Effect of tolvaptan on acute heart failure with hyponatremia – A randomized, double blind, controlled clinical trial

Gross, 2008, Treatment of hyponatremia, Inter Med, 47, 885, 10.2169/internalmedicine.47.0918 Filippatos, 2013, Hyponatremia in patients with heart failure, World J Cardiol, 5, 317, 10.4330/wjc.v5.i9.317 Verbalis, 2013, Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations, Am J Med, 126, S1, 10.1016/j.amjmed.2013.07.006 Amin, 2013, Healthcare resource burden associated with hyponatremia among patients hospitalized for heart failure in the US, J Med Econ, 16, 415, 10.3111/13696998.2013.766615 Felker, 2004, Risk stratification after hospitalization for decompensated heart failure, J Card Fail, 10, 460, 10.1016/j.cardfail.2004.02.011 Lee, 2003, Predicting mortality among patients hospitalized for heart failure: derivation and validation of a clinical model, JAMA, 290, 2581, 10.1001/jama.290.19.2581 Nielsen, 2002, Aquaporins in the kidney: from molecules to medicine, Physiol Rev, 82, 205, 10.1152/physrev.00024.2001 Imamura, 2014, Assessment of quality of life during long-term treatment of tolvaptan in refractory heart failure: design and rationale of the AQUA-TLV study, Int Heart J, 55, 264, 10.1536/ihj.13-326 Inomata, 2011, Phase III clinical pharmacology study of tolvaptan, Cardiovasc Drugs Ther Spons Int Soc Cardiovasc Pharmacother, 25, S57, 10.1007/s10557-011-6349-x Goldsmith, 2012, Hyponatremia and outcomes in patients with heart failure, Heart Br Card Soc, 98, 1761 Patra, 2014, Short term efficacy and safety of low dose tolvaptan in patients with acute decompensated heart failure with hyponatremia: a prospective observational pilot study from a single center in South India, Heart Views Off J Gulf Heart Assoc, 15, 1, 10.4103/1995-705X.132136 Matsuzaki, 2011, Efficacy and safety of tolvaptan in heart failure patients with volume overload despite the standard treatment with conventional diuretics: a phase III, randomized, double-blind, placebo-controlled study (QUEST study), Cardiovasc Drugs Ther Spons Int Soc Cardiovasc Pharmacother, 25, S33, 10.1007/s10557-011-6304-x Konstam, 2007, Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial, JAMA, 297, 1319, 10.1001/jama.297.12.1319 Matsuzaki, 2011, Effects of tolvaptan on volume overload in Japanese patients with heart failure: results of a phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group study, Cardiovasc Drugs Ther Spons Int Soc Cardiovasc Pharmacother, 25, S19, 10.1007/s10557-011-6303-y Gheorghiade, 2003, Vasopressin V2-receptor blockade with tolvaptan in patients with chronic heart failure: results from a double-blind, randomized trial, Circulation, 107, 2690, 10.1161/01.CIR.0000070422.41439.04 Kinugawa, 2014, Efficacy and safety of tolvaptan in heart failure patients with volume overload – an interim result of post-marketing surveillance in Japan, Circ J, 78, 844, 10.1253/circj.CJ-66-0093 Kim, 2011, Pharmacokinetics, pharmacodynamics and safety of tolvaptan, a novel, oral, selective nonpeptide AVP V2-receptor antagonist: results of single- and multiple-dose studies in healthy Japanese male volunteers, Cardiovasc Drugs Ther Spons Int Soc Cardiovasc Pharmacother, 25, S5, 10.1007/s10557-011-6299-3 Pang, 2011, Effects of tolvaptan on physician-assessed symptoms and signs in patients hospitalized with acute heart failure syndromes: analysis from the efficacy of vasopressin antagonism in heart failure outcome study with tolvaptan (EVEREST) trials, Am Heart J, 161, 1067, 10.1016/j.ahj.2011.02.027 Hauptman, 2013, Clinical course of patients with hyponatremia and decompensated systolic heart failure and the effect of vasopressin receptor antagonism with tolvaptan, J Card Fail, 19, 390, 10.1016/j.cardfail.2013.04.001 Udelson, 2011, A multicenter, randomized, double-blind, placebo-controlled study of tolvaptan monotherapy compared to furosemide and the combination of tolvaptan and furosemide in patients with heart failure and systolic dysfunction, J Card Fail, 17, 973, 10.1016/j.cardfail.2011.08.005