Effect of ethylnitrosourea and methyl methanesulfonate on mutation frequency in Muta™Mouse germ cells (seminiferous tubule cells and epididymis spermatozoa)

Ashby, J. (1995) Transgenic germ cell mutation assays: a small collaborative study, Environ. Mol. Mutagen., 25, 1–3. Beranek, D.T. (1990) Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents, Mutation Res., 231, 11–30. Callahan, J.D. and J.M. Short (1995) Transgenic λLacI mutagenicity assay: statistical determination of sample size, Mutation Res., 327, 201–208. Dean, S.W. and B. Myhr (1994) Measurement of gene mutation in vivo using Muta™Mouse and positive selection for LacZ− phage, Mutagenesis, 9, 183–185. Douglas, G.R., Gingerich, J.D., Gossen, J.A. and S.A. Bartlett (1994) Sequence spectra of spontaneous LacZ gene mutations in transgenic mouse somatic and germline tissues, Mutagenesis, 9, 451–458. Douglas, G.R., Jiao, J., Gingerich, J.D., Gossen, J.A. and L.M. Soper (1995) Temporal and molecular characteristics of mutations induced by ethylnitrosourea in germ cells isolated from seminiferous tubules and in spermatozoa of LacZ transgenic mice, Proc. Natl. Acad. Sci. USA, 92, 7485–7489. Dycaico, M.J., Provost, G.S., Kretz, P.L., Ransom, S.L., Moores, J.C. and J.M. Short (1994) The use of shuttle vectors for mutation analysis in transgenic mice and rats, Mutation Res., 307, 461–478. Ehling, U.H. and A. Neuhäuser-Klaus (1990) Induction of specific-locus and dominant lethal mutations in male mice in the low dose range by methyl methanesulfonate (MMS), Mutation Res., 230, 61–70. Evenson, D.P., Jost, L.K. and R.K. Baer (1993) Effects of methyl methanesulfonate on mouse sperm chromatin structure and testicular cell kinetics, Environ. Mol. Mutagen., 21, 144–153. Favor, J. (1993) Genetic effects from exposure to hazardous agents, Environ. Health Perspect., 101, (Suppl. 3) 263–267. Gossen, J.A., de Leeuw, W.J.F., Tan, C.H.T., Zarthoff, E.C., Berends, F., Lohman, P.H.M., Knook, D.L. and J. Vijg (1989) Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying in vivo, Proc. Natl. Acad. Sci. USA, 86, 7971–7975. Gossen, J.A., Molijn, A.C., Douglas, G.R. and J. Vijg (1992) Application of galactose-sensitive E. coli strains as selective hosts for LacZ− plasmids, Nucleic Acids Res., 20, 3254. Inoue, M., Kurihara, T., Yamashita, M. and K. Tatsumi (1993) Effects of treatment with methyl methanesulfonate during meiotic and postmeiotic stages and maturation of spermatozoa in mice, Mutation Res., 294, 179–186. Katoh, M., Inomata, T., Horiya, N., Suzuki, F., Shida, T., Ishioka, K. and T. Shibuya (1994) Studies on mutations in male germ cells of transgenic mice following exposure to isopropyl methanesulfonate, ethylnitrosourea or X-ray, Mutation Res., 341, 17–28. Kohler, S.W., Provost, G.S., Kretz, P.L., Dycaico, M.J., Sorge, J.A. and J.M. Short (1990) Development of a short-term, in vivo mutagenesis assay: the effects of methylation on the recovery of a lambda phage shuttle vector from transgenic mice, Nucleic Acids Res., 18, 3007–3012. Kohler, S.W., Provost, G.S., Fieck, A., Kretz, P.L., Bullock, W.O., Sorge, J.A., Putman, D.L. and J.M. Short (1991) Spectra of spontaneous and mutagen-induced mutations in the LacI gene in transgenic mice, Proc. Natl. Acad. Sci. USA, 88, 7958–7962. Lang, R. and I.D. Adler (1977) Heritable translocation test and dominant-lethal assay in male mice with methyl methanesulfonate, Mutation Res., 48, 75–88. Mientjes, E.J., Van Delft, J.H.M., Op 't Hof, B.M., Gossen, J.A., Vijg, J., Lohman, P.H.M. and R.A. Baan (1994) An improved selection method for λLacZ− phages based on galactose sensitivity, Transgenic Res., 3, 67–69. Meistrich, M.L., Reid, B.O. and W.J. Barcellona (1975) Meı̈otic DNA synthesis during mouse spermatogenesis, J. Cell. Biol., 64, 211–222. Mirsalis, J.C., Provost, G.S., Matthews, C.D., Hammer, R.T., Schindler, J.E., O'Loughlin, K.G., MacGregor, J.T. and J.M. Short (1993) Induction of hepatic mutations in LacI transgenic mice, Mutagenesis, 8, 265–271. Myhr, B.C. (1991) Validation studies with Muta™Mouse: a transgenic mouse model for detecting mutations in vivo, Environ. Mol. Mutagen. 18, 308–315. Provost, G.S. and J.M. Short (1994) Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice, Proc. Natl. Acad. Sci. USA, 91, 6564–6568. Provost, G.S., Rogers, B.J. and M.J. Dycaico (1995) Mutant frequency of spermatozoa isolated from the epididymis and vas deferens of transgenic C57BL/6 mice, Environ. Mol. Mutagen., 25 (Suppl. 25), 42. Oakberg, E.F. (1957) Duration of spermatogenesis in the mouse, Nature, 180, 1137–1138. Sega, G.A., Owens, J.G. and R.B. Cumming (1976) Studies on DNA repair in early spermatid stages of male mice after in vivo treatment with methyl-, ethyl-, propyl-, and isopropyl methanesulfonate, Mutation Res., 36, 193–212. Sega, G.A., Sluder, A.E., McCoy, L.S., Owens, J.G. and E.E. Generoso (1986) The use of alkaline elution procedures to measure DNA damage in spermiogenic stages of mice exposed to methyl methanesulfonate, Mutation Res., 159, 55–63. Shibuya, T. and K. Morimoto (1993) A review of the genotoxicity of 1-ethyl-1-nitrosourea, Mutation Res., 297, 3–38. Tao, K.S., Urlando, C. and J.A. Heddle (1993) Mutagenicity of methyl methanesulfonate (MMS) in vivo at the Dlb-1 native locus and a LacI transgene, Environ. Mol. Mutagen., 22, 293–296. Tinwell, H., Lefevre, P.A. and J. Ashby (1994) Response of the Muta™Mouse LacZ/galE− transgenic mutation assay to DMN: comparisons with the corresponding Big Blue™ (LacI) responses, Mutation Res., 307, 169–173. Van Delft, J.H.M. and R.A. Baan (1995) Germ cell mutagenesis in λLacZ transgenic mice treated with ethylnitrosourea; comparison with specific-locus test, Mutagenesis, 10, 209–214. Zenick, H., Clegg, E.D., Perreault, S.D., Klinefelter, G.R. and L.E. Gray (1994) Assessment of male reproductive toxicity: a risk assessment approach, in: A.W. Hayes (Ed.), Principles and Methods of Toxicology, Raven Press, New York, pp. 937–988.