Effect of bisphenol-A (BPA) on placental biomarkers for inflammation, neurodevelopment and oxidative stress

Journal of Perinatal Medicine - Tập 47 Số 7 - Trang 741-749 - 2019
Yuko Arita1, Hyeon Jeong Park1, Aisling Cantillon1, Darios Getahun2, Ramkumar Menon3, Morgan R. Peltier1,4
1Department of Foundations of Medicine, NYU-Long Island School of Medicine , Mineola, NY , USA
2Department of Research and Evaluation , Kaiser-Permanente Southern California , Pasadena, CA , USA
3Department of Obstetrics and Gynecology, UTMB-Galveston, Galveston, TX, USA
4Department of Obstetric and Gynecology, NYU-Winthrop Hospital, 101 Mineola Blvd Rm. 4-040 , Mineola, NY , USA

Tóm tắt

Abstract Background Bisphenol-A (BPA) is a widespread pollutant whose effects on pregnant women are poorly understood. Therefore, we investigated the effects of BPA on basal and bacteria-stimulated production of proinflammatory cytokines [interleukin (IL)-1β, tumor necrosis factor-α (TNF-α) and IL-6], anti-inflammatory mediators [soluble glycoprotein 130 (sgp) 130, heme oxidase-1 (HO-1) and IL-10] and biomarkers for neurodevelopment [brain-derived neurotrophic factor (BDNF)], and oxidative stress [8-isoprostane (8-IsoP)] by the placenta. Methods Placental explant cultures were treated with BPA (0–10,000 nM) in the presence or absence of 107 colony-forming unit (CFU)/mL heat-killed Escherichia coli for 24 h. Biomarker concentrations in conditioned medium were quantified by the enzyme-linked immunosorbent assay (ELISA). Results Under basal conditions, IL-1β and IL-6 production was enhanced by BPA in a dose-dependent manner. Sgp130, a soluble receptor that reduces IL-6 bioactivity, was suppressed by BPA at 1000–10,000 nM. BPA also enhanced BDNF production at 1000 and 10,000 nM, and 8-IsoP expression at 10 and 100 nM. For bacteria-treated cultures, BPA increased IL-6 production at 100 nM and reduced sgp130 at 1000 nM but had no effect on IL-1β, TNF-α, BDNF, HO-1, 8-IsoP or IL-10 production. Conclusion BPA may increase placental inflammation by promoting IL-1β and IL-6 but inhibiting sgp130. It may also disrupt oxidative balance and neurodevelopment by increasing 8-IsoP and BDNF production.

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Journal of Perinatal Medicine

Tập 47 Số 7

741-749

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