Effect of self-reported walking difficulty on bone mass and bone resorption marker in Japanese people aged 40 years and over
Tóm tắt
This study aimed to examine the association of walking difficulty with bone mass or bone turnover among community-dwelling Japanese people aged 40 years and older. We studied 1097 community-dwelling Japanese people aged 40 years and older (379 men and 718 women) who were invited to participate in periodic health examinations in 2006–2009. Walking difficulty was defined as having difficulty walking 100 m on a level surface (self-administered questionnaire). Calcaneal stiffness index (bone mass) was measured by quantitative ultrasound. Spot urine samples were collected, and urinary N-terminal cross-linking telopeptide of type I collagen (NTx) was measured. Values were corrected for creatinine (Cre) concentration. The prevalence of walking difficulty was significantly higher in women than in men (7.4 vs. 3.4 %, p = 0.011) and significantly increased with age in men (p for trend = 0.02) and women (p for trend <0.001). In univariate analysis, men and women with walking difficulty were older (p < 0.001) and had a lower stiffness index (p < 0.001), compared with those without walking difficulty. Among women, individuals with walking difficulty had significantly higher urinary NTx/Cre than those without walking difficulty (p < 0.001); however, this was not so among men (p = 0.39). Multiple regression analysis adjusted for age, weight, and menopausal status showed a significant association between walking difficulty and lower stiffness index in men (p = 0.004) and women (p = 0.005). In women, walking difficulty was significantly associated with higher NTx/Cre (p = 0.001), but not in men (p = 0.35). Walking difficulty may contribute to low bone mass in both sexes but might cause high bone turnover in women only.
Tài liệu tham khảo
Bauer DC, Gluer CC, Cauley JA, Vogt TM, Ensrud KE, Genant HK, et al. Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women. A prospective study. Study of Osteoporotic Fractures Research Group. Arch Intern Med. 1997;157(6):629–34.
Fujiwara S, Sone T, Yamazaki K, Yoshimura N, Nakatsuka K, Masunari N, et al. Heel bone ultrasound predicts non-spine fracture in Japanese men and women. Osteoporos Int. 2005;16(12):2107–12.
Hans D, Dargent-Molina P, Schott AM, Sebert JL, Cormier C, Kotzki PO, et al. Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study. Lancet. 1996;348(9026):511–4.
Huopio J, Kroger H, Honkanen R, Jurvelin J, Saarikoski S, Alhava E. Calcaneal ultrasound predicts early postmenopausal fractures as well as axial BMD. A prospective study of 422 women. Osteoporos Int. 2004;15(3):190–5.
Miller PD, Siris ES, Barrett-Connor E, Faulkner KG, Wehren LE, Abbott TA, et al. Prediction of fracture risk in postmenopausal white women with peripheral bone densitometry: evidence from the National Osteoporosis Risk Assessment. J Bone Miner Res. 2002;17(12):2222–30.
Garnero P, Hausherr E, Chapuy MC, Marcelli C, Grandjean H, Muller C, et al. Markers of bone resorption predict hip fracture in elderly women: the EPIDOS prospective study. J Bone Miner Res. 1996;11(10):1531–8.
Garnero P, Sornay-Rendu E, Claustrat B, Delmas PD. Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study. J Bone Miner Res. 2000;15(8):1526–36.
Gerdhem P, Ivaska KK, Alatalo SL, Halleen JM, Hellman J, Isaksson A, et al. Biochemical markers of bone metabolism and prediction of fracture in elderly women. J Bone Miner Res. 2004;19(3):386–93.
van Daele PL, Seibel MJ, Burger H, Hofman A, Grobbee DE, van Leeuwen JP, et al. Case-control analysis of bone resorption markers, disability, and hip fracture risk: the Rotterdam study. Bmj. 1996;312(7029):482–3.
Rosen CJ, Hochberg MC, Bonnick SL, McClung M, Miller P, Broy S, et al. Treatment with once-weekly alendronate 70 mg compared with once-weekly risedronate 35 mg in women with postmenopausal osteoporosis: a randomized double-blind study. J Bone Miner Res. 2005;20(1):141–51.
Adami S, Giannini S, Giorgino R, Isaia G, Maggi S, Sinigaglia L, et al. The effect of age, weight, and lifestyle factors on calcaneal quantitative ultrasound: the ESOPO study. Osteoporos Int. 2003;14(3):198–207.
Blanchet C, Giguere Y, Prud'homme D, Turcot-Lemay L, Dumont M, Leduc G, et al. Leisure physical activity is associated with quantitative ultrasound measurements independently of bone mineral density in postmenopausal women. Calcif Tissue Int. 2003;73(4):339–49.
Devine A, Dhaliwal SS, Dick IM, Bollerslev J, Prince RL. Physical activity and calcium consumption are important determinants of lower limb bone mass in older women. J Bone Miner Res. 2004;19(10):1634–9.
Fukuharu M, Sato J, Ohsawa I, Oshida Y, Kuriki K, Shibata K, et al. Effects of lifestyle factors on ultrasonographically determined bone health in Japanese women. Public Health. 2001;115(2):146–51.
Landin-Wilhelmsen K, Johansson S, Rosengren A, Dotevall A, Lappas G, Bengtsson BA, et al. Calcaneal ultrasound measurements are determined by age and physical activity. Studies in two Swedish random population samples. J Intern Med. 2000;247(2):269–78.
Lin JD, Chen JF, Chang HY, Ho C. Evaluation of bone mineral density by quantitative ultrasound of bone in 16,862 subjects during routine health examination. Br J Radiol. 2001;74(883):602–6.
Iwamoto J, Takeda T, Ichimura S. Relationships among physical activity, metacarpal bone mass, and bone resorption marker in 70 healthy adult males. J Orthop Sci. 2002;7(1):6–11.
Welsh L, Rutherford OM. Hip bone mineral density is improved by high-impact aerobic exercise in postmenopausal women and men over 50 years. Eur J Appl Physiol Occup Physiol. 1996;74(6):511–7.
Woitge HW, Scheidt-Nave C, Kissling C, Leidig-Bruckner G, Meyer K, Grauer A, et al. Seasonal variation of biochemical indexes of bone turnover: results of a population-based study. J Clin Endocrinol Metab. 1998;83(1):68–75.
Yamazaki S, Ichimura S, Iwamoto J, Takeda T, Toyama Y. Effect of walking exercise on bone metabolism in postmenopausal women with osteopenia/osteoporosis. J Bone Miner Metab. 2004;22(5):500–8.
Kitagawa J, Nakahara Y. Associations of daily walking steps with calcaneal ultrasound parameters and a bone resorption marker in elderly Japanese women. J Physiol Anthropol. 2008;27(6):295–300.
Chen JS, Cameron ID, Cumming RG, Lord SR, March LM, Sambrook PN, et al. Effect of age-related chronic immobility on markers of bone turnover. J Bone Miner Res. 2006;21(2):324–31.
Huang C, Ross PD, Wasnich RD. Vertebral fracture and other predictors of physical impairment and health care utilization. Arch Intern Med. 1996;156(21):2469–75.
Camargos MC, Machado CJ, Rodrigues RN. Life expectancy among elderly Brazilians in 2003 according to different levels of functional disability. Cad Saude Publica. 2008;24(4):845–52.
Santos-Eggimann B, Cuenoud P, Spagnoli J, Junod J. Prevalence of frailty in middle-aged and older community-dwelling Europeans living in 10 countries. J Gerontol A Biol Sci Med Sci. 2009;64(6):675–81.
Ahacic K, Parker MG, Thorslund M. Mobility limitations in the Swedish population from 1968 to 1992: age, gender and social class differences. Aging (Milano). 2000;12(3):190–8.
Sun W, Watanabe M, Tanimoto Y, Kono R, Saito M, Hirota C, et al. Assessment of the best gait parameter in relation to bone status in community-dwelling young-old and old-old women in Japan. Arch Gerontol Geriatr. 2009;49(1):158–61.
Sorva A, Valimaki M, Risteli J, Risteli L, Elfving S, Takkunen H, et al. Serum ionized calcium, intact PTH and novel markers of bone turnover in bedridden elderly patients. Eur J Clin Invest. 1994;24(12):806–12.
Bischoff H, Stahelin HB, Vogt P, Friderich P, Vonthein R, Tyndall A, et al. Immobility as a major cause of bone remodeling in residents of a long-stay geriatric ward. Calcif Tissue Int. 1999;64(6):485–9.