Effect of Transcorneal Electrical Stimulation in Patients with Nonarteritic Ischemic Optic Neuropathy or Traumatic Optic Neuropathy

Japanese Journal of Ophthalmology - Tập 50 - Trang 266-273 - 2006
Takashi Fujikado1, Takeshi Morimoto1, Kenji Matsushita2, Hiroshi Shimojo2, Yoshitaka Okawa1, Yasuo Tano2
1Department of Applied Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan
2Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan

Tóm tắt

To determine whether transcorneal electrical stimulation (TES) can improve the visual function of patients with nonarteritic ischemic optic neuropathy (NAION) or traumatic optic neuropathy (TON). Eight consecutive patients at the Osaka University Hospital were studied. TES (600–800 µA, 20 Hz, 30 min) was applied once each to three eyes with NAION and to five eyes with TON, using a contact lens-type stimulating electrode. The primary outcome measurement was the change in visual acuity at 1 to 3 months after TES. An improvement in visual acuity was defined as a change of ≥0.3 log (minimum angle of resolution) (logMAR) units. The side effects of TES were also investigated. After TES application, the visual acuity improved in two patients with NAION and in four patients with TON. Visual acuity did not worsen in any of the eyes. Only a mild superficial punctuate keratopathy was observed in all eyes immediately after TES, and it healed by the next day. Visual acuity can be improved after TES without major complications in some patients with NAION or TON. These results suggest that TES should be considered as a new treatment for eyes with optic neuropathy. Jpn J Ophthalmol 2006;50:266–273 © Japanese Ophthalmological Society 2006

Tài liệu tham khảo

JD Trobe (2001) The neurology of vision Oxford University Press New York 215–218 InstitutionalAuthorNameThe Ischemic Optic Neuropathy Decompression Trial Research Group (2000) ArticleTitleIschemic optic neuropathy decompression trial. Twenty-four-month Update Arch Ophthalmol 118 793–798 AL Levin RW Beck MP Joseph S Seiff R Kraker InstitutionalAuthorNameand the International Optic Nerve Trauma Study Group (1999) ArticleTitleThe treatment of traumatic optic neuropathy Ophthalmology 106 1268–1277 Occurrence Handle10406604 Occurrence Handle1:STN:280:DyaK1MzjtlalsA%3D%3D Occurrence Handle10.1016/S0161-6420(99)00707-1 S Lessel (1999) ArticleTitleNonarteritic anterior ischemic optic neuropathy. Enigma variations Arch Ophthalmol 117 386–388 InstitutionalAuthorNameThe Ischemic Optic Neuropathy Decompression Trial Research Group (1995) ArticleTitleOptic nerve decompression surgery for nonarteritic anterior ischemic optic neuropathy (NAION) is not effective and may be harmful JAMA 273 625–632 Occurrence Handle10.1001/jama.273.8.625 LN Johnson ME Guy GB Krohel RW Madsen (2000) ArticleTitleLevodopa may improve vision loss in recent-onset, nonarteritic anterior ischemic optic neuropathy Ophthalmology 107 521–526 Occurrence Handle10711891 Occurrence Handle1:STN:280:DC%2BD3c7nsFSmtw%3D%3D Occurrence Handle10.1016/S0161-6420(99)00133-5 AG Lee PW Brazis (2003) Clinical pathways in neuro-ophthalmology. An evidence-based approach EditionNumber2nd ed. Thieme New York 82–83 JM Miller RA Altschuler (1995) ArticleTitleEffectiveness of different electrical stimulation conditions in preservation of spiral ganglion cells following deafness Ann Otol Rhinol Laryngol 166 57–60 Occurrence Handle1:STN:280:ByqA1MfjsVU%3D PA Leake GT Hradek RL Snyder (1999) ArticleTitleChronic electrical stimulation by a cochlear implant promotes survival of spiral ganglion neurons after neonatal deafness J Comp Neurol 412 543–562 Occurrence Handle10464355 Occurrence Handle1:STN:280:DyaK1MzpsFWktQ%3D%3D Occurrence Handle10.1002/(SICI)1096-9861(19991004)412:4<543::AID-CNE1>3.0.CO;2-3 AA Al-Majed TM Brushart T Gordon (2000) ArticleTitleElectrical stimulation accelerates and increases expression of BDNF and trkB mRNA in regenerating rat femoral motorneurons Eur J Neurosci 12 4381–4390 Occurrence Handle11122348 Occurrence Handle1:STN:280:DC%2BD3M7itValtg%3D%3D Occurrence Handle10.1046/j.1460-9568.2000.01341.x T Morimoto T Miyoshi T Fujikado Y Tano Y Fukuda (2002) ArticleTitleElectrical stimulation enhances the survival of axotomized retinal ganglion cells in vivo Neuroreport 13 227–230 Occurrence Handle11893915 Occurrence Handle10.1097/00001756-200202110-00011 AM Potts J Inoue (1968) ArticleTitleThe electrically evoked response of the visual system (EER) Invest Ophthalmol 7 269–278 Occurrence Handle5655874 Occurrence Handle1:STN:280:CCeB1c3ksFw%3D Y Miyake K Yanagida K Yagasaki (1980) ArticleTitleClinical application of EER (electrically evoked response). (1) Analysis of EER in normal subjects Nippon Ganka Gakkai Zasshi (Acta Soc Ophthalmol Jpn) 84 354–360 Occurrence Handle1:STN:280:Bi%2BB3sbhtVM%3D LN Johnson TJ Gould GB Krohel (1996) ArticleTitleEffect of levodopa and carbidopa on recovery of visual function in patients with nonarteritic anterior ischemic optic neuropathy of longer than six months' duration Am J Ophthalmol 121 77–83 Occurrence Handle8554083 Occurrence Handle1:CAS:528:DyaK28Xhtl2ktb4%3D JS Berestka JF Rizzo (1994) ArticleTitleControversy in the management of traumatic optic neuropathy Int Ophthalmol Clin 34 87–96 Occurrence Handle7960530 Occurrence Handle1:STN:280:ByqD2cbitVY%3D JL Franklin C Sanz-Rodriguez A Juhasz TL Deckwerth EM Johnson (1995) ArticleTitleChronic depolarization prevents programmed cell death of sympathetic neurons in vitro but does not support growth: requirement for CA2+ influx but not Trk activation J Neurosci 15 643–664 Occurrence Handle7823169 Occurrence Handle1:CAS:528:DyaK2MXjtFeqsL4%3D AL Miller DM Prieskorn RA Altschuler JM Miller (2003) ArticleTitleMechanism of electrical stimulation-induced neuroprotection: effects of verapamil on protection of primary auditory afferents Brain Res 966 218–230 Occurrence Handle12618345 Occurrence Handle1:CAS:528:DC%2BD3sXhs1ags7g%3D Occurrence Handle10.1016/S0006-8993(02)04170-7 T Morimoto T Miyoshi S Matsuda et al. (2005) ArticleTitleTranscorneal electrical stimulation rescues axotomized retinal ganglion cells by activating endogenous retinal IGF-1 system Invest Ophthalmol Vis Sci 46 2147–2155 Occurrence Handle15914636 Occurrence Handle10.1167/iovs.04-1339