Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration

Grassi C, Morandini GC (1976) A controlled trial of intermittent oral acetylcysteine in long-term treatment of chronic bronchitis. Eur J Clin Pharmacol 9: 393–396

Mitchell EA, Elliott RB (1982) Controlled trial of oral N-acetylcysteine in cystic fibrosis. Aust Paediatr J 18: 40–42

Morgan LR, Holdiness MR, Gillen LE (1983) N-acetylcysteine: Its bioavailability and interaction with ifosfamide metabolites. Semin Oncol 10 [Suppl 1]: 56–61

Prescott LF, Ballantyne A, Park J, Adriaenssens P, Proudfoot AT (1977) Treatment of paracetamol (acetaminophen) poisoning with N-acetyl-cysteine. Lancet 2: 432–434

Lauterburg BH, Corcoran GB, Mitchell JR (1983) Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest 71: 980–991

Corcoran GB, Wong BK (1986) Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: Studies with N-acetyl-D-cysteine. J Pharmacol Exp Ther 238: 54–61

Olsson B, Johansson M, Gabrielsson J, Bolme P (1988) Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine. Eur J Clin Pharmacol 34: 77–82

Cotgreave IA, Moldeus P (1987) Methodologies for the analysis of reduced and oxidized N-acetylcysteine in biological systems. Biopharm Drug Dispos 8: 365–375

Borgstroem L, Kagedal B, Paulsen O (1986) Pharmacokinetics of N-acetylcysteine in man. Eur J Clin Pharmacol 31: 217–222

Lauterburg BH, Mitchell JR (1987) Therapeutic doses of acetaminophen stimulate the turnover of cysteine and glutathione in man. J Hepatol 4: 206–211

Newton GL, Dorian R, Fahey RC (1981) Analysis of biological thiols: Derivatization with monobromobimane and separation by reverse-phase high-performance liquid chromatography. Anal Biochem 114: 383–387

Kagedal B, Kallberg M, Martensson J (1984) Determination of non-protein-bound N-acetylcysteine in plasma by high-performance liquid chromatography. J Chromatogr 311: 170–175

Aw TY, Ookhtens M, Kaplowitz N (1986) Mechanism of inhibition of glutathione efflux by methionine from isolated rat hepatocytes. Am J Physiol 251: G354-G361

Reed DJ, Beatty PW (1978) The role of the cystathionine pathway in glutathione regulation by isolated hepatocytes. In: Sies H, Wendel A (eds) Functions of glutathione in liver and kidney; Springer, Heidelberg Berlin New York, pp 13–21

Adams JD, Lauterburg BH, Mitchell JR (1983) Plasma glutathione and glutathione disulfide in the rat: Regulation and response to oxidative stress. J Pharmacol Exp Ther 227: 749–754

Lauterburg BH, Velez ME, Mitchell JR (1984) Plasma glutathione as an index of intrahepatic GSH in man: Response to acetaminophen and chronic ethanol abuse. Hepatology 4: 1051 (abstract)