Effects of Covid-19 on male reproductive system

Matheus Ferreira Gröner1, Renata Cristina de Carvalho1, Jacqueline Camillo1, Paulo Roberto Abrão Ferreira2, Renato Fraietta1
1Departamento de Cirurgia, Disciplina de Urologia, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, SP, Brasil
2Departamento de Medicina, Disciplina de Infectologia, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, SP, Brasil

Tóm tắt

Từ khóa


Tài liệu tham khảo

2020, Coronavirus disease (COVID-19) pandemic [Internet], World Health Organization

2020, The species Severe acute respiratory syndrome-related coronavirus: classifying 2019nCoV and naming it SARS-CoV-2. Version 2, Nat Microbiol, 5, 536, 10.1038/s41564-020-0695-z

2020, Entenda a diferença entre Coronavírus, Covid-19 e Novo Coronavírus. Os primeiros casos desse agente foram registrados na cidade de Wuhan, na China, Governo do Brasil

2020, CDC COVID Data Tracker. Coronavirus Disease 2019 (COVID-19), CDC Center For Disease Control And Prevention

Chen Y, 2020, Structure analysis of the receptor binding of 2019-nCoV, Biochem Biophys Res Commun, 525, 135, 10.1016/j.bbrc.2020.02.071

Guo YR, 2020, The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status, Mil Med Res, 7, 11

Corman VM, 2020, Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR, Euro Surveill, 25, 2000045, 10.2807/1560-7917.ES.2020.25.3.2000045

Guan WJ, 2020, Clinical Characteristics of Coronavirus Disease 2019 in China, N Engl J Med, 382, 1708, 10.1056/NEJMoa2002032

Xia J, 2020, Evaluation of coronavirus in tears and conjunctival secretions of patients with SARSCoV-2 infection, J Med Virol, 92, 589, 10.1002/jmv.25725

Chen L, 2020, Detection of 2019-nCoV in Saliva and Characterization of Oral Symptoms in COVID-19 Patients, SSRN

Zea-Mazo JW, 2010, Virus de transmisión sexual: relación semen y virus [Virus of sexual transmission: semen and virus relationship], Actas Urol Esp, 34, 845, 10.1016/j.acuro.2010.07.002

Gornet ME, 2016, Zika Virus in Semen: What We Know and What We Need to Know, Semin Reprod Med, 34, 285, 10.1055/s-0036-1592312

Zafer M, 2016, Effectiveness of semen washing to prevent human immunodeficiency virus (HIV) transmission and assist pregnancy in HIV-discordant couples: a systematic review and meta-analysis, Fertil Steril, 105, 645, 10.1016/j.fertnstert.2015.11.028

Ternavasio-de la Vega HG, 2010, Mumps orchitis in the post-vaccine era (1967-2009): a single-center series of 67 patients and review of clinical outcome and trends, Medicine (Baltimore), 89, 96, 10.1097/MD.0b013e3181d63191

Garolla A, 2013, Sperm viral infection and male infertility: focus on HBV, HCV, HIV HPV, HSV, HCMV, and AAV, J Reprod Immunol, 100, 20, 10.1016/j.jri.2013.03.004

Xu J, 2006, Orchitis: a complication of severe acute respiratory syndrome (SARS), Biol Reprod, 74, 410, 10.1095/biolreprod.105.044776

Gu J, 2005, Multiple organ infection and the pathogenesis of SARS, J Exp Med, 202, 415, 10.1084/jem.20050828

Zhao JM, 2003, [Clinical pathology and pathogenesis of severe acute respiratory syndrome], Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, 17, 217

Millet JK, 2012, Ezrin interacts with the SARS coronavirus Spike protein and restrains infection at the entry stage, PLoS One, 7, 10.1371/journal.pone.0049566

Song W, 2018, Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2, PLoS Pathog, 14, 10.1371/journal.ppat.1007236

Lu R, 2020, Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding, Lancet, 395, 565, 10.1016/S0140-6736(20)30251-8

Douglas GC, 2004, The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis, Endocrinology, 145, 4703, 10.1210/en.2004-0443

McDavid A, 2013, Data exploration, quality control and testing in single-cell qPCR-based gene expression experiments, Bioinformatics, 29, 461, 10.1093/bioinformatics/bts714

Fan C, 2020, ACE2 expression in kidney and testis may cause kidney and testis damage after 2019nCoV infection, MedRxiv

Wang Z, 2020, scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells, Cells, 9, 920, 10.3390/cells9040920

Shen Q, 2020, The ACE2 Expression in Sertoli Cells and Germ Cells May Cause Male Reproductive Disorder After Sars-cov-2 Infection, OSF Preprints

Zhang J, 2020, Bioinformatic Analysis Reveals That the Reproductive System is Potentially at Risk from SARS-CoV-2, Preprints

Hoffmann M, 2020, SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor, Cell, 181, 271, 10.1016/j.cell.2020.02.052

Pan F, 2020, No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019, Fertil Steril, 113, 1135, 10.1016/j.fertnstert.2020.04.024

Stanley KE, 2020, Coronavirus disease-19 and fertility: viral host entry protein expression in male and female reproductive tissues, Fertil Steril, 114, 33, 10.1016/j.fertnstert.2020.05.001

Sungnak W, 2020, SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes, Nat Med, 26, 681, 10.1038/s41591-020-0868-6

Qi J, 2020, The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID-19 infection, BioRxiv

Goyal P, 2020, Clinical Characteristics of Covid-19 in New York City, N Engl J Med, 382, 2372, 10.1056/NEJMc2010419

Bangalore S, 2020, ST-Segment Elevation in Patients with Covid-19 -A Case Series, N Engl J Med, 382, 2478, 10.1056/NEJMc2009020

Rabb H, 2020, Kidney diseases in the time of COVID-19: major challenges to patient care, J Clin Invest, 130, 2749, 10.1172/JCI138871

Ke Wang, 2020, SARS-CoV-2 invades host cells via a novel route: CD147-spike protein, BioRxiv

Ou X, 2020, Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV Version 2, Nat Commun, 11, 1620, 10.1038/s41467-020-15562-9

Song C, Absence of 2019 Novel Coronavirus in Semen and Testes of COVID-19 Patients, Biol Reprod, 103, 4, 10.1093/biolre/ioaa050

Li D, 2020, Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019, JAMA Netw Open, 3

Zou L, 2020, SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients, N Engl J Med, 382, 1177, 10.1056/NEJMc2001737

To KK, 2020, Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study, Lancet Infect Dis, 20, 565, 10.1016/S1473-3099(20)30196-1

Weihe quan, 2020, No SARS-CoV-2 in expressed prostatic secretion of patients with coronavirus disease 2019: a descriptive multicentre study in China, medRxiv

Ling Ma, 2020, Effect of SARS-CoV-2 infection upon male gonadal function: A single center-based study, MedRxiv

Carlsen E, 2003, History of febrile illness and variation in semen quality, Hum Reprod, 18, 2089, 10.1093/humrep/deg412

Jung A, 2007, Influence of genital heat stress on semen quality in humans, Andrologia, 39, 203, 10.1111/j.1439-0272.2007.00794.x

Zhang S, 2015, Relation between the testicular sperm assay and sex hormone level in patients with azoospermia induced by mumps, Int J Clin Exp Med, 8, 21669