Effect of Out-of-Hospital Tranexamic Acid vs Placebo on 6-Month Functional Neurologic Outcomes in Patients With Moderate or Severe Traumatic Brain Injury

JAMA - Journal of the American Medical Association - Tập 324 Số 10 - Trang 961 - 2020
Susan Rowell1,2, Eric N. Meier3, Barbara McKnight3, Delores Kannas3, Susanne May3, Kellie Sheehan3, Eileen M. Bulger4, Ahamed H. Idris5,6, Jim Christenson7,8, Laurie J. Morrison9, Nicolas Segal10, Patrick L. Bosarge11,12, M. Riccardo Colella13, Jay A. Johannigman14, Bryan A. Cotton15, Jeannie Callum16, Jason T. McMullan17, David J. Dries18, Brian Tibbs19, Neal J. Richmond20, Myron L. Weisfeldt21, John M. Tallon22,7, John S. Garrett23, Martin D. Zielinski24, Tom P. Aufderheide13, Rajesh R. Gandhi25, Rob Schlamp22, Bryce R. H. Robinson4, Jonathan Jui26, Lauren R. Klein27, Sandro Rizoli28, Mark Gamber29, Michael Fleming2, Jun Seong Hwang3, Laura Vincent15, Clifton W. Callaway11, Audrey Hendrickson27, Robert J Simonson30, Patricia Klotz4, George Sopko31, William R. Witham32, Michael J. Ferrara23, Martin A. Schreiber2
1Department of Surgery, Duke University School of Medicine, Durham, North Carolina
2Department of Surgery, Oregon Health & Science University, Portland
3Department of Biostatistics, University of Washington, Seattle
4Department of Surgery, University of Washington, Seattle
5Department of Emergency Medicine, University of Texas Southwestern Medical Center, Dallas
6Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.
7Department of Emergency Medicine, University of British Columbia, Vancouver, British Columbia, Canada
8Providence Health Care Research Institute, Vancouver, British Columbia, Canada
9Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
10Department of Emergency Medicine, Regions Hospital, St. Paul, Minnesota
11Department of Surgery, University of Alabama, Birmingham
12Department of Surgery, University of Arizona, Phoenix
13Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee
14Department of Surgery, University of Cincinnati, Cincinnati, Ohio
15Department of Surgery, McGovern Medical School, University of Texas Health Science Center, Houston
16Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada
17Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio
18Department of Surgery, Regions Hospital, St Paul, Minnesota
19Trauma Surgery, Texas Health Presbyterian Hospital, Dallas
20Department of Emergency Medicine, John Peter Smith Health Network, Ft Worth, Texas
21Johns Hopkins School of Medicine, Baltimore, Maryland
22British Columbia Emergency Health Services, Vancouver, British Columbia, Canada
23Department of Emergency Medicine, Baylor University Medical Center, Dallas, Texas
24Department of Surgery, Mayo Clinic, Rochester, Minnesota
25Department of Surgery, John Peter Smith Health Network, Ft Worth, Texas
26Department of Emergency Medicine, Oregon Health & Science University, Portland, Oregon
27Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, Minnesota
28Department of Surgery, St. Michael’s Hospital, Toronto, Ontario, Canada
29Department of Emergency Medicine, Medical City Plano, Plano, Texas
30Emergency Medicine, Methodist Dallas Medical Center, Dallas, Texas
31National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
32Trauma Surgery, Texas Health Harris Methodist Hospital, Ft Worth

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Tài liệu tham khảo

Feigin, 2019, Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016., Lancet Neurol, 18, 459, 10.1016/S1474-4422(18)30499-X

Alderson, 2005, Corticosteroids for acute traumatic brain injury., Cochrane Database Syst Rev

Lewis, 2017, Hypothermia for traumatic brain injury., Cochrane Database Syst Rev, 9

Ma, 2016, Progesterone for acute traumatic brain injury., Cochrane Database Syst Rev, 12

Kobayashi, 1966, The effect of a new potent antifibrinolytic agent, tranexamic acid., J Jpn Obstet Gynecol Soc, 13, 158

Gausden, 2017, Tranexamic acid in orthopaedic trauma surgery: a meta-analysis., J Orthop Trauma, 31, 513, 10.1097/BOT.0000000000000913

Pacheco, 2017, Tranexamic acid for the management of obstetric hemorrhage., Obstet Gynecol, 130, 765, 10.1097/AOG.0000000000002253

Shakur, 2010, Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial., Lancet, 376, 23, 10.1016/S0140-6736(10)60835-5

CRASH-3 trial collaborators, 2019, Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial., Lancet, 394, 1713, 10.1016/S0140-6736(19)32233-0

CRASH-2 Collaborators, 2011, Intracranial Bleeding Study C-2 C (Intracranial B. Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study)., BMJ, 343, d3795, 10.1136/bmj.d3795

Weng, 2019, Effect of tranexamic acid in patients with traumatic brain injury: a systematic review and meta-analysis., World Neurosurg, 123, 128, 10.1016/j.wneu.2018.11.214

Clifton, 1993, Relationship between Glasgow Outcome Scale and neuropsychological measures after brain injury., Neurosurgery, 33, 34

Shukla, 2011, Outcome measures for traumatic brain injury., Clin Neurol Neurosurg, 113, 435, 10.1016/j.clineuro.2011.02.013

Narayan, 2002, Clinical trials in head injury., J Neurotrauma, 19, 503, 10.1089/089771502753754037

van Buuren, 2007, Multiple imputation of discrete and continuous data by fully conditional specification., Stat Methods Med Res, 16, 219, 10.1177/0962280206074463

Wright, 2014, Very early administration of progesterone for acute traumatic brain injury., N Engl J Med, 371, 2457, 10.1056/NEJMoa1404304

Boudreau, 2019, Prehospital tranexamic acid administration during aeromedical transport after injury., J Surg Res, 233, 132, 10.1016/j.jss.2018.07.074

Murkin, 2010, High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients., Anesth Analg, 110, 350, 10.1213/ANE.0b013e3181c92b23

Keyl, 2011, High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement., Eur J Cardiothorac Surg, 39, e114, 10.1016/j.ejcts.2010.12.030

Lin, 2016, Tranexamic acid-associated seizures: a meta-analysis., Seizure, 36, 70, 10.1016/j.seizure.2016.02.011

Peterson, 2019, Surveillance Report of Traumatic Brain Injury-related Emergency Department Visits, Hospitalizations, and Deaths—United States, 2014

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JAMA - Journal of the American Medical Association

Tập 324 Số 10

961

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