 4461, 10.1523/JNEUROSCI.0296-09.2009 Rohr, 2002, The impact of testosterone imbalance on depression and women's health, Maturitas, 41, S25, 10.1016/S0378-5122(02)00013-0 Shao, 2007, Estrogen-induced upregulation of AR expression and enhancement of AR nuclear translocation in mouse fallopian tubes in vivo, Am. J. Physiol. Endocrinol. Metab., 292, E604, 10.1152/ajpendo.00350.2006 Sharma, 2010, Neurobehavioral deficits in db/db diabetic mice, Physiol. Behav., 101, 381, 10.1016/j.physbeh.2010.07.002 Steckler, 1999, Glucocorticoids and depression, Baillieres Best Pract. Res. Clin. Endocrinol. Metab., 13, 597, 10.1053/beem.1999.0046 Stener-Victorin, 2010, Are there any sensitive and specific sex steroid markers for polycystic ovary syndrome?, J. Clin. Endocrinol. Metab., 95, 810, 10.1210/jc.2009-1908 Taylor, 2010, The role of adipokines in understanding the associations between obesity and depression, J. Obes., 10.1155/2010/748048 Walf, 2005, ERbeta-selective estrogen receptor modulators produce antianxiety behavior when administered systemically to ovariectomized rats, Neuropsychopharmacology, 30, 1598, 10.1038/sj.npp.1300713 Walf, 2008, Estradiol or diarylpropionitrile decrease anxiety-like behavior of wildtype, but not estrogen receptor beta knockout, mice, Behav. Neurosci., 122, 974, 10.1037/a0012749 Walters, 2009, Subfertile female androgen receptor knockout mice exhibit defects in neuroendocrine signaling, intraovarian function, and uterine development but not uterine function, Endocrinology, 150, 3274, 10.1210/en.2008-1750 Weiner, 2004, Androgens and mood dysfunction in women: comparison of women with polycystic ovarian syndrome to healthy controls, Psychosom. Med., 66, 356 Weisz, 1980, Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses, and neonatal offspring, Endocrinology, 106, 306, 10.1210/endo-106-1-306 Yildiz, 2008, Impact of obesity on the risk for polycystic ovary syndrome, J. Clin. Endocrinol. Metab., 93, 162, 10.1210/jc.2007-1834 Zuloaga, 2008, Mice with the testicular feminization mutation demonstrate a role for androgen receptors in the regulation of anxiety-related behaviors and the hypothalamic–pituitary–adrenal axis, Horm. Behav., 54, 758, 10.1016/j.yhbeh.2008.08.004