Effective delivery of sonication energy to fast settling and agglomerating nanomaterial suspensions for cellular studies: Implications for stability, particle kinetics, dosimetry and toxicity

Beltran-Huarac, 2017 Cohen, 2013, Interactions of engineered nanomaterials in physiological media and implications for in vitro dosimetry, Nanotoxicology, 7, 417, 10.3109/17435390.2012.666576 Cohen, 2015, A critical review of in vitro dosimetry for engineered nanomaterials, Nanomedicine, 10, 3015, 10.2217/nnm.15.129 Cohen, 2014, An integrated approach for the in vitro dosimetry of engineered nanomaterials, Part. Fibre Toxicol., 11, 20, 10.1186/1743-8977-11-20 DeLoid, 2014, Estimating the effective density of engineered nanomaterials for in vitro dosimetry, Nat. Commun., 5, 10.1038/ncomms4514 DeLoid, 2017, Preparation, characterization, and in vitro dosimetry of dispersed, engineered nanomaterials, Nat. Protoc., 12, 355, 10.1038/nprot.2016.172 DeLoid, 2015, Advanced computational modeling for in vitro nanomaterial dosimetry, Part. Fibre Toxicol., 12, 10.1186/s12989-015-0109-1 Demokritou, 2010, Development and characterization of a Versatile Engineered Nanomaterial Generation System (VENGES) suitable for toxicological studies, Inhal. Toxicol., 22, 2107, 10.3109/08958378.2010.499385 Derjaguin, 1941, Theory of the stability of strongly charged lyophobic sols and of the adhesion of strongly charged particlces in solutions of electrolytes, Acta Physicochim., 14, 30 Eleftheriadou, 2017, Nanotechnology to the rescue: using nano-enabled approaches in microbiological food safety and quality, Curr. Opin. Biotechnol., 44, 87, 10.1016/j.copbio.2016.11.012 Final Report Summary Grassian, 2016, NanoEHS – defining fundamental science needs: no easy feat when the simple itself is complex, Environ. Sci.: Nano, 3, 15 Halamoda-Kenzaoui, 2015, Dispersion behaviour of silica nanoparticles in biological media and its influence on cellular uptake, PLoS One, 10, 10.1371/journal.pone.0141593 Halamoda-Kenzaoui, 2017, The agglomeration state of nanoparticles can influence the mechanism of their cellular internalisation, J. Nanobiotechnol., 15, 48, 10.1186/s12951-017-0281-6 Jensen Jiang, 2009, Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies, J. Nanopart. Res., 11, 77, 10.1007/s11051-008-9446-4 Krewski, 2010, Toxicity testing in the 21st century: a vision and a strategy, J. Toxicol. Environ. Health B Crit. Rev., 13, 51, 10.1080/10937404.2010.483176 Lai, 2011, Toward toxicity testing of nanomaterials in the 21st century: a paradigm for moving forward, Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 4, 1, 10.1002/wnan.162 Lorimer, 1995, Effect of ultrasound on the degradation of aqueous native dextran, Ultrason. Sonochem., 2, 55, 10.1016/1350-4177(94)00013-I Magdolenova, 2012, Impact of agglomeration and different dispersions on titanium dioxide nanoparticles on the human related in vitro cytotoxicity and genotoxicity, J. Environ. Monit., 14, 455, 10.1039/c2em10746e Mandzy, 2005, Breakage of TiO2 agglomerates in electrostatically stabilized aqueous dispersions, Powder Technol., 160, 121, 10.1016/j.powtec.2005.08.020 Mason, 2003 McClements, 2016, The role of the food matrix and gastrointestinal tract in the assessment of biological properties of ingested engineered nanomaterials (ENMs): state of the science and knowledge gaps, NanoImpact, 3, 47, 10.1016/j.impact.2016.10.002 McClements, 2017, Physicochemical and colloidal aspects of food matrix effects on gastrointestinal fate of ingested inorganic nanoparticles, Adv. Colloid Interf. Sci., 246, 165, 10.1016/j.cis.2017.05.010 Murdock, 2008, Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique, Toxicol. Sci., 101, 239, 10.1093/toxsci/kfm240 Naddeo, 2007, Behaviour of natural organic matter during ultrasonic irradiation, Desalination, 210, 175, 10.1016/j.desal.2006.05.042 National Science and Technology Council Committee on Technology Subcommittee on Nanoscale Science, Engineering, and Technology Oecd Pal, 2015, Implications of in vitro dosimetry on toxicological ranking of low aspect ratio engineered nanomaterials, Nanotoxicology, 9, 871, 10.3109/17435390.2014.986670 Pirela, 2016, Effects of intratracheally instilled laser printer-emitted engineered nanoparticles in a mouse model: a case study of toxicological implications from nanomaterials released during use, NanoImpact, 1, 1, 10.1016/j.impact.2015.12.001 Pirela, 2017, Nanoparticle exposures from nano-enabled toner-based printing equipment and human health: state of science and future research needs, Crit. Rev. Toxicol., 47, 678, 10.1080/10408444.2017.1318354 Pyrgiotakis, 2014, Real-time nanoparticle-cell interactions in physiological media by atomic force microscopy, ACS Sustain. Chem. Eng., 2, 1681, 10.1021/sc500152g Pyrgiotakis, 2013, Nanoparticle-nanoparticle interactions in biological media by atomic force microscopy, Langmuir, 29, 11385, 10.1021/la4019585 Pyrgiotakis, 2014, Mycobacteria inactivation using Engineered Water Nanostructures (EWNS), Nanomedicine, 10, 1175, 10.1016/j.nano.2014.02.016 Pyrgiotakis, 2016, Optimization of a nanotechnology based antimicrobial platform for food safety applications using Engineered Water Nanostructures (EWNS), Sci. Rep., 6, 10.1038/srep21073 Radziuk, 2010, Ultrasound-assisted fusion of preformed gold nanoparticles, J. Phys. Chem. C, 114, 1835, 10.1021/jp910374s Roco, 2011 Rodrigues, 2017, Nanotechnology for sustainable food production: promising opportunities and scientific challenges, Environ. Sci.: Nano, 4, 767 Schulze, 2008, Not ready to use - overcoming pitfalls when dispersing nanoparticles in physiological media, Nanotoxicology, 2, 51, 10.1080/17435390802018378 Servin, 2016, Nanotechnology in agriculture: next steps for understanding engineered nanoparticle exposure risk, NanoImpact, 1, 9, 10.1016/j.impact.2015.12.002 Singh, 2017, Nanofiller presence enhances polycyclic aromatic hydrocarbon (PAH) profile on nanoparticles released during thermal decomposition of nanoenabled thermoplastics: potential environmental health implications, Environ. Sci. Technol., 51, 5222, 10.1021/acs.est.6b06448 Sotiriou, 2014, Engineering safer-by-design, transparent, silica-coated ZnO nanorods with reduced DNA damage potential, Environ. Sci.: Nano, 1, 144 Sotiriou, 2012, A novel platform for pulmonary and cardiovascular toxicological characterization of inhaled engineered nanomaterials, Nanotoxicology, 6, 680, 10.3109/17435390.2011.604439 Taurozzi, 2011, Ultrasonic dispersion of nanoparticles for environmental, health and safety assessment - issues and recommendations, Nanotoxicology, 5, 711, 10.3109/17435390.2010.528846 Taurozzi, 2013, A standardised approach for the dispersion of titanium dioxide nanoparticles in biological media, Nanotoxicology, 7, 389, 10.3109/17435390.2012.665506 Tsuda, 2016, The role of natural processes and surface energy of inhaled eningeered nanomaterials on aggregation and corona formation, NanoImpact, 2, 38, 10.1016/j.impact.2016.06.002 Uskokivic, 2012, Dynamic light scattering based microelectrophoresis: main prospects and limitaionts, J. Dispers. Sci. Technol., 33, 1762, 10.1080/01932691.2011.625523 Watson, 2014, High-throughput screening platform for engineered nanoparticle-mediated genotoxicity using CometChip technology, ACS Nano, 8, 2118, 10.1021/nn404871p Watson-Wright, 2017, Toxicological implications of released particulate matter during thermal decomposition of nano-enabled thermoplastics, NanoImpact, 5, 29, 10.1016/j.impact.2016.12.003 Wu, 2014, Dispersion method for safety research on manufactured nanomaterials, Ind. Health, 52, 54, 10.2486/indhealth.2012-0218 Xia, 2013, Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the niehs nano go consortium, Environ. Health Perspect., 121, 683, 10.1289/ehp.1306561 Yohan, 2014, Applications of nanoparticles in nanomedicine, J. Biomed. Nanotechnol., 10, 2371, 10.1166/jbn.2014.2015