Effect of <i>N</i>-Alkyl and <i>N</i>-Alkenyl Substituents in Noroxymorphindole, 17-Substituted-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7:2‘,3‘-indolomorphinans, on Opioid Receptor Affinity, Selectivity, and Efficacy

Journal of Medicinal Chemistry - Tập 44 Số 9 - Trang 1471-1474 - 2001
Sherita McLamore1, Thomas Ullrich1, Richard B. Rothman1, Heng Xu1, Christina M. Dersch1, Andrew Coop1, Peg Davis1, Frank Porreca1, Arthur E. Jacobson1, Kenner C. Rice1
1Laboratory of Medicinal Chemistry, Building 8, Room B1-23, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0815, Clinical Psychopharmacology Section, National Institute on Drug Abuse, Addiction Research Center, Baltimore, Maryland 21224, and Department of Pharmacology, University of Arizona Health Science Center, Tucson, Arizona 85724

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