Effect of intrauterine treatment with cephapirin on the reproductive performance of seasonally calving dairy cows at risk of endometritis following periparturient disease

Australian Veterinary Journal - Tập 86 Số 7 - Trang 250-258 - 2008
DJ Runciman1, GA Anderson2, J. Malmo1, G. M. Davis1
1Maffra Veterinary Centre, Maffra 3860
2University of Melbourne, Werribee 3030

Tóm tắt

Objective To determine the effect of intrauterine cephapirin (0.5 g) treatment on the reproductive performance of cows diagnosed as at risk of developing endometritis.Methods Cows (n = 1325) from 17 seasonal calving dairy herds were enrolled if they had been calved for more than 6 days and had a condition that placed them at risk of endometritis. Half were treated with intrauterine cephapirin at an examination performed 28–37 days prior to mating start date (MSD). Cows were scored for body condition, their vaginal discharge was scored using vaginoscopy (VV), and the uterus and ovaries were assessed by rectal palpation.Results Overall, there was no significant treatment effect on reproductive performance. In 945 modified at risk (MAR) cows the effect of treatment varied with the calving to treatment interval (CTI) and VV status. For the subset of 229 MAR cows with CTI ≤ 28 days, treatment improved the proportions of first‐service conception (OR 3.1; P < 0.01) and 6‐week in‐calf (OR 2.1; P < 0.05), and reduced the mean MSD to conception interval by 20 days (P < 0.05). The difference was greater in cows with a positive VV score (1–3). Treated VV‐negative cows with CTI > 48 days had a reduced proportion of cows in‐calf by 6 weeks (OR 0.58; P = 0.056) compared with untreated cows.Conclusion Intrauterine cephapirin infusion of MAR cows improved reproductive performance, depending on CTI. The greater treatment effect in VV‐positive cows suggests that VV scoring is a useful tool for the diagnosis of endometritis.

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Tài liệu tham khảo

10.2527/1992.70103158x

10.3168/jds.S0022-0302(02)74302-6

10.1111/j.1751-0813.2002.tb11007.x

CurtisMA LeanIJ.Path analysis of metabolic and antioxidant risk factors for periparturient and postparturient conditions and reproductive performance in dairy cows. In:Proceedings of the 20th World Buiatrics Congress Sydney July6–10 1998.

10.1016/S0093-691X(00)00311-3

10.1136/vr.142.21.575

Murray RD, 1990, Bovine endometritis: comparative efficacy of alfaprostol and intrauterine therapies, and other factors influencing clinical success, Vet Rec, 127, 86

10.1016/S0378-4320(00)00085-3

10.1016/0167-5877(94)00391-U

Thurmond MC, 1993, Effect of intrauterine antimicrobial treatment in reducing calving‐to‐conception interval in cows with endometritis, J Am Vet Med Assoc, 203, 1576, 10.2460/javma.1993.203.11.1576

10.3168/jds.S0022-0302(97)76024-7

Bondurant RH, 1999, Inflammation in the bovine female reproductive tract, J Dairy Sci, 82, 101

10.1016/0093-691X(86)90045-2

Smith BI, 2002, Clinical manifestations of postpartum metritis in dairy cattle, Comp Cont Ved Ed, 24, 56

10.1016/0093-691X(95)00123-P

Bonnett BN, 1991, Endometrial biopsy in Holstein‐Friesian dairy cows. III. Bacteriological analysis and correlations with histological findings, Can J Vet Res, 55, 168

10.3168/jds.S0022-0302(01)74644-9

10.1136/vr.128.19.440

10.1016/0093-691X(90)90522-U

DohmenMJW LohuisJACM.Bacteriology of endometritis in cows and its implications for successful treatment. In: 19th World Buiatrics Congress: Symposium – Endometritis: have we been missing something?Intervet Edinburgh 1996.

10.1136/vr.133.16.394

10.1016/0093-691X(94)90683-A

Heinonen M, 1989, Retained placenta in cattle: the effect of treatment or nontreatment on puerperal diseases and subsequent fertility, Acta Vet Scand, 30, 425, 10.1186/BF03548018

Smith BI, 2002, Predisposing factors and potential causes of postpartum metritis in dairy cattle, Comp Cont Ved Ed, 24, 74

10.1080/00480169.2001.36204

10.1016/S0167-5877(02)00016-8

10.1111/j.1751-0813.1995.tb03465.x

Morton J., 2000, The InCalf Project: Progress report No 2. A reference for advisers working with seasonal, split and batch calving herds

10.1111/j.1751-0813.2008.00301.x

10.1016/S0378-4320(00)00144-5

Singh B, 1997, Therapeutic trials on infertile cows, Indian Vet J, 74, 265

10.1016/S0378-4320(01)00124-5

CarnemollaG.Subacute/chronic endometritis: Evaluation of interuterine treatment with LydiumKLP Dimer in acetic acid solution. In:Proceedings of the 20th World Buiatrics Congress Sydney July6–10 1998.

10.3168/jds.S0022-0302(02)74303-8

10.1080/00480169.2001.36223

10.1136/vr.146.12.338

10.1136/vr.146.1.25

Putro PP, 1988, Effects of intrauterine dilute iodine solution infusion on the incidence of retained placenta and endometritis in dairy cows, Acta Vet Scand Suppl, 83, 58

10.1136/vr.120.3.53

10.1016/0093-691X(92)90042-P

10.1016/0093-691X(88)90277-4

10.1016/0093-691X(90)90823-C

Cohen RC, 1997, Sensitivity to antibiotics of bacteria isolated from uterine secretions of dairy cows with retained fetal membranes and post‐parturient metritis and concentrations of tetracyclines in uterine secretions after intrauterine administration, Isr J Vet Med, 52, 30

10.1016/0093-691X(95)00124-Q

10.1111/j.1439-0450.1996.tb00306.x

10.1016/j.theriogenology.2004.05.002

Robins C, 2003, The condition magician, 38

10.1002/0471722146

10.1109/TAC.1974.1100705

Hosmer DW, 1999, Applied survival analysis: regression modeling of time to event data

Cox DR, 1972, Regression models and life tables (with discussion), J R Stat Soc Ser B, 34, 187

Cleves MA, 2004, An introduction to survival analysis using stata

Dohoo I, 2003, Veterinary epidemiologic research

10.1002/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4

10.1111/j.0006-341X.2000.00645.x

ComptonC McDougallS.Induction and its role in dairy herd reproduction. In: Proceedings of the Society of Dairy Cattle Veterinarians of the New Zealand Veterinary Association.2006.

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Australian Veterinary Journal

Tập 86 Số 7

250-258

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