Effect of non-steroidal anti-inflammatory agents on plasma protein concentration of ponies
Tóm tắt
The recent findings of oral phenylbutazone administration causing a protein-losing gastroenteropathy in ponies are described. Similar investigations in ponies using either meclofenamic acid or naproxen at the therapeutic dose for two weeks followed by a further week of treatment at twice this dose rate were carried out. Neither drug produced any adverse clinical signs. Although a decrease in total plasma protein occurred with meclofenamic acid, this was not associated with a protein-losing gastroenteropathy.
Tài liệu tham khảo
Snow, D.H., Bogan, J.A., Douglas, T.A. and Thompson, H., 1979. Phenylbutazone toxicity in ponies. Vet. Rec., 105: 26–30.
Snow, D.H., Douglas, T.A., Thompson, H., Parkins, J.J. and Holmes, F.H., 1981. Phenylbutazone toxicosis in Equidae: A biochemical and pathophysiologic study. Am. J. Vet. Res., 42: 1754–1759.