Effect of maternal PCOS and PCOS-like phenotype on the offspring's health
Tài liệu tham khảo
Abbott, 1998, Insights into the development of polycystic ovary syndrome (PCOS) from studies of prenatally androgenized female rhesus monkeys, Trends Endocrinol. Metab., 9, 62, 10.1016/S1043-2760(98)00019-8
Abbott, 2005, Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?, Hum. Reprod. Update, 11, 357, 10.1093/humupd/dmi013
Abbott, 2008, Endocrine antecedents of polycystic ovary syndrome in fetal and infant prenatally androgenized female rhesus monkeys, Biol. Reprod., 79, 154, 10.1095/biolreprod.108.067702
Abbott, 2008, Fetal programming of adrenal androgen excess: lessons from a nonhuman primate model of polycystic ovary syndrome, Endocr. Dev., 13, 145, 10.1159/000134831
Abbott, 2009, Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys, Am. J. Primatol., 71, 776, 10.1002/ajp.20679
Abi Salloum, 2012, Developmental programming: prenatal and postnatal contribution of androgens and insulin in the reprogramming of estradiol positive feedback disruptions in prenatal testosterone-treated sheep, Endocrinology, 153, 2813, 10.1210/en.2011-2074
Abi Salloum, 2015, Developmental programming: exposure to testosterone excess disrupts steroidal and metabolic environment in pregnant sheep, Endocrinology, 156, 2323, 10.1210/en.2014-2006
Altieri, 2010, Maternal polycystic ovary syndrome may be associated with adverse pregnancy outcomes, Eur. J. Obstet. Gynecol. Reprod. Biol., 149, 31, 10.1016/j.ejogrb.2009.11.010
Anderson, 2010, Infants of women with polycystic ovary syndrome have lower cord blood androstenedione and estradiol levels, J. Clin. Endocrinol. Metab., 95, 2180, 10.1210/jc.2009-2651
Anderson, 2014, Childhood obesity and its impact on the development of adolescent PCOS, Seminars Reproductive Med., 32, 202, 10.1055/s-0034-1371092
Ahrenfeldt, 2015, Academic performance of opposite-sex and same-sex twins in adolescence: a Danish national cohort study, Horm. Behav., 69, 123, 10.1016/j.yhbeh.2015.01.007
Bahrke, 1998, Anabolic-androgenic steroid abuse and performance-enhancing drugs among adolescents, Child. Adolesc. Psychiatr. Clin. N. Am., 7, 821, 10.1016/S1056-4993(18)30214-1
Baird, 1977, Pituitary-ovarian relationships in polycystic ovary syndrome, J. Clin. Endocrinol. Metab., 45, 798, 10.1210/jcem-45-4-798
Barker, 2004, The developmental origins of adult disease, J. Am. Coll. Nutr., 23, 588S, 10.1080/07315724.2004.10719428
Barnes, 1994, Ovarian hyperandrogynism as a result of congenital adrenal virilizing disorders: evidence for perinatal masculinization of neuroendocrine function in women, J. Clin. Endocrinol. Metab., 79, 1328
Barrett, 2014, Polycystic ovary syndrome: do endocrine-disrupting chemicals play a role?, Semin. Reprod. Med., 32, 166, 10.1055/s-0034-1371088
Barry, 2010, Umbilical vein testosterone in female infants born to mothers with polycystic ovary syndrome is elevated to male levels, J. Obstet. Gynaecol., 30, 444, 10.3109/01443615.2010.485254
Bassiouny, 2014, Association of the luteinizing hormone/choriogonadotropin receptor gene polymorphism with polycystic ovary syndrome, Gynecol. Endocrinol., 30, 428, 10.3109/09513590.2014.895982
Battaglia, 2002, Polycystic ovaries in childhood: a common finding in daughters of PCOS patients. A pilot study, Hum. Reprod., 17, 771, 10.1093/humrep/17.3.771
Bayer, 1999, Genetic and non-genetic vulnerability factors in schizophrenia: the basis of the “two hit hypothesis”, J. Psychiatr. Res., 33, 543, 10.1016/S0022-3956(99)00039-4
Beck-Peccoz, 1991, J. Clin. Endocrinol. Metab., 73, 525, 10.1210/jcem-73-3-525
Beckett, 2014, Developmental programming: impact of testosterone on placental differentiation, Reproduction, 148, 199, 10.1530/REP-14-0055
Birch, 2003, Prenatal programming of reproductive neuroendocrine function: fetal androgen exposure produces progressive disruption of reproductive cycles in sheep, Endocrinology, 144, 1426, 10.1210/en.2002-220965
Boomsma, 2006, A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome, Hum. Reprod. Update, 12, 673, 10.1093/humupd/dml036
Bremer, 2010, Polycystic ovary syndrome in the pediatric population, Metab. Syndr. Relat. Disord., 8, 375, 10.1089/met.2010.0039
Brettenthaler, 2004, Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome, J. Clin. Endocrinol. Metabol., 89, 3835, 10.1210/jc.2003-031737
Capalbo, 2012, The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2.7-fold increased risk of polycystic ovary syndrome in a Sardinian population, Clin. Endocrinol. (Oxf), 77, 113, 10.1111/j.1365-2265.2012.04372.x
Cardoso, 2015, Steroidogenic versus metabolic programming of reproductive neuroendocrine, ovarian and metabolic dysfunctions, Neuroendocrinology, 102, 226, 10.1159/000381830
Cernea, 2011
Chen, 2011, Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3, Nat. Genet., 43, 55, 10.1038/ng.732
Cianfarani, 1999, Low birthweight and adult insulin resistance: the “catch-up growth” hypothesis, Arch. Dis. Childhood-Fetal Neonatal Ed., 81, F71, 10.1136/fn.81.1.F71
Conway, 2014, The polycystic ovary syndrome: a position statement from the European society of Endocrinology, Eur. J. Endocrinol., 171, P1, 10.1530/EJE-14-0253
Crespi, 2006, Prenatal exposure to excess testosterone modifies the developmental trajectory of the insulin-like growth factor system in female sheep, J. Physiol., 572, 119, 10.1113/jphysiol.2005.103929
Day, 2015, Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome, Nat. Commun., 6, 8464, 10.1038/ncomms9464
de Bruin, 1998, Fetal growth retardation as a cause of impaired ovarian development, Early Hum. Dev., 51, 39, 10.1016/S0378-3782(97)00073-X
de Melo, 2015, Pathogenesis of polycystic ovary syndrome: multifactorial assessment from the foetal stage to menopause, Reproduction, 150, R11, 10.1530/REP-14-0499
Diamanti-Kandarakis, 2012, Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications, Endocr. Rev., 33, 981, 10.1210/er.2011-1034
Doherty, 2015, Implications of polycystic ovary syndrome for pregnancy and for the health of offspring, Obstet. Gynecol., 125, 1397, 10.1097/AOG.0000000000000852
Dumesic, 2014, Intrauterine environment and polycystic ovary syndrome, Semin. Reprod. Med., 32, 159, 10.1055/s-0034-1371087
Dumesic, 2015, Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome, Endocr. Rev, 36, 487, 10.1210/er.2015-1018
Eagleson, 2000, Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone 1, J. Clin. Endocrinol. Metabol., 85, 4047
Eisner, 2002, Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess, Fertil. Steril., 77, 167, 10.1016/S0015-0282(01)02947-8
Eriksen, 2013, Genetic alterations within the DENND1A gene in patients with polycystic ovary syndrome (PCOS), PLoS One, 8, e77186, 10.1371/journal.pone.0077186
Ewens, 2010, Family-based analysis of candidate genes for polycystic ovary syndrome, J. Clin. Endocrinol. Metab., 95, 2306, 10.1210/jc.2009-2703
Fauser, 2012, Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS consensus workshop group, Fertil. Steril., 97, 28, 10.1016/j.fertnstert.2011.09.024
Fowden, 2006, Intrauterine programming of physiological systems: causes and consequences, Physiol. (Bethesda), 21, 29, 10.1152/physiol.00050.2005
Franks, 1997, The genetic basis of polycystic ovary syndrome, Hum. Reprod., 12, 2641, 10.1093/humrep/12.12.2641
Franks, 2006, Development of polycystic ovary syndrome: involvement of genetic and environmental factors, Int. J. Androl., 29, 278, 10.1111/j.1365-2605.2005.00623.x
Franks, 2008, Polycystic ovary syndrome in adolescents, Int. J. Obes., 32, 1035, 10.1038/ijo.2008.61
Gonzalez, 2005, Hyperglycemia alters tumor necrosis factor-alpha release from mononuclear cells in women with polycystic ovary syndrome, J. Clin. Endocrinol. Metab., 90, 5336, 10.1210/jc.2005-0694
Gonzalez, 2012, Inflammation in polycystic ovary Syndrome: underpinning of insulin resistance and ovarian dysfunction, Steroids, 77, 300, 10.1016/j.steroids.2011.12.003
Goodarzi, 2011, Polycystic ovary syndrome: etiology, pathogenesis and diagnosis, Nat. Rev. Endocrinol., 7, 219, 10.1038/nrendo.2010.217
Goodarzi, 2012, Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts, J. Med. Genet., 49, 90, 10.1136/jmedgenet-2011-100427
Gore, 2008, Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems, Front. Neuroendocrinol., 29, 358, 10.1016/j.yfrne.2008.02.002
Gude, 2004, Growth and function of the normal human placenta, Thromb. Res., 114, 397, 10.1016/j.thromres.2004.06.038
Ha, 2015, Association study between polycystic ovarian syndrome and the susceptibility genes polymorphisms in Hui Chinese women, PLoS One, 10, e0126505, 10.1371/journal.pone.0126505
Hague, 1990, The prevalence of polycystic ovaries in patients with congenital adrenal hyperplasia and their close relatives, Clin. Endocrinol. (Oxf), 33, 501, 10.1111/j.1365-2265.1990.tb03887.x
Hayes, 2015, Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations, Nat. Commun., 6, 7502, 10.1038/ncomms8502
Hickey, 2009, The relationship between maternal and umbilical cord androgen levels and polycystic ovary syndrome in adolescence: a prospective cohort study, J. Clin. Endocrinol. Metab., 94, 3714, 10.1210/jc.2009-0544
Hickey, 2002, The androgen receptor CAG repeat polymorphism and X-chromosome inactivation in Australian Caucasian women with infertility related to polycystic ovary syndrome, J. Clin. Endocrinol. Metab., 87, 161, 10.1210/jcem.87.1.8137
Hickey, 2006, Epigenetic modification of the X chromosome influences susceptibility to polycystic ovary syndrome, J. Clin. Endocrinol. Metab., 91, 2789, 10.1210/jc.2006-0069
Hogeveen, 2002, Human sex hormone-binding globulin variants associated with hyperandrogenism and ovarian dysfunction, J. Clin. Invest, 109, 973, 10.1172/JCI0214060
Huber-Buchholz, 1999, Restoration of reproductive potential by lifestyle modification in obese polycystic ovary syndrome: role of insulin sensitivity and luteinizing hormone, J. Clin. Endocrinol. Metab., 84, 1470
Ibanez, 1998, Precocious pubarche, hyperinsulinism, and ovarian hyperandrogenism in girls: relation to reduced fetal growth, J. Clin. Endocrinol. Metab., 83, 3558, 10.1210/jcem.83.10.5205
Jackson, 2008, Sexual differentiation of the external genitalia and the timing of puberty in the presence of an antiandrogen in sheep, Endocrinology, 149, 4200, 10.1210/en.2007-1382
Jackson, 2013, Developmental programming: postnatal steroids complete prenatal steroid actions to differentially organize the GnRH surge mechanism and reproductive behavior in female sheep, Endocrinology, 154, 1612, 10.1210/en.2012-1613
Jefferson, 2012, Reproductive consequences of developmental phytoestrogen exposure, Reproduction, 143, 247, 10.1530/REP-11-0369
Jindal, 2007, Placental pathology of recurrent spontaneous abortion: the role of histopathological examination of products of conception in routine clinical practice: a mini review, Hum. Reprod., 22, 313, 10.1093/humrep/del128
Jones, 2015, Systems genetics reveals the functional context of PCOS loci and identifies genetic and molecular mechanisms of disease heterogeneity, PLoS Genet., 11, e1005455, 10.1371/journal.pgen.1005455
Kandaraki, 2011, Endocrine disruptors and polycystic ovary syndrome (PCOS): elevated serum levels of bisphenol A in women with PCOS, J. Clin. Endocrinol. Metab., 96, E480, 10.1210/jc.2010-1658
Kauffman, 2015, A novel letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female mice, Biol. Reprod., 93, 69, 10.1095/biolreprod.115.131631
Kjerulff, 2011, Pregnancy outcomes in women with polycystic ovary syndrome: a metaanalysis, Am. J. Obstet. Gynecol., 204, e1
Kuijper, 2009, Prevalence of polycystic ovary syndrome in women from opposite-sex twin pairs, J. Clin. Endocrinol. Metab., 94, 1987, 10.1210/jc.2009-0191
Laitinen, 2003, Body size from birth to adulthood as a predictor of self-reported polycystic ovary syndrome symptoms, Int. J. Obes., 27, 710, 10.1038/sj.ijo.0802301
Legro, 1998, Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome, Proc. Natl. Acad. Sci. U. S. A., 95, 14956, 10.1073/pnas.95.25.14956
Levin, 1991, Is the inappropriate gonadotropin secretion of patients with polycystic ovary syndrome similar to that of patients with adult-onset congenital adrenal hyperplasia?, Fertil. Steril., 56, 635, 10.1016/S0015-0282(16)54592-0
Li, 2014, De novo synthesis of steroids and oxysterols in adipocytes, J. Biol. Chem., 289, 747, 10.1074/jbc.M113.534172
Li, 2012, Identification of YAP1 as a novel susceptibility gene for polycystic ovary syndrome, J. Med. Genet., 49, 254, 10.1136/jmedgenet-2011-100727
Li, 2008, Epigenetic abnormality: a possible mechanism underlying the fetal origin of polycystic ovary syndrome, Med. Hypotheses, 70, 638, 10.1016/j.mehy.2006.09.076
Loehlin, 2000, Dimensions of psychological masculinity-femininity in adult twins from opposite-sex and same-sex pairs, Behav. Genet., 30, 19, 10.1023/A:1002082325784
Louwers, 2013, Cross-ethnic meta-analysis of genetic variants for polycystic ovary syndrome, J. Clin. Endocrinol. Metab., 98, E2006, 10.1210/jc.2013-2495
Lu, 2015, Developmental programming: prenatal testosterone excess decreases insulin sensitivity in muscle and liver but not fat via AKT signaling pathway in female sheep, Endo, San Diego, CA Abstract # THR-623, 197
Maliqueo, 2013, Placental steroidogenesis in pregnant women with polycystic ovary syndrome, Eur. J. Obstet. Gynecol. Reprod. Biol., 166, 151, 10.1016/j.ejogrb.2012.10.015
Maliqueo, 2014, Rodent models of polycystic ovary syndrome: phenotypic presentation, pathophysiology, and the effects of different interventions, Semin. Reprod. Med., 32, 183, 10.1055/s-0034-1371090
Manikkam, 2004, Fetal programming: prenatal testosterone excess leads to fetal growth retardation and postnatal catch-up growth in sheep, Endocrinology, 145, 790, 10.1210/en.2003-0478
Manikkam, 2006, Fetal programming: prenatal testosterone treatment leads to follicular persistence/luteal defects; partial restoration of ovarian function by cyclic progesterone treatment, Endocrinology, 147, 1997, 10.1210/en.2005-1338
March, 2010, The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria, Hum. Reprod., 25, 544, 10.1093/humrep/dep399
Mcallister, 2015, Functional genomics of PCOS: from GWAS to molecular mechanisms, Trends Endocrinol. Metab., 26, 118, 10.1016/j.tem.2014.12.004
Mehrabian, 2012, Comparison of the metabolic parameters and androgen level of umbilical cord blood in newborns of mothers with polycystic ovary syndrome and controls, J. Res. Med. Sci., 17, 207
Melo, 2010, High prevalence of polycystic ovary syndrome in women born small for gestational age, Hum. Reprod., 25, 2124, 10.1093/humrep/deq162
Moghetti, 1996, The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment: evidence that androgens impair insulin action in women, J. Clin. Endocrinol. Metab., 81, 952
Moran, 2015, Metabolic risk in PCOS: phenotype and adiposity impact, Trends Endocrinol. Metab., 26, 136, 10.1016/j.tem.2014.12.003
Morishima, 1995, Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens, J. Clin. Endocrinol. Metab., 80, 3689
Mumm, 2013, Birth weight and polycystic ovary syndrome in adult life: a register-based study on 523,757 Danish women born 1973-1991, Fertil. Steril., 99, 777, 10.1016/j.fertnstert.2012.11.004
New, 2006, Extensive clinical experience: nonclassical 21-hydroxylase deficiency, J. Clin. Endocrinol. Metab., 91, 4205, 10.1210/jc.2006-1645
Ong, 2000, Association between postnatal catch-up growth and obesity in childhood: prospective cohort study, Bmj, 320, 967, 10.1136/bmj.320.7240.967
Orio, 2005, The increase of leukocytes as a new putative marker of low-grade chronic inflammation and early cardiovascular risk in polycystic ovary syndrome, J. Clin. Endocrinol. Metab., 90, 2, 10.1210/jc.2004-0628
Ortega, 2009, Developmental programming: prenatal androgen excess disrupts ovarian steroid receptor balance, Reproduction, 137, 865, 10.1530/REP-08-0491
Padmanabhan, 2006, Prenatal testosterone excess programs reproductive and metabolic dysfunction in the female, Mol. Cell Endocrinol., 246, 165, 10.1016/j.mce.2005.11.016
Padmanabhan, 2011, Developmental origin of reproductive and metabolic dysfunctions: androgenic versus estrogenic reprogramming, Semin. Reprod. Med., 29, 173, 10.1055/s-0031-1275519
Padmanabhan, 2013, Animal models of the polycystic ovary syndrome phenotype, Steroids, 78, 734, 10.1016/j.steroids.2013.05.004
Padmanabhan, 2013, Sheep models of polycystic ovary syndrome phenotype, Mol. Cell Endocrinol., 373, 8, 10.1016/j.mce.2012.10.005
Padmanabhan, 2015, Developmental programming: prenatal and postnatal androgen antagonist and insulin sensitizer interventions prevent advancement of puberty and improve LH surge dynamics in prenatal testosterone-treated sheep, Endocrinology, 156, 2678, 10.1210/en.2015-1235
Palomba, 2006, Uterine effects of metformin administration in anovulatory women with polycystic ovary syndrome, Hum. Reprod., 21, 457, 10.1093/humrep/dei351
Palomba, 2010, Uterine blood flow in pregnant patients with polycystic ovary syndrome: relationships with clinical outcomes, BJOG, 117, 711, 10.1111/j.1471-0528.2010.02525.x
Palomba, 2012, Pervasive developmental disorders in children of hyperandrogenic women with polycystic ovary syndrome: a longitudinal case-control study, Clin. Endocrinol. (Oxf), 77, 898, 10.1111/j.1365-2265.2012.04443.x
Palomba, 2012, Decidual endovascular trophoblast invasion in women with polycystic ovary syndrome: an experimental case-control study, J. Clin. Endocrinol. Metab., 97, 2441, 10.1210/jc.2012-1100
Palomba, 2013, Macroscopic and microscopic findings of the placenta in women with polycystic ovary syndrome, Hum. Reprod., 28, 2838, 10.1093/humrep/det250
Pantasri, 2014, The effects of being overweight and obese on female reproduction: a review, Gynecol. Endocrinol., 30, 90, 10.3109/09513590.2013.850660
Paradisi, 2001, Polycystic ovary syndrome is associated with endothelial dysfunction, Circulation, 103, 1410, 10.1161/01.CIR.103.10.1410
Pasquali, 2013, Insulin sensitizers in polycystic ovary syndrome, Front. Horm. Res., 40, 83, 10.1159/000341837
Peretz, 2014, Bisphenol a and reproductive health: update of experimental and human evidence, 2007-2013, Environ. Health Perspect., 122, 775, 10.1289/ehp.1307728
Prefumo, 2004, Decreased endovascular trophoblast invasion in first trimester pregnancies with high-resistance uterine artery doppler indices, Hum. Reprod., 19, 206, 10.1093/humrep/deh037
Qin, 2013, Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis, Reprod. Biol. Endocrinol., 11, 56, 10.1186/1477-7827-11-56
Reinehr, 2005, Androgens before and after weight loss in obese children, J. Clin. Endocrinol. Metabol., 90, 5588, 10.1210/jc.2005-0438
Rhind, 2001, Effects of nutrition and environmental factors on the fetal programming of the reproductive axis, Reproduction, 122, 205, 10.1530/rep.0.1220205
Sathishkumar, 2011, Prenatal testosterone-induced fetal growth restriction is associated with down-regulation of rat placental amino acid transport, Reprod. Biol. Endocrinol., 9, 110, 10.1186/1477-7827-9-110
Shah, 2008, Association of androgen receptor CAG repeat polymorphism and polycystic ovary syndrome, J. Clin. Endocrinol. Metab., 93, 1939, 10.1210/jc.2008-0038
Shi, 2012, Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome, Nat. Genet., 44, 1020, 10.1038/ng.2384
Sir-Petermann, 2002, Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization, Hum. Reprod., 17, 2573, 10.1093/humrep/17.10.2573
Sir-Petermann, 2005, Birth weight in offspring of mothers with polycystic ovarian syndrome, Hum. Reprod., 20, 2122, 10.1093/humrep/dei009
Sir-Petermann, 2007, Serum adiponectin and lipid concentrations in pregnant women with polycystic ovary syndrome, Hum. Reprod., 22, 1830, 10.1093/humrep/dem090
Sir-Petermann, 2007, Early metabolic derangements in daughters of women with polycystic ovary syndrome, J. Clin. Endocrinol. Metabol., 92, 4637, 10.1210/jc.2007-1036
Sir-Petermann, 2009, Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome, J. Clin. Endocrinol. Metabol., 94, 1923, 10.1210/jc.2008-2836
Sir-Petermann, 2012, [Polycystic ovary syndrome and pregnancy], Rev. Med. Chil., 140, 919, 10.4067/S0034-98872012000700015
Slob, 1983, Prenatal testosterone propionate and postnatal ovarian activity in the rat, Acta Endocrinol. (Copenh), 103, 420, 10.1530/acta.0.1030420
Smith, 2010, Maternal androgen levels during pregnancy are associated with early-life growth in Geoffroy's marmosets, Callithrix geoffroyi, Gen. Comp. Endocrinol., 166, 307, 10.1016/j.ygcen.2009.10.008
Smithells, 1981, Oral contraceptives and birth defects, Dev. Med. Child. Neurol., 23, 369, 10.1111/j.1469-8749.1981.tb02469.x
Smushkin, 2010, Genetics of type 2 diabetes, Curr. Opin. Clin. Nutr. Metab. Care, 13, 471, 10.1097/MCO.0b013e32833a558d
Spaczynski, 1999, Tumor necrosis factor-alpha stimulates proliferation of rat ovarian theca-interstitial cells, Biol. Reprod., 61, 993, 10.1095/biolreprod61.4.993
Steckler, 2005, Fetal programming: prenatal testosterone treatment causes intrauterine growth retardation, reduces ovarian reserve and increases ovarian follicular recruitment, Endocrinology, 146, 3185, 10.1210/en.2004-1444
Steckler, 2009, Developmental programming: excess weight gain amplifies the effects of prenatal testosterone excess on reproductive cyclicity—implication for polycystic ovary syndrome, Endocrinology, 150, 1456, 10.1210/en.2008-1256
Sun, 2012, Maternal androgen excess reduces placental and fetal weights, increases placental steroidogenesis, and leads to long-term health effects in their female offspring, Am. J. Physiol. Endocrinol. Metab., 303, E1373, 10.1152/ajpendo.00421.2012
Takeuchi, 2004, Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction, Endocr. J., 51, 165, 10.1507/endocrj.51.165
Tang, 2008, Persistent hypomethylation in the promoter of nucleosomal binding protein 1 (Nsbp1) correlates with overexpression of Nsbp1 in mouse uteri neonatally exposed to diethylstilbestrol or genistein, Endocrinology, 149, 5922, 10.1210/en.2008-0682
Tul, 2012, No “masculinization” effect of a male on birth weight of its female co-twin, J. Perinat. Med., 40, 255
Urbanek, 1999, Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin, Proc. Natl. Acad. Sci. U. S. A., 96, 8573, 10.1073/pnas.96.15.8573
Urbanek, 2005, Candidate gene region for polycystic ovary syndrome on chromosome 19p13.2, J. Clin. Endocrinol. Metab., 90, 6623, 10.1210/jc.2005-0622
van der Spuy, 2004, The pathogenesis of infertility and early pregnancy loss in polycystic ovary syndrome, Best. Pract. Res. Clin. Obstet. Gynaecol., 18, 755, 10.1016/j.bpobgyn.2004.06.001
van Houten, 2014, Mouse models to study polycystic ovary syndrome: a possible link between metabolism and ovarian function?, Reprod. Biol., 14, 32, 10.1016/j.repbio.2013.09.007
van Wagenen, 1949, Accelerated growth with sexual precocity in female monkeys receiving testosterone propionate, Endocrinology, 45, 544, 10.1210/endo-45-5-544
Veiga-Lopez, 2010, Developmental programming: insulin sensitizer treatment improves reproductive function in prenatal testosterone-treated female sheep, Endocrinology, 151, 4007, 10.1210/en.2010-0124
Veiga-Lopez, 2011, Developmental programming: impact of excess prenatal testosterone on intrauterine fetal endocrine milieu and growth in sheep, Biol. Reprod., 84, 87, 10.1095/biolreprod.110.086686
Veiga-Lopez, 2014, Developmental programming: postnatal estradiol amplifies ovarian follicular defects induced by fetal exposure to excess testosterone and dihydrotestosterone in sheep, Reprod. Sci., 21, 444, 10.1177/1933719113503412
Vink, 2006, Heritability of polycystic ovary syndrome in a Dutch twin-family study, J. Clin. Endocrinol. Metab., 91, 2100, 10.1210/jc.2005-1494
Xia, 2015, Epigenetic pattern changes in prenatal female Sprague-Dawley rats following exposure to androgen, Reprod. Fertil. Dev.
Xita, 2010, Fetal origins of the metabolic syndrome, Ann. N. Y. Acad. Sci., 1205, 148, 10.1111/j.1749-6632.2010.05658.x
Xu, 2010, Epigenetics in polycystic ovary syndrome: a pilot study of global DNA methylation, Fertil. Steril., 94, 781, 10.1016/j.fertnstert.2009.10.020
Xu, 2011, Epigenetic mechanism underlying the development of polycystic ovary syndrome (PCOS)-like phenotypes in prenatally androgenized rhesus monkeys, PLoS One, 6, e27286, 10.1371/journal.pone.0027286
Yildiz, 2008, Impact of obesity on the risk for polycystic ovary syndrome, J. Clin. Endocrinol. Metab., 93, 162, 10.1210/jc.2007-1834
Zhang, 2014, Genome-wide identification of aberrantly methylated promoters in ovarian tissue of prenatally androgenized rats, Fertil. Steril., 102, 1458, 10.1016/j.fertnstert.2014.07.1203
Zhao, 2015, Family-based analysis of eight susceptibility loci in polycystic ovary syndrome, Sci. Rep., 5, 12619, 10.1038/srep12619
Zhou, 2007, Pioglitazone improves insulin action and normalizes menstrual cycles in a majority of prenatally androgenized female rhesus monkeys, Reprod. Toxicol., 23, 438, 10.1016/j.reprotox.2006.12.009
Zhou, 2008, Effect of bisphenol A on steroid hormone production in rat ovarian theca-interstitial and granulosa cells, Mol. Cell Endocrinol., 283, 12, 10.1016/j.mce.2007.10.010