Effect of cell surface deformation on synaptic factor accumulation during the early stages of T cell activation

Burack, 2002, Cutting edge: quantitative imaging of raft accumulation in the immunological synapse, J. Immunol., 169, 2837, 10.4049/jimmunol.169.6.2837 Carlsson, 1985, Kinetics of IL-2 and interferon-y production, expression of IL-2 receptors, and cell proliferation in human mononuclear cells exposed to straphylococcal enterotoxin A, Cell Immunol., 96, 175, 10.1016/0008-8749(85)90349-1 Demento, 2009, Biomimetric approaches to modulating the T cell immune response with nano- and micro- particles, Conf. Proc. IEEE Eng. Med. Biol. Soc., 2009, 1161 Dustin, 2000, The immunological synapse and the actin cytoskeleton:molecular hardware for T cell signaling, Nat. Immunol., 1, 23, 10.1038/76877 Dustin, 2006, Impact of the immunological synapse on T cell signaling, Results Probl. Cell, 43, 175, 10.1007/400_019 Dustin, 2005, A dynamic view of the immunological synapse, Semin. Immunol., 17, 175, 10.1016/j.smim.2005.09.002 Fahmy, 2001, Increased TCR avidity after T cell activation: a mechanism for sensing low density antigen, Immunity, 14, 135 Grakoui, 1999, The immunological synapse: a molecular machine controlling T cell activation, Science, 285, 221, 10.1126/science.285.5425.221 Hess, 1967, Calculation of potential flow about arbitrary bodies, Prog. Aeronaut. Sci., 8, 1, 10.1016/0376-0421(67)90003-6 Labowsky, 2012, Diffusive transfer between two intensely interacting cells with limited surface kinetics, Chem. Eng. Sci., 74, 114, 10.1016/j.ces.2012.02.001 Malek, 2008, The biology of interleukin-2, Annu. Rev. Immunol., 26, 453, 10.1146/annurev.immunol.26.021607.090357 Monks, 1998, Three-dimensional segregation of supramolecular activation clusters in T cells, Nature, 395, 82, 10.1038/25764 Pihlgren, 1996, Resting memory CD8+ T cells are hyperreactive to antigen challenge in vitro, J. Exp. Med., 184, 2141, 10.1084/jem.184.6.2141 Sabatos, 2008, A synaptic basis for paracrine Interleukin-2 signaling during homotypic T cell activation, Immunity, 29, 238, 10.1016/j.immuni.2008.05.017 Steenblock, 2008, A comprehensive platform for T cell stimulation based on biodegradable artificial antigen-presenting cell microparticles, Mol. Ther., 16, 765, 10.1038/mt.2008.11 Steenblock, 2009, Antigen presentation on artiificial acellular substrates: modular systems for flexible, adaptable immunotherapy, Expert Opin. Biol. Ther., 9, 451, 10.1517/14712590902849216 Steenblock, 2011, An artificial antigen-presenting cell with paracrine delivery of IL-2 impacts the magnitude and direction of the T cell response, J. Biol. Chem., 286, 34883, 10.1074/jbc.M111.276329