Effects of Δ-9-tetrahydrocannabinol on the slope of auditory generalization gradients in rats
Tóm tắt
Groups of rats were given 2, 4, or 6 mg/kg Δ-9-tetrahydrocannabinol (Δ-9-THC) during shuttle-avoidance training and auditory generalization testing in extinction. Although the drug had no discernible effect on acquisition performance, there was a dose-dependent influence on the slopes of the generalization gradients. It was concluded that Δ-9-THC can affect the extent of auditory generalization during extinction, even when there is no apparent effect on acquisition performance. The outcomes of the study were interpreted in terms of their relevance to the drug’s presumed effects on audition and various motivational processes.
Tài liệu tham khảo
Bicher, H. I., & Mechoulam, R. Pharmacological effects of two active constituents of marihuana. Archives Internationales de Pharmacodynamie et de Therapie, 1968, 172, 24–31.
Brennan, J. F., & Riccio, D. C. Stimulus control of avoidance in rats following differential or nondifferential Pavlovian training along dimensions of the conditioned stimulus. Journal of Comparative and Physiological Psychology, 1973, 85, 313–323.
Caldwell, D. F., Myers, S. A., Domino, E. F., & Merriam, P. E. Auditory and visual threshold effects of marihuana in man. Perceptual and Motor Skills, 1969, 29, 755–759.
de Souza, M. R. C., Karniol, I. G., & Ventura, D. G. Human tonal preferences as a function of frequency under delta-8-tetrahydrocannabinol. Pharmacology, Biochemistry and Behavior, 1974, 2, 607–611.
Elsmore, T. F. Effects of delta-9-tetrahydrocannabinol on temporal and auditory discrimination performance of monkeys. Psychopharmacologia, 1972, 26, 62–72.
Fenimore, D. C., & Loy, P. R. Injectible dispersion of Δ9-tetrahydrocannabinol in saline using polyvinylpyrrolidone. Journal of Pharmacy and Pharmacology, 1971, 23, 310.
Henriksson, B. G., & JäRBE, T. The effect of two tetrahydrocannabinols (Δ9-THC and Δ8-THC) on conditioned avoidance learning in rats and its transfer to normal state conditions. Psychopharmacologia, 1971, 22, 23–30.
Jaffe, P. G., & Baum, M. Increased resistance-to-extinction of an avoidance response in rats following the administration of hashish resin. Psychopharmacologia, 1971, 20, 97–102.
Key, B. J. The effect of drugs on discrimination and sensory generalization of auditory stimuli in cats. Psychopharmacologia, 1961, 2, 352–363.
Lyons, J., Ferraro, D. P., Lyons, J. E., Sullivan, J. G. & Downey, D. Effects of delta-9-tetrahydrocannabinol on stimulus control. Bulletin of the Psychonomic Society, 1973, 2, 302–304.
Rohrbaugh, M., Brennan, J. F., & Riccio, D. C. Control of two-way shuttle avoidance in rats by auditory frequency and intensity. Journal of Comparative and Physiological Psychology, 1971, 75, 324–330.
Tart, C. T. On being stoned. A psychological study of marihuana intoxication. Palo Alto, California: Science and Behavior Books. 1971.