Effect of Feixian Recipe on laminin, collagen I and III in rats with pulmonary fibrosis induced by bleomycin
Tóm tắt
The aim of this paper is to observe the effect of the Feixian Recipe on pulmonary fibrosis in rats. A rat model with pulmonary fibrosis was established by intratracheal injection of bleomycin. On days 14, 28 and 45, the contents of laminin, collagen I and collagen III in lung tissue homogenate in the model group, the sham operated group, the Feixian group and the prednisone group were measured. The contents of laminin and collagen I and III were decreased significantly by the Feixian Recipe. Feixian Recipe has a significant therapeutic effect on bleomycin-induced pulmonary fibrosis in rats.
Tài liệu tham khảo
Phan S H. Role of the LN in pulmonary fibrosis. Kidney Int, 1996, 49(Supple 54): S46–S48
Ramos C, Montaño M, García-Alvarez J, Ruiz V, Uhal B D, Selman M, Pardo A. Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression. Am J Respir Cell Mol Biol, 2001, 24(5): 591–598
Ghosh A K. Factors involved in the regulation of type I collagen gene expression: implication in fibrosis. Exp Biol Med (Maywood), 2002, 227(5): 301–314
Lu X Y, Lu CH, Zhang G Z H, Hua Y Q, Zheng X P. Expression of type III collagen in bleomycin-induced pulmonary fibrosis. Shanghai Yixue, 2002, 25(4): 205–206 (in Chinese)
He X H, Zhang L, Wang X H. The advancement in researching of collagen and pulmonary interstitial fibrosis. Huabei Meitan Yixueyuan Xuebao, 2005, 7(1): 43–45 (in Chinese)