Effect of supplementation with leucine alone, with other nutrients or with physical exercise in older people with sarcopenia: a systematic review

Enrique Conde Maldonado1, Diego Marqués-Jiménez1,2, Patricia Casas-Agustench1,3, Anna Bach-Faig4,5
1Facultad de Ciencias de la Salud, Universitat Oberta de Catalunya (UOC), Barcelona, Spain
2Deportivo Alavés (SAD) (Academia), Vitoria-Gasteiz, Spain
3School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, UK
4Grupo de Investigación FoodLab (2017SGR 83), Facultad de Ciencias de la Salud, Universitat Oberta de Catalunya, Barcelona, Spain
5Vocalía de Alimentación y Nutrición, Colegio Oficial de Farmacéuticos de Barcelona, Barcelona, Spain

Tài liệu tham khảo

Cade, 2006, Metabolic and molecular aspects of sarcopenia, 529 Verdijk, 2015, Satellite cells in human skeletal muscle: plasticity, Front Physiol., 6, 283 Romanello, 2016, Mitochondrial quality control and muscle mass maintenance, Front Physiol., 6, 422, 10.3389/fphys.2015.00422 Bian, 2020, Association between sarcopenia and levels of growth hormone and insulin-like growth factor-1 in the elderly, BMC Musculoskelet Disord., 21, 1, 10.1186/s12891-020-03236-y Pomatto, 2017, The role of declining adaptive homeostasis in ageing, J Physiol., 595, 7275, 10.1113/JP275072 Rosenberg, 1997, Symposium: sarcopenia: diagnosis and mechanisms sarcopenia: origins and clinical relevance 1, J Nutr., 127, 990, 10.1093/jn/127.5.990S Cruz-Jentoft, 2010, Sarcopenia: European consensus on definition and diagnosis, Age Ageing., 39, 412, 10.1093/ageing/afq034 Cruz-Jentoft, 2019, Sarcopenia: Revised European consensus on definition and diagnosis, Age Ageing., 48, 16, 10.1093/ageing/afy169 Salvà, 2016, La prevalencia de sarcopenia en residencias de España: comparación de los resultados del estudio multicéntrico ELLI con otras poblaciones, Rev Esp Geriatr Gerontol., 51, 260, 10.1016/j.regg.2016.02.004 Mitchell, 2012, Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review, Front Physiol., 3, 260, 10.3389/fphys.2012.00260 Coelho-junior, 2020, Protein intake and frailty: a matter of quantity, quality, and timing, Nutrients., 12, 2915, 10.3390/nu12102915 McLean, 2014, Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: The Foundation for the National Institutes of Health (FNIH) sarcopenia project, J Gerontol - Ser A Biol Sci Med Sci., 69, 576, 10.1093/gerona/glu012 Burd, 2011, Enhanced amino acid sensitivity of myofibrillar protein synthesis persists for up to 24 h after resistance exercise in young men, J Nutr., 141, 568, 10.3945/jn.110.135038 Koopman, 2009, Aging, exercise, and muscle protein metabolism, J Appl Physiol., 106, 2040, 10.1152/japplphysiol.91551.2008 Phillips, 2016, Protein “requirements” beyond the RDA: implications for optimizing health, Appl Physiol Nutr Metab., 41, 565, 10.1139/apnm-2015-0550 Franzke, 2018, Dietary protein, muscle and physical function in the very old, Nutrients., 10, 935, 10.3390/nu10070935 Lonnie, 2018, Protein for life: review of optimal protein intake, sustainable dietary sources and the effect on appetite in ageing adults, Nutrients., 10, 360, 10.3390/nu10030360 Traylor, 2018, Perspective: protein requirements and optimal intakes in aging: are we ready to recommend more than the recommended daily allowance?, Adv Nutr., 9, 171, 10.1093/advances/nmy003 Deutz, 2012, Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN Expert Group, Clin Nutr., 100, 130 Hernández Triana, 2004, Recomendaciones nutricionales para el ser humano: actualización, Rev Cubana Invest Bioméd [Internet]., 23, 266 Rondanelli, 2016, Whey protein, amino acids, and Vitamin D supplementation with physical activity increases fat-free mass and strength, functionality, and quality of life and decreases inflammation in sarcopenic elderly, Am J Clin Nutr., 103, 830, 10.3945/ajcn.115.113357 Peña-Ordóñez, 2016, Evaluación de la ingesta proteica y la actividad física asociadas con la sarcopenia del adulto mayor, Rev Esp Nutr Humana Diet., 20, 16, 10.14306/renhyd.20.1.178 Martínez-arnau, 2019, Beneficial effects of leucine supplementation on criteria for sarcopenia: a systematic review, Nutrients., 11, 2504, 10.3390/nu11102504 Liberati, 2009, The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration, PLoS Med., 6, 10.1371/journal.pmed.1000100 Higgins, 2011, The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials, BMJ., 343, 10.1136/bmj.d5928 Verhoeven, 2009, Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men, Am J Clin Nutr., 89, 1468, 10.3945/ajcn.2008.26668 Leenders, 2011, Prolonged leucine supplementation does not augment muscle mass or affect glycemic control in elderly type 2 diabetic men, J Nutr., 141, 1070, 10.3945/jn.111.138495 Martínez-Arnau, 2020, Effects of leucine administration in sarcopenia: a randomized and placebo-controlled clinical trial, Nutrients., 12, 932, 10.3390/nu12040932 Jacob, 2019, Leucine supplementation does not alter insulin sensitivity in prefrail and frail older women following a resistance training protocol, J Nutr., 149, 959, 10.1093/jn/nxz038 Solerte, 2008, Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia, Am J Cardiol., 101, 69E, 10.1016/j.amjcard.2008.03.004 Ferrando, 2010, EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly, Clin Nutr [Internet]., 29, 18, 10.1016/j.clnu.2009.03.009 Bauer, 2015, Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial, J Am Med Dir Assoc [Internet]., 16, 740, 10.1016/j.jamda.2015.05.021 Abe, 2016, Medium-chain triglycerides in combination with leucine and vitamin D increase muscle strength and function in frail elderly adults in a randomized controlled trial, J Nutr., 146, 1017, 10.3945/jn.115.228965 Evans, 2017, Efficacy of a novel formulation of L-Carnitine, creatine, and leucine on lean body mass and functional muscle strength in healthy older adults: a randomized, double-blind placebo-controlled study, Nutr Metab [Internet]., 14, 7, 10.1186/s12986-016-0158-y Chanet, 2017, Supplementing breakfast with a vitamin D and leucine–enriched whey protein medical nutrition drink enhances postprandial muscle protein synthesis and muscle mass in healthy older men, J Nutr., 147, 2262, 10.3945/jn.117.252510 Hill, 2019, A vitamin D, calcium and leucine-enriched whey protein nutritional supplement improves measures of bone health in sarcopenic non-malnourished older adults: the PROVIDE study, Calcif Tissue Int [Internet]., 105, 383, 10.1007/s00223-019-00581-6 Kim, 2012, Effects of exercise and amino acid supplementation on body composition and physical function in community-dwelling elderly Japanese sarcopenic women: a randomized controlled trial, J Am Geriatr Soc., 60, 16, 10.1111/j.1532-5415.2011.03776.x van de Bool, 2017, A randomized clinical trial investigating the efficacy of targeted nutrition as adjunct to exercise training in COPD, J Cachexia Sarcopenia Muscle., 8, 748, 10.1002/jcsm.12219 Amasene, 2019, Effects of Leucine-enriched whey protein supplementation on physical function in post-hospitalized older adults participating in 12-weeks of resistance training program: a randomized controlled trial, Nutrients., 11, 2337, 10.3390/nu11102337 Randolph, 2020, Effect of essential amino acid supplementation and aerobic exercise on insulin sensitivity in healthy older adults: A randomized clinical trial, Clin Nutr., 39, 1371, 10.1016/j.clnu.2019.06.017 Kirk, 2019, Exercise and dietary-protein as a countermeasure to skeletal muscle weakness: Liverpool Hope University - Sarcopenia aging trial (LHU-SAT), Front Physiol., 10, 445, 10.3389/fphys.2019.00445 Yoshimura, 2019, Effects of a leucine-enriched amino acid supplement on muscle mass, muscle strength, and physical function in post-stroke patients with sarcopenia: a randomized controlled trial, Nutrition [Internet]., 58, 1, 10.1016/j.nut.2018.05.028 Kirk, 2020, Effects of exercise and whey protein on muscle mass, fat mass, myoelectrical muscle fatigue and health-related quality of life in older adults: a secondary analysis of the Liverpool Hope University—Sarcopenia Ageing Trial (LHU-SAT), Eur J Appl Physiol [Internet]., 120, 493, 10.1007/s00421-019-04293-5 Moriwaki, 2019, The effect of branched chain amino acids-enriched nutritional supplements on activities of daily living and muscle mass in inpatients with gait impairments: a randomized controlled trial, J Nutr Heal Aging., 23, 348, 10.1007/s12603-019-1172-3 Yamamoto, 2020, Effects of resistance training using elastic bands on muscle strength with or without a leucine supplement for 48 weeks in elderly patients with type 2 diabetes, Endocr J., 68, 291, 10.1507/endocrj.EJ20-0550 Kang, 2020, Leucine-enriched protein supplementation increases lean body mass in healthy Korean adults aged 50 years and older: a randomized, double-blind, placebo-controlled trial, Nutrients., 12, 1816, 10.3390/nu12061816 Rondanelli, 2020, Improving rehabilitation in sarcopenia: a randomized-controlled trial utilizing a muscle-targeted food for special medical purposes, J Cachexia Sarcopenia Muscle., 11, 1535, 10.1002/jcsm.12532 Muscaritoli, 2010, Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”, Clin Nutr., 29, 154, 10.1016/j.clnu.2009.12.004 Luiking, 2014, Postprandial muscle protein synthesis is higher after a high whey protein, leucine-enriched supplement than after a dairy-like product in healthy older people: a randomized controlled trial, Nutr J [Internet]., 13, 9, 10.1186/1475-2891-13-9 Holwerda, 2019, Dose-dependent increases in whole-body net protein balance and dietary protein-derived amino acid incorporation into myofibrillar protein during recovery from resistance exercise in older men, J Nutr., 149, 221, 10.1093/jn/nxy263 Churchward-Venne, 2020, Dose-response effects of dietary protein on muscle protein synthesis during recovery from endurance exercise in young men: a double-blind randomized trial, Am J Clin Nutr., 112, 303, 10.1093/ajcn/nqaa073