Effect of preoperative immunonutrition on complications after salvage surgery in head and neck cancer

Simon A. Mueller1, Catherine Mayer2, Beat Bojaxhiu3, Carla Aeberhard2, Philipp Schuetz4, Zeno Stanga2, Roland Giger1
1Department of Oto-Rhino-Laryngology, Head and Neck Surgery Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland
2Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland
3Department of Radiation Oncology Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland
4Department of Endocrinology, Diabetes and Clinical Nutrition University Department of Internal Medicine, Kantonsspital Aarau, 5001, Aarau, Switzerland

Tóm tắt

Từ khóa


Tài liệu tham khảo

Dormand E-L, Banwell PE, Goodacre TEE. Radiotherapy and wound healing. Int Wound J. 2005;2:112–27.

Robbins KT, Favrot S, Hanna D, Cole R. Risk of wound infection in patients with head and neck cancer. Head Neck. 1990;12:143–8.

Ravasco P, Monteiro-Grillo I, Camilo ME. Does nutrition influence quality of life in cancer patients undergoing radiotherapy? Radiother Oncol. 2003;67:213–20.

White JV, Guenter P, Jensen G, Malone A, Schofield M. Academy malnutrition work group, et al. consensus statement: academy of nutrition and dietetics and American Society for Parenteral and Enteral Nutrition. J Parenter Enter Nutr. 2012;36:275–83.

Farsi NJ, Rousseau M-C, Schlecht N, Castonguay G, Allison P, Nguyen-Tan PF, et al. Aetiological heterogeneity of head and neck squamous cell carcinomas: the role of human papillomavirus infections, smoking and alcohol. Carcinogenesis. 2017;38:1188–95.

Ross LJ, Wilson M, Banks M, Rezannah F, Daglish M. Prevalence of malnutrition and nutritional risk factors in patients undergoing alcohol and drug treatment. Nutrition. 2012;28:738–43.

Nichols AC, Kneuertz PJ, Deschler DG, Lin DT, Emerick KS, Clark JR, et al. Surgical salvage of the oropharynx after failure of organ-sparing therapy. Head Neck. 2011;33:516–24.

Kadota H, Fukushima J, Nakashima T, Kumamoto Y, Yoshida S, Yasumatsu R, et al. Comparison of salvage and planned pharyngolaryngectomy with jejunal transfer for hypopharyngeal carcinoma after chemoradiotherapy. Laryngoscope. 2010;120:1103–8.

Taki S, Homma A, Oridate N, Suzuki S, Suzuki F, Sakashita T, et al. Salvage surgery for local recurrence after chemoradiotherapy or radiotherapy in hypopharyngeal cancer patients. Eur Arch Otorhinolaryngol. 2010;267:1765–9.

Weber RS, Berkey BA, Forastiere A, Cooper J, Maor M, Goepfert H, et al. Outcome of salvage total laryngectomy following organ preservation therapy: the radiation therapy oncology group trial 91-11. Arch Otolaryngol Head Neck Surg. 2003;129:44–9.

Lin Y-C, Hsiao J-R, Tsai S-T. Salvage surgery as the primary treatment for recurrent oral squamous cell carcinoma. Oral Oncol. 2004;40:183–9.

Sorensen LD, McCarthy M, Baumgartner MB, Demars CS. Perioperative immunonutrition in head and neck cancer. Laryngoscope. 2009;119:1358–64.

Bharadwaj S, Trivax B, Tandon P, Alkam B, Hanouneh I, Steiger E. Should perioperative immunonutrition for elective surgery be the current standard of care? Gastroenterol Rep. 2016;4:87–95.

Hurwitz AA, Watkins SK. Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cells. Cancer Immunol Immunother. 2012;61:289–93.

Alazawi W, Pirmadjid N, Lahiri R, Bhattacharya S. Inflammatory and immune responses to surgery and their clinical impact. Ann Surg. 2016;264:73–80.

Marimuthu K, Varadhan KK, Ljungqvist O, Lobo DN. A meta-analysis of the effect of combinations of immune modulating nutrients on outcome in patients undergoing major open gastrointestinal surgery. Ann Surg. 2012;255:1060–8.

Zhang Y, Gu Y, Guo T, Li Y, Cai H. Perioperative immunonutrition for gastrointestinal cancer: a systematic review of randomized controlled trials. Surg Oncol. 2012;21:e87–95.

Aeberhard C, Mayer C, Meyer S, Mueller SA, Schuetz P, Stanga Z, et al. Effect of preoperative immunonutrition on postoperative short-term outcomes of patients with head and neck squamous cell carcinoma. Head Neck. 2018;40:1057–67.

Felekis D, Eleftheriadou A, Papadakos G, Bosinakou I, Ferekidou E, Kandiloros D, et al. Effect of perioperative immuno-enhanced enteral nutrition on inflammatory response, nutritional status, and outcomes in head and neck cancer patients undergoing major surgery. Nutr Cancer. 2010;62:1105–12.

Snyderman CH, Kachman K, Molseed L, Wagner R, D’Amico F, Bumpous J, et al. Reduced postoperative infections with an immune-enhancing nutritional supplement. Laryngoscope. 1999;109:915–21.

Turnock A, Calder PC, West AL, Izzard M, Morton RP, Plank LD. Perioperative immunonutrition in well-nourished patients undergoing surgery for head and neck cancer: evaluation of inflammatory and immunologic outcomes. Nutrients. 2013;5:1186–99.

Falewee MN, Schilf A, Boufflers E, Cartier C, Bachmann P, Pressoir M, et al. Reduced infections with perioperative immunonutrition in head and neck cancer: exploratory results of a multicenter, prospective, randomized, double-blind study. Clin Nutr. 2014;33:776–84.

Kondrup J, Rasmussen HH, Hamberg O, Stanga Z. Ad hoc ESPEN working group. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr. 2003;22:321–36.

Sobin LH, Gospodarowicz MK. Wittekind C. TNM classification of malignant tumours. 7th ed. Hoboken: Wiley-Blackwell; 2009.

Alexander JW, Supp DM. Role of arginine and Omega-3 fatty acids in wound healing and infection. Adv wound care. 2014;3:682–90.

Evans RW, Fernstrom JD, Thompson J, Morris SM, Kuller LH. Biochemical responses of healthy subjects during dietary supplementation with L-arginine. J Nutr Biochem. 2004;15:534–9.

Buzby GP, Knox LS, Crosby LO, Eisenberg JM, Haakenson CM, McNeal GE, et al. Study protocol: a randomized clinical trial of total parenteral nutrition in malnourished surgical patients. Am J Clin Nutr. 1988;47(2 Suppl):366–81.

Dindo D, Demartines N, Clavien P-A. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–13.

de Luis DA, Izaola O, Cuellar MC, Terroba T, Aller R. High dose of arginine enhanced enteral nutrition in postsurgical head and neck cancer patients. A randomized clinical trial. Eur Rev Med Pharmacol Sci. 2009;13:279–83.

de Luis DA, Izaola O, Cuellar L, Terroba MC, Aller R. Randomized clinical trial with an enteral arginine-enhanced formula in early postsurgical head and neck cancer patients. Eur J Clin Nutr. 2004;58:1505–8.

de Luis D, Aller R, Izaola O, Cuellar L, Terroba M. Postsurgery enteral nutrition in head and neck cancer patients. Eur J Clin Nutr. 2002;56:1126–9.

van Bokhorst-De Van Der Schueren MA, Quak JJ, von Blomberg-van der Flier BM, Kuik DJ, Langendoen SI, Snow GB, et al. Effect of perioperative nutrition, with and without arginine supplementation, on nutritional status, immune function, postoperative morbidity, and survival in severely malnourished head and neck cancer patients. Am J Clin Nutr. 2001;73:323–32.

Weimann A, Braga M, Carli F, Higashiguchi T, Hübner M, Klek S, et al. ESPEN guideline: Clinical nutrition in surgery. Clin Nutr. 2017;36:623–50.

McClave SA, Martindale RG, Vanek VW, McCarthy M, Roberts P, Taylor B, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient. J Parenter Enter Nutr. 2009;33:277–316.

Stableforth WD, Thomas S, Lewis SJ. A systematic review of the role of immunonutrition in patients undergoing surgery for head and neck cancer. Int J Oral Maxillofac Surg. 2009;38:103–10.

Riso S, Aluffi P, Brugnani M, Farinetti F, Pia F, D’Andrea F. Postoperative enteral immunonutrition in head and neck cancer patients. Clin Nutr. 2000;19:407–12.

de Luis DA, Izaola O, Cuellar L, Terroba MC, Martin T, Aller R. Clinical and biochemical outcomes after a randomized trial with a high dose of enteral arginine formula in postsurgical head and neck cancer patients. Eur J Clin Nutr. 2007;61:200–4.

de Luis DA, Izaola O, Aller R, Cuellar L, Terroba MC. A randomized clinical trial with oral Immunonutrition (omega3-enhanced formula vs. arginine-enhanced formula) in ambulatory head and neck cancer patients. Ann Nutr Metab. 2005;49:95–9.

Denham JW, Hauer-Jensen M. The radiotherapeutic injury – a complex ‘wound’. Radiother Oncol. 2002;63:129–45.

Miller SH, Rudolph R. Healing in the irradiated wound. Clin Plast Surg. 1990;17:503–8.

Olascoaga A, Vilar-Compte D, Poitevin-Chacón A, Contreras-Ruiz J. Wound healing in radiated skin: pathophysiology and treatment options. Int Wound J. 2008;5:246–57.

Tibbs MK. Wound healing following radiation therapy: a review. Radiother Oncol. 1997;42:99–106.

Popovic PJ, Zeh HJ, Ochoa JB. Arginine and immunity. J Nutr. 2007;137(6 Suppl 2):1681S–6S.

Bronte V, Zanovello P. Regulation of immune responses by L-arginine metabolism. Nat Rev Immunol. 2005;5:641–54.

Wu G, Bazer FW, Burghardt RC, Johnson GA, Kim SW, Knabe DA, et al. Proline and hydroxyproline metabolism: implications for animal and human nutrition. Amino Acids. 2011;40:1053–63.

Barbul A. Proline precursors to sustain mammalian collagen synthesis. J Nutr. 2008;138:2021S–4S.