Effect of OS-0544, a selective estrogen receptor modulator, on endothelial function and increased sympathetic activity in ovariectomized rats

Anderson, 2001, Effects of raloxifene and hormone replacement therapy on markers of serum atherogenicity in healthy postmenopausal women, Maturitas, 39, 71, 10.1016/S0378-5122(00)00224-3 Andrews, 1987, Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta, Nature, 327, 237, 10.1038/327237a0 Barrett-Connor, 1991, Estrogens and coronary heart disease in women, JAMA, 265, 1861, 10.1001/jama.265.14.1861 Barrett-Connor, 2002, Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trial, JAMA, 287, 847, 10.1001/jama.287.7.847 Barrett-Connor, 2006, Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women, N. Eng. J. Med., 355, 125, 10.1056/NEJMoa062462 Bassenge, 1991, Endothelium-mediated regulation of coronary tone, Basic Res. Cardiol., 86, 69 Bradbury, 2005, Tamoxifen-treated breast carcinoma patients and the risk of acute myocardial infarction and newly-diagnosed angina, Cancer., 103, 1114, 10.1002/cncr.20900 Celermajer, 1994, Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women, J. Am. Coll. Cardiol., 24, 471, 10.1016/0735-1097(94)90305-0 Chandrasekar, 2001, Coronary artery endothelial protection after local delivery of 17β-estradiol during balloon angioplasty in a porcine model: a potential new pharmacologic approach to improve endothelial function, J. Am. Coll. Cardiol., 38, 1570, 10.1016/S0735-1097(01)01552-2 Chao, 1979, Hepatic catabolism of rat and human lipoproteins in rats treated with 17α-ethinyl estradiol, J. Biol. Chem., 254, 11360, 10.1016/S0021-9258(19)86494-3 Colditz, 1986, A prospective study of parental history of myocardial infarction and coronary heart disease in women, Am. J. Epidemiol., 123, 48, 10.1093/oxfordjournals.aje.a114223 English, 1998, Effect of the menstrual cycle on endothelium-dependent vasodilation of the brachial artery in normal young women, Am. J. Cardiol., 15, 256 Freay, 1997, Mechanism of vascular smooth muscle relaxation by estrogen in depolarized rat and mouse aorta. Role of nuclear estrogen receptor and Ca2+ uptake, Circ. Res., 81, 242, 10.1161/01.RES.81.2.242 González-Pérez, 2004, Chronic effects of toremifene on the vasculature of menopause-induced rats, Vasc. Pharmacol., 40, 261, 10.1016/j.vph.2004.01.005 Hashimoto, 1995, Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle, Circulation, 92, 3431, 10.1161/01.CIR.92.12.3431 Hirai, 2000, Insulin resistance and endothelial dysfunction in smokers: effects of vitamin C, Am. J. Physiol. Heart Circ. Physiol., 279, H1172, 10.1152/ajpheart.2000.279.3.H1172 Huang, 1995, Hypertension in mice lacking the gene for endothelial nitric oxide synthase, Nature, 377, 239, 10.1038/377239a0 Ignarro, 1989, Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein, Circ. Res., 65, 1, 10.1161/01.RES.65.1.1 Kawano, 2005, Endothelial function and coronary spastic angina, Int. Med., 44, 91, 10.2169/internalmedicine.44.91 Kawano, 1996, Menstrual cyclic variation of endothelium-dependent vasodilation of the brachial artery: possible role of estrogen and nitric oxide, Proc. Assoc. Am. Physicians, 108, 473 Kawano, 2001, Estradiol supplementation suppresses hyperventilation-induced attacks in postmenopausal women with variant angina, J. Am. Coll. Cardiol., 37, 735, 10.1016/S0735-1097(00)01187-6 Kawano, 2001, Menstrual cyclic variation of myocardial ischemia in premenopausal women with variant angina, Ann. Intern. Med., 135, 977, 10.7326/0003-4819-135-11-200112040-00009 Keech, 2005, Year-by-year analysis of cardiovascular events in the Multiple Outcomes of Raloxifene Evaluation (MORE) trial, Curr. Med. Res. Opin., 21, 135, 10.1185/030079904X18045 Kharbanda, 2005, Systemic Acyl-CoA:cholesterol acyltransferase inhibition reduces inflammation and improves vascular function in hypercholesterolemia, Circulation, 111, 804, 10.1161/01.CIR.0000155236.25081.9B Kon, 2004, Effects of fenofibrate on lipoproteins, vasomotor function, and serological markers of inflammation, plaque stabilization, and hemostasis, Atherosclerosis, 174, 379, 10.1016/j.atherosclerosis.2004.01.033 Kugiyama, 1995, Increased constrictor response to acetylcholine of the isolated coronary arteries from patients with variant angina, Int. J. Cardiol., 52, 223, 10.1016/0167-5273(95)02478-6 Ma, 1986, Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17α-ethinyl estradiol, Proc. Natl. Acad. Sci. U. S. A., 83, 792, 10.1073/pnas.83.3.792 Mattar, 2008, Menopause, hormone therapy and cardiovascular and cerebrovascular disease, Ann. Acad. Med. Singap., 37, 54, 10.47102/annals-acadmedsg.V37N1p54 Nagai, 2003, Changes in autonomic activity and baroreflex sensitivity with the hypertension process and age in rats, Clin. Exp. Pharmacol. Physiol., 30, 419, 10.1046/j.1440-1681.2003.03852.x Pávó, 2000, Raloxifene, an oestrogen-receptor modulator, prevents decreased constitutive nitric oxide and vasoconstriction in ovariectomized rats, Eur. J. Pharmacol., 410, 101, 10.1016/S0014-2999(00)00865-7 Rossouw, 2002, Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial, JAMA, 288, 321, 10.1001/jama.288.3.321 Saleh, 2000, Autonomic and cardiovascular reflex response to central estrogen injection in ovariectomized female rats, Brain Res., 879, 105, 10.1016/S0006-8993(00)02757-8 Shimokawa, 2000, Cellular and molecular mechanisms of coronary artery spasm, Jpn. Circ. J., 64, 1, 10.1253/jcj.64.1 Squadrito, 2000, Genistein supplementation and estrogen replacement therapy improve endothelial dysfunction induced by ovariectomy in rats, Cardiovasc. Res., 45, 454, 10.1016/S0008-6363(99)00359-4 Steinberg, 1996, Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance, J. Clin. Invest., 97, 2601, 10.1172/JCI118709 Sueda, 1999, Frequency of provoked coronary vasospasm in patients undergoing coronary arteriography with spasm provocation test of acetylcholine, Am. J. Cardiol., 83, 1186, 10.1016/S0002-9149(99)00057-0 Tamai, 1997, Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans, Circulation, 95, 76, 10.1161/01.CIR.95.1.76 Tan, 2003, Wavelet transform analysis of heart rate variability to assess the autonomic changes associated with spontaneous coronary spasm of variant angina, J. Electrocardiol., 36, 117, 10.1054/jelc.2003.50022 Tesfamariam, 1992, Free radicals mediate endothelial cell dysfunction caused by elevated glucose, Am. J. Physiol., 263, H321 Vongpatanasin, 2001, Transdermal estrogen replacement therapy decreases sympathetic activity in postmenopausal women, Circulation, 103, 2903, 10.1161/01.CIR.103.24.2903 Walsh, 1991, Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins, N. Engl. J. Med., 325, 1196, 10.1056/NEJM199110243251702 Watanabe, 2003, Discovery and preclinical characterization of (+)-3-[4-(1-piperidinoethoxy)phenyl]spiro[indene-1,1′-indane]-5,5′-diol hydrochloride: a promising nonsteroidal estrogen receptor agonist for hot flush, J. Med. Chem., 46, 3961, 10.1021/jm034134+ Weitz, 2001, Postmenopausal estrogen administration suppresses muscle sympathetic nerve activity, J. Clin. Endocrinol. Metab., 86, 344, 10.1210/jc.86.1.344 Xu, 2007, Effects of ovariectomy and 17beta-estradiol treatment on the renin–angiotensin system, blood pressure, and endothelial ultrastructure, Int. J. Cardiol., 14 Yasue, 1974, Role of autonomic nervous system in the pathogenesis of Prinzmetal's variant form of angina, Circulation, 50, 534, 10.1161/01.CIR.50.3.534 Yasue, 1986, Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm, Circulation, 74, 955, 10.1161/01.CIR.74.5.955 Zoubina, 2001, Sympathetic hyperinnervation of the uterus in the estrogen receptor alpha knock-out mouse, Neuroscience, 103, 237, 10.1016/S0306-4522(00)00549-2