Effect of polyphenols on the intestinal and placental transport of some bioactive compounds

Nutrition Research Reviews - Tập 23 Số 1 - Trang 47-64 - 2010
Fátima Martel1, Rosário Monteiro, Conceição Calhau
1Department of Biochemistry, Faculty of Medicine (U-38, FCT), 4200-319 Porto, Portugal. [email protected]

Tóm tắt

Polyphenols are a group of widely distributed phytochemicals present in most foods of vegetable origin. A growing number of biological effects have been attributed to these molecules in the past few years and only recently has their interference with the transport capacity of epithelial barriers received attention. This review will present data obtained concerning the effect of polyphenols upon the transport of some compounds (organic cations, glucose and the vitamins thiamin and folic acid) at the intestinal and placental barriers. Important conclusions can be drawn: (i) different classes of polyphenols affect transport of these bioactive compounds at the intestinal epithelia and the placenta; (ii) different compounds belonging to the same phenolic family often possess opposite effects upon transport of a given molecule; (iii) the acute and chronic/short-term and long-term exposures to polyphenols do not produce parallel results and, therefore, care should be taken when extrapolating results; (iv) the effect of polyphenolics in combination may be very different from the expected ones taking into account the effect of each of these compounds alone, and so care should be taken when speculating on the effect of a drink based on the effect of one component only; (v) care should be taken in drawing conclusions for alcoholic beverages from results obtained with ethanol alone. Although most of the data reviewed in the present paper refer to in vitro experiments with cell-culture systems, these studies raise a concern about possible changes in the bioavailability of substrates upon concomitant ingestion of polyphenols.

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Tài liệu tham khảo

10.1021/jf020252e

10.1002/jsfa.1264

10.1016/S0005-2736(01)00340-6

10.1146/annurev.pharmtox.38.1.431

10.1139/y05-129

10.1093/ajcn/70.4.495

10.1055/s-2006-951745

10.1016/j.ejphar.2004.07.034

Walgren, 2000, Cellular uptake of dietary flavonoid quercetin 4′-β-glucoside by sodium-dependent glucose transporter SGLT1, J Pharmacol Exp Ther, 294, 837

Middleton, 2000, The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer, Pharmacol Rev, 52, 673

10.2174/0929867013372256

10.1007/s00210-005-0012-7

10.1002/(SICI)1098-2825(1997)11:5<287::AID-JCLA6>3.0.CO;2-4

10.1021/jf0627672

10.1146/annurev.pharmtox.42.082101.154309

10.1046/j.1525-1373.2000.22428.x

Araújo, 2007, Nutritional modulation of 3H-deoxy-glucose uptake by placental BeWo cells, Acta Physiologica, 191, 76

10.1007/s00232-007-9057-5

10.1055/s-2007-967172

Halsted, 1973, Intestinal malabsorption in folate-deficient alcoholics, Gastroenterology, 64, 526, 10.1016/S0016-5085(73)80121-0

10.2152/jmi.52.245

10.1007/s002100000223

10.1016/j.cardiores.2006.10.004

10.1021/jf048492c

Bryans, 2003, An investigation of the effects of black tea (Camellia sinensis) on postprandial glycaemia in healthy humans, Proc Nutr Soc, 62, 63A

10.1093/jn/132.4.630

10.1016/0006-3002(62)90543-7

10.1074/jbc.274.45.31925

10.2337/diabetes.54.10.3056

10.1111/j.1753-4887.1998.tb01670.x

10.1093/ajcn/62.6.1276

10.1016/S0753-3322(02)00205-6

10.1002/jps.10325

10.1007/s00424-004-1355-5

10.1093/ajcn/71.5.1295s

Walgren, 2000, Efflux of dietary flavonoid quercetin 4′-β-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2, J Pharmacol Exp Ther, 294, 830

10.1016/S0891-5849(01)00803-6

10.1152/ajpcell.1980.238.5.C160

10.1016/j.lfs.2004.12.008

Boros, 2000, Population thiamine status and varying cancer rates between Western, Asian and African countries, Anticancer Res, 20, 2245

10.2165/00003088-200342130-00001

10.1016/j.foodres.2003.11.008

10.1016/0006-291X(91)91647-U

Worthington-Roberts, 1999, Cherry and Merkatz's Complications of Pregnancy, 17

Hahn, 1995, Localisation of the high affinity facilitative glucose transporter protein GLUT 1 in the placenta of human, marmoset monkey (Callithrix jacchus) and rat at different developmental stages, Cell Tissue Res, 280, 49

10.1016/j.phytochem.2004.04.025

Jovanovic, 1998, Antioxidant Properties of Flavonoids: Reduction Potentials and Electron Transfer Reactions of Flavonoid Radicals

10.1007/s002100000335

Calhau, 2002, Regulation of [3H]MPP+ transport by phosphorylation/dephosphorylation pathways in RBE4 cells: role of ecto-alkaline phosphatase, Naunyn Schmiedebergs Arch Pharmacol, 365, 349, 10.1007/s00210-002-0542-1

10.1093/ajcn/81.1.230S

10.1016/S0167-4889(01)00175-6

10.1016/S0304-3835(00)00645-5

10.1007/s002100100476

10.1006/mgme.2000.3027

Kumar, 1998, Mechanism and regulation of riboflavin uptake by human renal proximal tubule epithelial cell line HK-2, Am J Physiol, 274, F104

10.1080/01635589209514201

10.1016/S0924-2244(00)00048-0

10.1093/ajcn/79.5.727

10.1146/annurev.nutr.20.1.561

10.1016/j.bcp.2006.07.004

10.1046/j.1440-1681.2000.03214.x

10.1016/S0953-6205(01)00170-4

10.1093/ajcn/71.6.1698S

Artursson, 1991, Cell cultures as models for drug absorption across the intestinal mucosa, Crit Rev Ther Drug Carrier Syst, 8, 305

10.1023/A:1012121632357

10.1615/CritRevTherDrugCarrierSyst.v14.i3.20

10.1016/S0016-5085(89)80072-1

10.1024/0300-9831.73.2.101

10.1016/j.febslet.2005.11.068

10.1016/j.foodchem.2008.01.009

10.1016/0378-4274(89)90168-9

10.1111/j.1753-4887.2000.tb01818.x

10.1016/S0006-2952(02)00888-2

10.1006/phrs.1999.0506

10.1002/jcb.10306

10.1002/(SICI)1097-0010(20000515)80:7<1094::AID-JSFA569>3.0.CO;2-1

10.1021/jf0511300

10.1079/BJN20041128

Gastaldi, 1988, Intestinal transport of thiamin and thiamin monophosphate in rat everted jejunal sacs: a comparative study using some potential inhibitors, Arch Int Physiol Biochim, 96, 223

Lemos, 2004, Intestinal thiamine uptake: characterization and nutritional modulation, FASEB J, 18, A708

10.1159/000199358

10.1152/ajpcell.1999.277.4.C645

10.1002/mnfr.200900007

Keating, 2006, Characteristics of thiamine uptake by the BeWo human trophoblast cell line, J Biochem Mol Biol, 39, 383

10.1097/01.ALC.0000159114.86360.B5

Hoyumpa, 1975, Thiamine transport across the rat intestine. II. Effect of ethanol, J Lab Clin Med, 86, 803

10.1038/sj.npp.1395211

Herbert, 1999, Modern Nutrition in Health and Disease, 433

10.1093/jn/130.2.129

10.1001/archneur.55.11.1449

10.3748/wjg.v12.i11.1657

10.1177/153537020122600402

10.1093/alcalc/35.Supplement_1.2

10.1093/jn/132.8.2367S

10.1024/0300-9831.72.1.53

10.1093/ajcn/33.12.2750

10.1007/s00394-007-0670-y

10.1007/978-1-59259-725-3_14

10.1016/S0083-6729(03)01012-4

10.1152/ajpcell.00594.2005

10.1074/jbc.272.17.11165

10.1016/j.ejphar.2006.09.004

10.1002/jcp.10324

10.1016/j.cell.2006.09.041

10.1056/NEJMp038186

10.1016/j.jnutbio.2007.01.007

10.1016/S0378-8741(01)00335-X

10.1055/s-2000-8561

10.1093/ajcn/78.4.728

10.1016/S1521-6918(03)00107-0

10.1016/j.febslet.2004.12.099

10.1021/jf0006832

10.1002/biof.5520130111

Kreydiyyeh, 1994, Tea extracts inhibit intestinal absorption of glucose and sodium in rats, Comp Biochem Physiol, 108c, 359

10.1016/S0891-5849(98)00020-3

10.1007/BF00343939

10.1124/jpet.107.124040

10.1042/bj3500155

10.1096/fj.06-6620com

10.1074/jbc.M110496200

10.1007/BF00234938

10.3181/00379727-35-8858P

10.1093/jn/119.11.1698

10.1152/physrev.1978.58.2.499

10.1071/RD9950539

10.1007/BF01871036

10.1016/0005-2736(85)90472-9

10.1016/0143-4004(95)90031-4

Araújo, 2007, Nutritional modulation of glucose uptake by BeWo cells, Placenta, 28, A33

10.1093/jb/mvn054

10.1021/jf000549h

10.1016/0304-3940(89)90445-X

10.1002/biof.5520130119

10.1271/bbb.57.525

10.1016/S1521-6918(03)00034-9

10.1056/NEJM197109232851301

10.1023/A:1012102522787

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Nutrition Research Reviews

Tập 23 Số 1

47-64

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