Effect of selenium supplementation on musculoskeletal health in older women: a randomised, double-blind, placebo-controlled trial

Jha, 2015, Trends in media reports, oral bisphosphonate prescriptions, and hip fractures 1996-2012: an ecological analysis, J Bone Miner Res, 30, 2179, 10.1002/jbmr.2565 Cervellati, 2014, Oxidative stress and bone resorption interplay as a possible trigger for postmenopausal osteoporosis, BioMed Res Int, 2014, 10.1155/2014/569563 Väänänen, 2000, The cell biology of osteoclast function, J Cell Sci, 113, 377, 10.1242/jcs.113.3.377 Manolagas, 2010, From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis, Endocr Rev, 31, 266, 10.1210/er.2009-0024 Hoeg, 2012, Bone turnover and bone mineral density are independently related to selenium status in healthy euthyroid postmenopausal women, J Clin Endocrinol Metab, 97, 4061, 10.1210/jc.2012-2121 Duntas, 2009, Selenium and inflammation: underlying anti-inflammatory mechanisms, Horm Metab Res, 41, 443, 10.1055/s-0029-1220724 Battin, 2009, Antioxidant activity of sulfur and selenium: a review of reactive oxygen species scavenging, glutathione peroxidase, and metal-binding antioxidant mechanisms, Cell Biochem Biophys, 55, 1, 10.1007/s12013-009-9054-7 Zhang, 2014, Selenoproteins and selenium status in bone physiology and pathology, Biochim Biophys Acta, 1840, 3246, 10.1016/j.bbagen.2014.08.001 Jakob, 2002, Expression and regulation of thioredoxin reductases and other selenoproteins in bone, Methods Enzymol, 347, 168, 10.1016/S0076-6879(02)47015-2 Cao, 2012, Selenium deficiency decreases antioxidative capacity and is detrimental to bone microarchitecture in mice, J Nutr, 142, 1526, 10.3945/jn.111.157040 Moreno-Reyes, 2001, Selenium deficiency-induced growth retardation is associated with an impaired bone metabolism and osteopenia, J Bone Miner Res, 16, 1556, 10.1359/jbmr.2001.16.8.1556 Moreno-Reyes, 1998, Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status, N Engl J Med, 339, 1112, 10.1056/NEJM199810153391604 Beukhof, 2016, Selenium status is positively associated with bone mineral density in healthy aging European men, PLoS One, 11, 10.1371/journal.pone.0152748 Zhang, 2006, Antioxidant intake and risk of osteoporotic hip fracture in Utah: an effect modified by smoking status, Am J Epidemiol, 163, 9, 10.1093/aje/kwj005 Rayman, 2012, Selenium and human health, Lancet, 379, 1256, 10.1016/S0140-6736(11)61452-9 Johnson, 2010, Symposium on ‘geographical and geological influences on nutrition’: factors controlling the distribution of selenium in the environment and their impact on health and nutrition, Proc Nutr Soc, 69, 119, 10.1017/S0029665109991807 Lauretani, 2007, Association of low plasma selenium concentrations with poor muscle strength in older community-dwelling adults: the InCHIANTI Study, Am J Clin Nutr, 86, 347, 10.1093/ajcn/86.2.347 Schomburg, 2019, Selenoprotein-P deficiency predicts cardiovascular disease and death, Nutrients, 11, 10.3390/nu11081852 Alehagen, 2016, Supplementation with selenium and coenzyme Q10 reduces cardiovascular mortality in elderly with low selenium status. a secondary analysis of a randomised clinical trial, PLoS One, 11, 10.1371/journal.pone.0157541 Alehagen, 2017, Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10. A prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens, PLoS One, 12 Duffield-Lillico, 2002, Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial, Cancer Epidemiol Biomarkers Prev, 11, 630 Kohler, 2018, Selenium and type 2 diabetes: systematic review, Nutrients, 10, 10.3390/nu10121924 Marcocci, 2011, Selenium and the course of mild Graves' orbitopathy, N Engl J Med, 364, 1920, 10.1056/NEJMoa1012985 Rayman, 2012, A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin, PLoS One, 7, 10.1371/journal.pone.0045269 Eastell, 2007, Relationship of early changes in bone resorption to the reduction in fracture risk with risedronate: review of statistical analysis, J Bone Miner Res, 22, 1656, 10.1359/jbmr.07090b Hahn, 2008, Effects of bone disease and calcium supplementation on antioxidant enzymes in postmenopausal women, Clin Biochem, 41, 69, 10.1016/j.clinbiochem.2007.10.010 Eastell, 2003, Relationship of early changes in bone resorption to the reduction in fracture risk with risedronate, J Bone Miner Res, 18, 1051, 10.1359/jbmr.2003.18.6.1051 Rogers, 2009, A randomised, double-blinded, placebo-controlled, trial to determine the individual response in bone turnover markers to lasofoxifene therapy, Bone, 45, 1044, 10.1016/j.bone.2009.07.089 Frison, 1992, Repeated measures in clinical trials: analysis using mean summary statistics and its implications for design, Stat Med, 11, 1685, 10.1002/sim.4780111304 Hochberg, 1987 Naylor, 2016, Response of bone turnover markers to three oral bisphosphonate therapies in postmenopausal osteoporosis: the TRIO study, Osteoporos Int, 27, 21, 10.1007/s00198-015-3145-7