Effect of methionine and vitamin C supplementation on pulmonary glutathione-s-transferase and glutathione levels in ageing rats
Tóm tắt
Glutathione-5-transferase (GST) and glutathione (GSH) levels were estimated in the lungs of 3 and 30 months old rats. GST activity was found to be significantly reduced in the old rats (30 months age) compared to the young rats (3 months age). In old rats, with methionine supplementation GST activity was increased whereas with vitamin C supplementation GSH levels were increased. The data show that the supplementation of methionine as well as of vitamin C have beneficial effect on the scavenging system and protect lungs against the free radical damage during ageing.
Tài liệu tham khảo
Halliwell, B. and Gutteridge, J.M.C. (1985). Free Radicals in Biology and Medicine. Clarendon Press, Oxford, pp 104–106.
Slater, T.F., Cheeseman, K.S., Davies, M.J., Proudfoot, K. and Xin, W. (1987). Pro. Nutr. Soc. 46, 1–12.
Harman, D. (1986). In: Biology of Ageing (Johnson, J., Walford, R., Harman, D. and Migwel, J., eds.) Lis, New York, pp 3–50.
Sparnins, V.L., Venegas, P.L. and Wattenberg, L.W. (1982). J. Wat. Cancer Inst. 68, 493–496.
Tateshi, N., Higashi, T., Shinya, S., Naruse, A. and Sakamoto, Y. (1974). J. Biochem. 75, 93–103.
Seligson, F.H. and Rotruck, J.T. (1983). J. Nutr. 113, 98–104.
Barber, A. and Bernhaim, F. (1967). Adv. in Gernotl. Res., Vol. 2, (Strechler, B.L., ed.) Academic Press, New York, pp 355–403.
Habig, W.H., Pabst, M.J. and Jakoby, W.B. (1974). J. Biol. Chem. 249, 7130–7139.
Beutler, E., Duron, O. and Kely, B.M. (1983). J. Lab. Clin. Med. 61, 882–888.
Dhrloff, C., Hockwin, O., Olson, R. and Dickman, S. (1984). Curr. Eye. Res. 3, 109–115.
Danh, H.C., Benedetti, M.S. and Dostert, P. (1983). J. Neurochem. 40, 1003–1007.
Davasagayam, T.P. (1986). FEBS Lett. 205, 246–250.
Denake, S.M., Gershof, S.N. and Fanburg, B.L. (1983). J. Appl. Physiol. 54, 147–152.
Fre, B., England, L. and Ames, B.N. (1989). Proc. Natl. Acad. Sci. USA. 86, 6377–6381.