Effect of truncal vagotomy on neurotensin-like immunoreactivity release in dogs
Tóm tắt
To elucidate the relationship between the vagus nerve and circulating neurotensin release, mongrel dogs were given an intraduodenal infusion of a 50 ml water solution containing 10 g glucose (n = 4) or 5 g soybean oil (n = 7) over a period of 4 min before and after truncal vagotomy with pyloroplasty. In the prevagotomized animals only a slight increase of neurotensin-like immunoreactivity (NTLI) was observed following glucose infusion, while NTLI in response to fat infusion was significantly increased. After vagotomy, NTLI release following fat infusion was significantly decreased when compared to untreated control animals, suggesting that vagotomy causes a major alteration in circulating NTLI release and that the vagus nerve may play a definite role in fat-induced NTLI release.
Tài liệu tham khảo
Carraway R, et al: Characterization of radioimmunoassayable neutrotensin in the rat; its differential distribution in the central nervous system, small intestine and stomach. J Biol Chem 251: 7045, 1976
Frigerio B, et al: Histochemical and ultrastructural identification on neurotensin cells in the dog ileum. Histochemistry 54: 123, 1977
Helmstaedter V, et al: Localization of neurotensin immunoreactive cells in the small intestine of man and various mammals. Histochemistry 53: 35, 1977
Orci L, et al: Evidence for immunoreactive neurotensin in dog intestinal mucosa. Life Sci 19: 559, 1976
Rosell S, et al: Cardiovascular and metabolic actions of neurotensin and (Gln4)-neurotensin. Acta Physiol Scand 98:484, 1976
Nagai K, et al: Hyperglycemia and hyperglucagonemia following neurotensin administration. Life Sci 19: 273, 1976
Anderson S, et al: Inhibition of gastric acid secretion in dogs by neurotensin. Life Sci 19: 367, 1976
Anderson S, et al: Inhibition of gastric and intestinal motor activity in dogs by (Gln4)-neurotensin. Aeta Physiol Scand 100: 231, 1977
Mashford ML, et al: Release of neurotensin-like immunoreactivity (NTLI) from the gut in anesthetized dogs. Acta Physiol Scand 104: 375, 1978
Rosell S, et al: The effect of ingestion of amino acids, glucose and fat on circulating neurotensin-like immunoreactivity (NTLI) in man. Acta Physiol Scand 107:263, 1979
Demol P, et al: Neural influence of neurotensin (NT) release by intraluminal nutrients. Gastroenterology 80: 1134, 1981
Fletcher DR, et al: Cholinergic inhibition of meal stimulated plasma neurotensin like immunoreactivity in man. Life Sci 33: 863, 1983
Yamagishi T, et al: Control of gastric emptying: interaction of the vagus and pyloric antrum. Ann Surg187: 91, 1978
Go VLW, et al: Role of nutrients in the gastrointestinal release of immunoreactive neurotensin. Peptides 2, Suppl: 267, 1981
Ito S, et al: Plasma radioimmunoassayable neurotensin responses to the administration of various nutrients. Tohoku J exp Med 136: 109, 1982
Debas HT, et al: Effect of extragastric and truncal vagotomy on pancreatic secretion in the dog. Am J Physiol 228: 1172, 1975
Fried GM, et al: Correlation of release and actions of cholecystokinin in dogs before and after vagotomy. Surgery 93: 786, 1983
Fletcher DM, et al: Changes in canine bile-flow and composition after vagotomy. Brit J Surg 56: 103, 1969
Rökaeus Å, et al: The importance of bile and pancreatic juice for fat-induced release of neurotensin-like immunoreactivity (NTLI) from the small intestine of the rat. Acta Physiol Scand 119: 33, 1983
Wilkinson AR, et al: Effect of truncal, selective and highly selective vagotomy on gastric emptying and intestinal transit of a food-barium meal in man. Ann Surg 178:190, 1973
Lundgvist H, et al: Analysis of small bowel propulsion, ileo-caecal passage and serum gastrin after truncal vagotomy. Acta Chir Scand 141: 298, 1975
Nillson F: Effect of truncal vagotomy and pyloroplasty on gastric evacuation and small bowel propulsion in the rat. Acta Chir Scand 139: 731, 1973