Effects of Selenium Supplementation on the Indices of Disease Activity, Inflammation and Oxidative Stress in Patients with Rheumatoid Arthritis: a Randomized Clinical Trial
Biological Trace Element Research - Trang 1-11 - 2023
Tóm tắt
The aim of study was to evaluate the effect of selenium supplementation on disease activity, inflammation, and oxidative stress in patients with rheumatoid arthritis (RA). This study was a randomized double-blind placebo-controlled trial on 59 patients with RA. Participants were randomly divided to receive 200 μg/day of selenium or a placebo for 12 weeks. The disease activity score (DAS.CRP and DAS.ESR), erythrocyte sedimentation rate (ESR), serum levels of C-reactive protein (CRP), fasting blood glucose, lipids, antibodies to cyclic citrullinated protein (anti-CCP), nitric oxide, glutathione, and total antioxidant capacity were assessed. The mean of DAS.CRP and DAS.ESR decreased significantly within both study groups after the intervention. However, the between-group comparisons revealed no significant differences. The CRP levels decreased significantly in the selenium group, and this decrease was near the significance level compared to the placebo (P = 0.05). However, after adjusting for baseline values, the observed difference between groups did not remain significant. In addition, the values of ESR and anti-CCP decreased significantly within the selenium group. Although, between-group comparison did not statistically significant, the change in ESR and anti-CCP in the selenium group was small clinically relevant compared to the placebo [the effect size (95% CI) for ESR: 0.38 (− 0.14, 0.89), and for anti-CCP: 0.32 (− 0.2, 0.83)]. Our study showed that selenium caused a small clinically relevant improvement in some RA biomarkers such as ESR and anti-CCP. Future studies that evaluate the effects of novel forms of supplements such as selenium nanoparticles on the clinical symptoms and biomarkers of RA are suggested. Trial Registration: At
www.irct.ir
as IRCT20190924044869N1 on 2020–06-14.
Tài liệu tham khảo
Wesolowski LT, Semanchik PL, White-Springer SH (2022) Beyond antioxidants: selenium and skeletal muscle mitochondria. Front Vet Sci 9:1011159. https://doi.org/10.3389/fvets.2022.1011159
Mutonhodza B, Joy EJM, Bailey EH, Lark MR, Kangara MGM, Broadley MR et al (2022) Linkages between soil, crop, livestock, and human selenium status in sub-Saharan Africa: a scoping review. Int J Food Sci Technol 57(10):6336–6349. https://doi.org/10.1111/ijfs.15979
Lei XG, Combs GF Jr, Sunde RA, Caton JS, Arthington JD, Vatamaniuk MZ (2022) Dietary selenium across species. Annu Rev Nutr 42:337–375. https://doi.org/10.1146/annurev-nutr-062320-121834
Xu D, Li W, Huang Y, He J, Tian Y (2014) The effect of selenium and polysaccharide of Atractylodes macrocephala Koidz. (PAMK) on immune response in chicken spleen under heat stress. Biol Trace Elem Res 160(2):232–237. https://doi.org/10.1007/s12011-014-0056-y
Xu D, Tian Y (2015) Selenium and polysaccharides of atractylodes macrocephala koidz play different roles in improving the immune response induced by heat stress in chickens. Biol Trace Elem Res 168(1):235–241. https://doi.org/10.1007/s12011-015-0351-2
Yao HD, Wu Q, Zhang ZW, Li S, Wang XL, Lei XG et al (2013) Selenoprotein W serves as an antioxidant in chicken myoblasts. Biochim Biophys Acta 1830(4):3112–3120. https://doi.org/10.1016/j.bbagen.2013.01.007
Rayman MP (2000) The importance of selenium to human health. Lancet 356(9225):233–241. https://doi.org/10.1016/s0140-6736(00)02490-9
Arbogast S, Ferreiro A (2010) Selenoproteins and protection against oxidative stress: selenoprotein N as a novel player at the crossroads of redox signaling and calcium homeostasis. Antioxid Redox Signal 12(7):893–904. https://doi.org/10.1089/ars.2009.2890
Huang Z, Rose AH, Hoffmann PR (2012) The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 16(7):705–743. https://doi.org/10.1089/ars.2011.4145
Mistry HD, Broughton Pipkin F, Redman CW, Poston L (2012) Selenium in reproductive health. Am J Obstet Gynecol 206(1):21–30. https://doi.org/10.1016/j.ajog.2011.07.034
Rayman MP (2012) Selenium and human health. Lancet 379(9822):1256–1268. https://doi.org/10.1016/s0140-6736(11)61452-9
Karlson EW, Shadick NA, Cook NR, Buring JE, Lee IM (2008) Vitamin E in the primary prevention of rheumatoid arthritis: the women’s health study. Arthritis Rheum 59(11):1589–1595. https://doi.org/10.1002/art.24194
Schirmer M (2016) Immune system and rheumatic diseases in the elderly. Dtsch Med Wochenschr 141(11):794–796. https://doi.org/10.1055/s-0042-103513
Anandarajah AP (2011) Clinical aspects of rheumatoid arthritis: highlights from the 2010 ACR conference. Int J Clin Rheumatol 6(3):267
Conceição CS, Gomes Neto M, Mendes SM, Sá KN, Baptista AF (2015) Systematic review and meta-analysis of effects of foot orthoses on pain and disability in rheumatoid arthritis patients. Disabil Rehabil 37(14):1209–1213. https://doi.org/10.3109/09638288.2014.961654
Scott DL, Wolfe F, Huizinga TW (2010) Rheumatoid arthritis. Lancet 376(9746):1094–1108. https://doi.org/10.1016/s0140-6736(10)60826-4
Aviña-Zubieta JA, Choi HK, Sadatsafavi M, Etminan M, Esdaile JM, Lacaille D (2008) Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies. Arthritis Rheum 59(12):1690–1697. https://doi.org/10.1002/art.24092
Kwaśny-Krochin B, Głuszko P, Undas A (2012) Plasma asymmetric dimethylarginine in active rheumatoid arthritis: links with oxidative stress and inflammation. Pol Arch Med Wewn 122(6):270–276. https://doi.org/10.20452/pamw.1277
Baecklund E, Iliadou A, Askling J, Ekbom A, Backlin C, Granath F et al (2006) Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis. Arthritis Rheum 54(3):692–701. https://doi.org/10.1002/art.21675
Alvarez-Lafuente R, Fernández-Gutiérrez B, de Miguel S, Jover JA, Rollin R, Loza E et al (2005) Potential relationship between herpes viruses and rheumatoid arthritis: analysis with quantitative real time polymerase chain reaction. Ann Rheum Dis 64(9):1357–1359. https://doi.org/10.1136/ard.2004.033514
Gatenby P, Lucas R, Swaminathan A (2013) Vitamin D deficiency and risk for rheumatic diseases: an update. Curr Opin Rheumatol 25(2):184–191. https://doi.org/10.1097/BOR.0b013e32835cfc16
El-barbary AM, Khalek MAA, Elsalawy AM, Hazaa SM (2011) Assessment of lipid peroxidation and antioxidant status in rheumatoid arthritis and osteoarthritis patients. Egypt Rheumatol 33(4):179–185
Hitchon CA, El-Gabalawy HS (2004) Oxidation in rheumatoid arthritis. Arthritis Res Ther 6(6):265–278. https://doi.org/10.1186/ar1447
Gambhir JK, Lali P (1999) Blood selenium levels in healthy Indian subjects and patients with rheumatoid arthritis. Clin Biochem 32(8):665–666. https://doi.org/10.1016/s0009-9120(99)00061-2
Borglund M, Akesson A, Akesson B (1988) Distribution of selenium and glutathione peroxidase in plasma compared in healthy subjects and rheumatoid arthritis patients. Scand J Clin Lab Invest 48(1):27–32. https://doi.org/10.3109/00365518809085390
O’Dell JR, Lemley-Gillespie S, Palmer WR, Weaver AL, Moore GF, Klassen LW (1991) Serum selenium concentrations in rheumatoid arthritis. Ann Rheum Dis 50(6):376–378. https://doi.org/10.1136/ard.50.6.376
Tarp U, Overvad K, Hansen JC, Thorling EB (1985) Low selenium level in severe rheumatoid arthritis. Scand J Rheumatol 14(2):97–101. https://doi.org/10.3109/03009748509165490
Qamar N, John P, Bhatti A (2020) Toxicological and anti-rheumatic potential of trachyspermum ammi derived biogenic selenium nanoparticles in arthritic balb/c mice. Int J Nanomedicine 15:3497–3509. https://doi.org/10.2147/ijn.S243718
Vieira AT, Silveira KD, Arruda MC, Fagundes CT, Gonçalves JL, Silva TA et al (2012) Treatment with Selemax®, a selenium-enriched yeast, ameliorates experimental arthritis in rats and mice. Br J Nutr 108(10):1829–1838. https://doi.org/10.1017/s0007114512000013
Tarp U, Overvad K, Thorling EB, Graudal H, Hansen JC (1985) Selenium treatment in rheumatoid arthritis. Scand J Rheumatol 14(4):364–368. https://doi.org/10.3109/03009748509102039
Peretz A, Neve J, Duchateau J, Famaey JP (1992) Adjuvant treatment of recent onset rheumatoid arthritis by selenium supplementation: preliminary observations. Br J Rheumatol 31(4):281–282. https://doi.org/10.1093/rheumatology/31.4.281
Peretz A, Siderova V, Nève J (2001) Selenium supplementation in rheumatoid arthritis investigated in a double blind, placebo-controlled trial. Scand J Rheumatol 30(4):208–212. https://doi.org/10.1080/030097401316909549
Knyazeva AK, Komarova EB, Kuvichko NN (2016) Influence of selenium on clinical and laboratory parameters in patients with rheumatoid arthritis and subclinical hypothyroid dysfunction. Russian Open Medical Journal 5(4):e406. https://doi.org/10.15275/rusomj.2016.0406
Sun J, Zhang X, Broderick M, Fein H (2003) Measurement of nitric oxide production in biological systems by using griess reaction assay. Sensors 3(8):276–284
Benzie IF, Strain JJ (1999) Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods Enzymol 299:15–27. https://doi.org/10.1016/s0076-6879(99)99005-5
Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882–888
Dijkshoorn B, Raadsen R, Nurmohamed MT (2022) Cardiovascular disease risk in rheumatoid arthritis Anno 2022. J Clin Med 11(10). https://doi.org/10.3390/jcm11102704
Pope JE, Choy EH (2021) C-reactive protein and implications in rheumatoid arthritis and associated comorbidities. Semin Arthritis Rheum 51(1):219–229. https://doi.org/10.1016/j.semarthrit.2020.11.005
Shen R, Ren X, Jing R, Shen X, Chen J, Ju S et al (2015) Rheumatoid factor, anti-cyclic citrullinated peptide antibody, C-reactive protein, and erythrocyte sedimentation rate for the clinical diagnosis of rheumatoid arthritis. Lab Med 46(3):226–229. https://doi.org/10.1309/lmzytso5rhihv93t
Li LX, Chu JH, Chen XW, Gao PC, Wang ZY, Liu C et al (2022) Selenium ameliorates mercuric chloride-induced brain damage through activating BDNF/TrKB/PI3K/AKT and inhibiting NF-κB signaling pathways. J Inorg Biochem 229:111716. https://doi.org/10.1016/j.jinorgbio.2022.111716
Ruscitti P, Ursini F, Cipriani P, Ciccia F, Liakouli V, Carubbi F et al (2017) Prevalence of type 2 diabetes and impaired fasting glucose in patients affected by rheumatoid arthritis: Results from a cross-sectional study. Medicine (Baltimore) 96(34):e7896. https://doi.org/10.1097/md.0000000000007896
Li J, Chen Y, Liu Q, Tian Z, Zhang Y (2022) Mechanistic and therapeutic links between rheumatoid arthritis and diabetes mellitus. Clin Exp Med. https://doi.org/10.1007/s10238-022-00816-1
Radhakutty A, Mangelsdorf BL, Drake SM, Samocha-Bonet D, Jenkins AB, Heilbronn LK et al (2016) Effect of acute and chronic glucocorticoid therapy on insulin sensitivity and postprandial vascular function. Clin Endocrinol (Oxf) 84(4):501–508. https://doi.org/10.1111/cen.12966
Zhao J, Zou H, Huo Y, Wei X, Li Y (2022) Emerging roles of selenium on metabolism and type 2 diabetes. Front Nutr 9:1027629. https://doi.org/10.3389/fnut.2022.1027629
Faghihi T, Radfar M, Barmal M, Amini P, Qorbani M, Abdollahi M et al (2014) A randomized, placebo-controlled trial of selenium supplementation in patients with type 2 diabetes: effects on glucose homeostasis, oxidative stress, and lipid profile. Am J Ther 21(6):491–495. https://doi.org/10.1097/MJT.0b013e318269175f
Asemi Z, Jamilian M, Mesdaghinia E, Esmaillzadeh A (2015) Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: randomized, double-blind, placebo-controlled trial. Nutrition 31(10):1235–1242. https://doi.org/10.1016/j.nut.2015.04.014
Mahdavi Gorabi A, Hasani M, Djalalinia S, Zarei M, Ejtahed H, Abdar ME et al (2019) Effect of selenium supplementation on glycemic indices: a meta-analysis of randomized controlled trials. J Diabetes Metab Disord 18(2):349–362. https://doi.org/10.1007/s40200-019-00419-w
Tabrizi R, Akbari M, Moosazadeh M, Lankarani KB, Heydari ST, Kolahdooz F et al (2017) The effects of selenium supplementation on glucose metabolism and lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. Horm Metab Res 49(11):826–830. https://doi.org/10.1055/s-0043-119544
Garg N, Syngle A, Krishan P (2017) Nitric oxide: link between inflammation and endothelial dysfunction in rheumatoid arthritis. Int J Angiol 26(3):165–169. https://doi.org/10.1055/s-0036-1597577
Li H, Wan A (2013) Apoptosis of rheumatoid arthritis fibroblast-like synoviocytes: possible roles of nitric oxide and the thioredoxin 1. Mediators Inflamm 2013:953462. https://doi.org/10.1155/2013/953462
Dey P, Panga V, Raghunathan S (2016) A cytokine signalling network for the regulation of inducible nitric oxide synthase expression in rheumatoid arthritis. PLoS One 11(9):e0161306. https://doi.org/10.1371/journal.pone.0161306
Liu Y, Ma L, Zhou H, Zhu X, Yu Q, Chen X et al (2018) Polypeptide nano-Se targeting inflammation and theranostic rheumatoid arthritis by anti-angiogenic and NO activating AMPKα signaling pathway. J Mater Chem B 6(21):3497–3514. https://doi.org/10.1039/c8tb00080h
Djalalinia S, Hasani M, Asayesh H, Ejtahed HS, Malmir H, Kasaeian A et al (2021) The effects of dietary selenium supplementation on inflammatory markers among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. J Diabetes Metab Disord 20(1):1051–1062. https://doi.org/10.1007/s40200-021-00821-3
Wang X, Fan D, Cao X, Ye Q, Wang Q, Zhang M et al (2022) The role of reactive oxygen species in the rheumatoid arthritis-associated synovial microenvironment. antioxidants (Basel) 11(6). https://doi.org/10.3390/antiox11061153
Hasani M, Djalalinia S, Khazdooz M, Asayesh H, Zarei M, Gorabi AM et al (2019) Effect of selenium supplementation on antioxidant markers: a systematic review and meta-analysis of randomized controlled trials. Hormones (Athens) 18(4):451–462. https://doi.org/10.1007/s42000-019-00143-3
MacFarquhar JK, Broussard DL, Melstrom P, Hutchinson R, Wolkin A, Martin C et al (2010) Acute selenium toxicity associated with a dietary supplement. Arch Intern Med 170(3):256–261. https://doi.org/10.1001/archinternmed.2009.495
Mahmoud AH, AbdElMonem HA, Abbas MM (2022) The role of selenium and zinc oxide nanoparticles on mitigating side effects of obesity in rats. Braz J Biol 84:e264004. https://doi.org/10.1590/1519-6984.264004
Ibrahim SAZ, Kerkadi A, Agouni A (2019) Selenium and health: an update on the situation in the Middle East and North Africa. Nutrients 11(7). https://doi.org/10.3390/nu11071457
Turrubiates-Hernández FJ, Márquez-Sandoval YF, González-Estevez G, Reyes-Castillo Z, Muñoz-Valle JF (2020) The relevance of selenium status in rheumatoid arthritis. nutrients 12(10). https://doi.org/10.3390/nu12103007