Effect of the peptide Semaks on UV-induced damaging of the plasma membranes of peritoneal macrophages in mice
Tóm tắt
We studied the effect of nootropic peptide Semaks and its inactive analog on the efficiency of UV-induced damaging of the peritoneal macrophage plasma membrane. The increase of the time after the UV-irradiation (with doses 5 and 6 J/cm2) from 15 to 60 min led to a substantial increase in the number of damaged cells. The UV-irradiation effect has been subjected to a substantial decrease with the adding of Semaks to the incubation medium immediately after irradiation.
Tài liệu tham khảo
Astashkin, E.I., Bespalova, Yu.B., Grivennikov, I.A., Smirnov, O.N., Glezer, M.G., and Grachev, S.V., The Study of the Semaks Effect on Ca2+ Responces of Human Neutrophyls, Dokl. Akad. Nauk, 2000, vol. 374, no. 3, pp. 401–403.
Dankberg, F. and Persidsky, M.D., A Test of Granulocyte Membrane Integrity and Phagocytic Function, Cryobiology, 1976, vol. 13, pp. 430–432.
Grivennikov, I.A., Dolotov, O.V., and Gol’dina, Yu.I., Factors of Peptide Nature Concerning with Proliferation, Differentiation and Viability Maintaining of Nervous Cells of Mammals, Mol. Biol., 1999, no. 1, pp. 120–126.
Gusev, V.I., Skvortsova, V.I., Myasoedov, N.F., Nezavibat’ko, V.N., Zhuravleva, E.Yu., and Vanichkin, A.V., The Efficacy of Semaks in the Acute Period of the Hemisphere Ischemic Insult (Clinic and Electrophysiological Study, Zhurn. Nevrol. Psikhiatr., 1997, vol. 33, no. 6, pp. 26–34.
Kaplan, A.Ya., Koshelev, V.B., Nezavibat’ko, V.N., and Ashmarin, I.P., The Neuropeptide Medical Preparation Semaks Increases the Resistance of the Organism to Hypoxia, Fiziol. Cheloveka, 1992, vol. 18, no. 5, pp. 104–107.
Mayanskii, A.N. and Mayanskii, D.N., Ocherki o neitrofile i makrofage (The Essays on the Neutrophils and Macrophages), Novosibirsk, 1989 [in Russian].
Myasoedov, N.F., Ashmarin, I.P., Kamenskii, A.A., Nezavibat’ko, N.V., Grivennikov, I.A., Andreeva, L.A., Kaplan, A.Ya., and Ryasina, T.V., Nootropnyi Analog AKTG: 4–10)—semaks, Zh. Vyssh. Nervn. Deyat. im. I.P. Pavlova, 1997, vol. 47, no. 2, pp. 420–430.
Pirutin, S.K., Turovetskii, V.B., Kudryashov, Yu.B., and Rubin, A.B., Injuring of the Macrophage Membranes under the Moderate Doses of the UV irradiation, Radiats. Biol.: Radioekol., 2002, vol. 42, no. 2, pp. 147–150.
Roshchupkin, D.I. and Murina, M.A., Photobiological Processes in Membranes under the Action of the UV-Irradiation on Cells, Tissues and Organs of the Animals, Biofizika, 1993, vol. 38, no. 6, pp. 1053–1068.
Safarova, E.R., Shram, S.I., Zolotarev, Yu.A., and Myasoedov, N.F., The Influence of the Peptide Semaks on Survival of the Rat Feochromocytomy with the Oxidation Stress, Byul. Eksperiment. Biol. Med, 2003, vol. 135, no. 3, pp. 309–313.
Vladimirov, Yu.A. and Archakov, A.I., Perekisnoe okislenie lipidov v biologicheskikh membranakh (Peroxide Oxidation of Lipids in the Biological Membranes), Moscow, 1972 [in Russian].