Effect of acupuncture-moxibustion on TNF-α, sTNFR-I and sTNFR-II of rats with Crohn’s disease
Tóm tắt
To observe the effect of acupuncture-moxibustion on TNF-α, sTNFR-I and sTNFR-II in rats with Crohn’s disease (CD). The models of CD rats induced by TNBS were randomized into model group, herbal cake-partitioned moxibustion group and electroacupuncture group as well as a normal control group. The histopathological changes of colon mucus membrane were observed with HE staining and the contents of TNF-α, sTNFR-I and sTNFR-II were detected with ELISA method. When compared with the normal group, the TNF-α level in CD rats was substantially elevated and the sTNFR-I and sTNFR-II showed no marked changes. After herbal cake-partitioned moxibustion and electroacupuncture treatment, the TNF-α level in CD rats was substantially reduced and sTNFR-I and sTNFR-II showed no marked changes. The inflammatory lesions and abnormal structures of CD rats were significantly improved after herbal cake-partitioned moxibustion and electric stimulation. Herbal cake-partitioned moxibustion and electroacupuncture can both remarkably reduce the TNF-α level in blood serum, and this might be one of the action mechanisms in the treatment of CD.
Tài liệu tham khảo
WU Huan-gan, ZHANG Lin-shan. Clinical Study of Herbs-partition Moxibustion on Crohn’s Disease. Modern Rehabilitation, 2000, 4(3): 397.
Morris GP, Beck Pl, Herridge MS, et al. Hapten-induced Model of Chronic Inflammation and Ulceration in the Rat Colon. Gastroenterology,1989, 96(3): 95–811.
DENG Chang-sheng, XIA Bing. Inflammatory Bowel Diseases. Beijing: People’s Medical Publishing House, 1998: 123.
Colombel JF, Loftus EV Jr, Tremaine WJ, et al. The Safety Profile of Infliximab in Patients with Crohn’s Disease: the Mayo Clinic Experience in 500 Patients. Gastroenterology, 2004, 126(1):19–31.
Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance Infliximab for Crohn’s Disease: the ACCENT I Randomised Trial, Lancet, 2002, 359(9317):1541–1549.
Aliprantis AO, Diez-Roux G, Mulder LC, et al. Do Amacrophages Kill Though Apoptosis. Immunol Today, 1996, 17(12): 573–578.