Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ?fear?-motivated behaviour

Sheila L. Handley1, Siddika Mithani1
1Pharmacology Laboratories, Department of Pharmacy, University of Aston, Birmingham, UK

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Baust W, Niemezyk H, Vieth J (1963) The action of blood pressure on the ascending reticular activating system with special reference to adrenaline induced arousal. Electroenceph Clin Neurophysiol 15:63?72

Bradshaw CM, Stoker MJ, Szabadi E (1982) The effect of microelectrophoretically applied clonidine on single cerebral cortical neurones in the rat. Evidence for interaction with -?1-adrenoceptors. Naunyn-Schmiedeberg's Arch Pharmacol 320:230?234

Bugajski J, Zacyn E, Zdebska A (1980) The involvement of central adrenergic and histamine H2 receptors in the hypothermia induced by clonidine in the rat. Neuropharmacology 19:9?15

Cavero J, Lefevre F, Roach AG (1977) Differential effects of prazosin in the pre- and postsynaptic ?-adrenoceptors in the rat and dog. Br J Pharmacol 61:469P

Charney DS, Heninger GR, Redmond Jr DE (1983) Yohimbine induced anxiety and increased noradrenergic functions in humans: Effects of diazepam and clonidine. Life Sciences 33:19?30

Davis M, Astrachan DI (1981) Spinal modulation of acousticstartle: Opposite effects of clonidine and d-amphetamine. Psychopharmacology 75:219?225

Davis M, Cedarbaum JM, Aghajanian GK, Gendelman DS (1977) Effects of clonidine on habituation and sensitization of acoustic startle in normal, decerebrate and LC lesioned rats. Psychopharmacology 51:243?253

De Jonge A, van Meel JCA, Timmermans PBMWM, van Zweiten PA (1981) A lipophilic, selective ?1-adrenoceptor agonist: 2-(2-chloro-5-trifluoromethyl phenylimino)imidazoline (St587). Life Sciences 28:2009?2016

Dedek J, Scatton B, Zivkovic B (1981) Yohimbine blocks dopaminergic transmission in the rat striatum. Br J Pharmacol 73:239P

Doxey JC, Roach AG, Smith CFC (1983) Studies on RX781094; a selective, potent and specific antagonist of ?2-adrenoceptors. Br J Pharmacol 78:489?506

Drew GM (1976) Effects of ?-adrenoceptor agonists and antagonists on pre- and postsynaptically located ?-adrenoceptors. Eur J Pharmacol 36:313?320

File SE, Lister RG (1983) Anxiogenic action of picrotoxin and pentylenetetrazole: reversal by chlordiazepoxide. Br J Pharmacol 79:286P

File SE, Vellucci SV (1978) Studies on the role of ACTH and of 5-HT in anxiety, using an animal model. J Pharm Pharmacol 30:105?110

Goldenberg M, Snyder CH, Aranon Jr H (1947) New test for hypertension due to circulating epinephrine. JAMA 135:971?976

Hoehn-Saric R, Merchant AF, Keyser MC, Smith VK (1981) Effects of clonidine on anxiety disorders. Arcj Gen Psychiatry 38:1278?1286

Holmberg G, Gershon S (1961) Autonomic and psychic effects of yohimbine hydrochloride. Psychopharmacology 2:93?106

Kruse H, Dunn RW, Theurer KL, Novick WJ, Shearman GT (1981) Attenuation of conflict induced suppression by clonidine: Indication of anxiolytic activity. Drug Dev Research 1:137?143

Margolis R, Prieto P, Stein L, Chin S (1971) Statistical summary of 10,000 male cases using afrodex in the treatment of impotence. Current Therap Research 13:616?622

Michel AD, Nahorski SR, Whiting RL (1981) Selectivity of RS21361 fo ?2-adrenoceptors as determined by in vitro, in vivo and ligand binding studies. Br J Pharmacol 74:845 p

Montgomery KC (1955) The relation between fear induced by novel stimulation and exploratory behaviour. J Comp Physiol Psychol 48:254?260

Papeschi R, Sourkes TL, Youdim MBH (1971) The effect of yohimbine on brain serotonin metabolism, motor behaviour and body temperature of the rat. Eur J Pharmacol 15:318?326

Redmond DE, Huang YH (1979) Current concepts II: New evidence for a locus coeruleus-norepinephrine connection with anxiety. Life Sciences 25:2149?2162

Soffer A (1954) Rogitine and benodaine in the diagnosis of phaeochromocytoma. Med Clin North America 38:374?384

Starke K, Borowski E, Endo T (1975) Preferential blockade of presynaptic ?-adrenoceptors by yohimbine. Eur J Pharmacol 34:385?388