Effect of In Utero Exposure of Gabapentin and Valproic Acid on Skeletal Anomalies in Rat Fetuses
Tóm tắt
For treatment of epileptic seizures, classical and novel antiepileptic drugs (AEDs) are available for general population and also recommended to pregnant women with caution considering their teratogenic risks. Literature indicates that skeletal teratogenic safety of novel or atypical AEDs has not been well documented so far as established for classical AEDs. Reports on fetal skeletal anomalies caused by in utero exposure of gabapentin (GBP) are less and inconclusive. Therefore, present study has been undertaken to compare the skeletal safety of GBP and valproic acid (VPA, a classical drug) in non-epileptic pregnant rats using equivalent therapeutic doses. The present study concludes that maternal exposure of GBP or VPA may adversely affect the development and growth of skeletal system in rat fetuses but skeletal anomalies were found more intense in VPA than GBP. The involvement of multifactorial inducing mechanisms, from environmental to molecular, are expected for variable skeletal birth defects. Therefore, extrapolation of animal data to clinics should be critically scrutinized before drug (GBP) recommendation to pregnant women population.
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