Effect of intravenous administration of ketamine on the minimum alveolar concentration of isoflurane in anesthetized dogs

American Journal of Veterinary Research - Tập 67 Số 1 - Trang 21-25 - 2006
Alberto Solano1, Bruno H. Pypendop2, Pedro Boscan3, Jan E. Ilkiw2
1Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA
2Surgical and Radiological Sciences
3UNIVERSITY OF CALIFORNIA AT DAVIS

Tóm tắt

Abstract Objective—To determine the effect of 6 plasma ketamine concentrations on the minimum alveolar concentration (MAC) of isoflurane in dogs. Animals—6 dogs. Procedure—In experiment 1, the MAC of isoflurane was measured in each dog and the pharmacokinetics of ketamine were determined in isoflurane-anesthetized dogs after IV administration of a bolus (3 mg/kg) of ketamine. In experiment 2, the same dogs were anesthetized with isoflurane in oxygen. A target-controlled IV infusion device was used to administer ketamine and to achieve plasma ketamine concentrations of 0.5, 1, 2, 5, 8, and 11 μg/mL by use of parameters obtained from experiment 1. The MAC of isoflurane was determined at each plasma ketamine concentration, and blood samples were collected for ketamine and norketamine concentration determination. Results—Actual mean ± SD plasma ketamine concentrations were 1.07 ± 0.42 μg/mL, 1.62 ± 0.98 μg/mL, 3.32 ± 0.59 μg/mL, 4.92 ± 2.64 μg/mL, 13.03 ± 10.49 μg/mL, and 22.80 ± 25.56 μg/mL for target plasma concentrations of 0.5, 1, 2, 5, 8, and 11 μg/mL, respectively. At these plasma concentrations, isoflurane MAC was reduced by 10.89% to 39.48%, 26.77% to 43.74%, 25.24% to 84.89%, 44.34% to 78.16%, 69.62% to 92.31%, and 71.97% to 95.42%, respectively. The reduction in isoflurane MAC was significant, and the response had a linear and quadratic component. Salivation, regurgitation, mydriasis, increased body temperature, and spontaneous movements were some of the adverse effects associated with the high plasma ketamine concentrations. Conclusions and Clinical Relevance—Ketamine appears to have a potential role for balanced anesthesia in dogs. (Am J Vet Res 2006;67:21–25)

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American Journal of Veterinary Research

Tập 67 Số 1

21-25

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