Effect of postconditioning and atorvastatin in preventing remote intestinal reperfusion injury

Journal of Coloproctology - Tập 37 - Trang 301-305 - 2017
Carlos Henrique Marques dos Santos1, Doroty Mesquita Dourado1, Trícia Luna Sampaio1, Letícia do Espirito Santo Dias1, Murillo Henrique Martins de Almeida1, João Victor Durães Gomes Oliva1, Ian de Oliveira Chaves1, Henrique Budib Dorsa Pontes2
1Universidade Anhanguera-Uniderp, Campo Grande, MS, Brazil
2Universidade Anhanguera (UNIDERP), Campo Grande, MS, Brazil

Tóm tắt

Abstract Objective To evaluate the capacity of ischemic postconditioning and atorvastatin in prevent or minimize reperfusion injury in small bowel of rats subjected to ischemia and reperfusion by abdominal aorta clamping. Methods 41 Wistar norvegic rats were distributed into 5 groups: ischemia and reperfusion, ischemic postconditioning, postconditioning + statin, statin and Sham. After anesthesia, laparotomy and dissection of the infra-renal abdominal aorta were performed; except the Sham group, all others were subjected to aorta clamping for 70 min (ischemia) and withdrawal of clamp for 70 min (reperfusion). In the IPC and IPC + S groups, four cycles of postconditioning were performed between the phases of ischemia and reperfusion lasting 30 s each. In IPC + S and S groups, 3.4 mg/day of atorvastatin was given for seven days per gavage; 1 cm of the ileum were removed for histological study and the results were subjected to statistical treatment considering significant p < 0.05. Results The average of intestinal lesion was 2 in the I/R group, 0.66 in the IPC group, 0 in the IPC + S group, 0 in the S group, and 0 in the SHAM group. Conclusion The ischemic postconditioning and atorvastatin were capable of minimizing intestinal reperfusion injury, either alone or in combination.

Tài liệu tham khảo

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Thông tin xuất bản

Journal of Coloproctology

Tập 37

301-305

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