Effect of Diet and Exercise, Alone or Combined, on Weight and Body Composition in Overweight‐to‐Obese Postmenopausal Women

Obesity - Tập 20 Số 8 - Trang 1628-1638 - 2012
Karen E. Foster‐Schubert1,2, Catherine M. Alfano3, Catherine Duggan1, Liren Xiao1, Kristin L. Campbell4, Angela Kong1, Carolyn Bain1, Ching‐Yun Wang1,2, George L. Blackburn5, Anne McTiernan1,2
1Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
2University of Washington School of Medicine, Seattle, Washington (USA)
3Office of Cancer Survivorship, National Cancer Institute, Bethesda, Maryland, USA
4University of British Columbia, Vancouver, British Columbia, Canada
5Harvard Medical School Boston Massachusetts USA

Tóm tắt

Lifestyle interventions for weight loss are the cornerstone of obesity therapy, yet their optimal design is debated. This is particularly true for postmenopausal women; a population with a high prevalence of obesity yet toward whom fewer studies are targeted. We conducted a year‐long, 4‐arm randomized trial among 439 overweight‐to‐obese postmenopausal sedentary women to determine the effects of a calorie‐reduced, low‐fat diet (D), a moderate‐intensity, facility‐based aerobic exercise program (E), or the combination of both interventions (D+E), vs. a no‐lifestyle‐change control (C) on change in body weight and composition. The group‐based dietary intervention had a weight‐reduction goal of ≥10%, and the exercise intervention consisted of a gradual escalation to 45‐min aerobic exercise 5 day/week. Participants were predominantly non‐Hispanic whites (85%) with a mean age of 58.0 ± 5.0 years, a mean BMI of 30.9 ± 4.0 kg/m2 and an average of 47.8 ± 4.4% body fat. Baseline and 12‐month weight and adiposity measures were obtained by staff blinded to participants' intervention assignment. Three hundred and ninety nine women completed the trial (91% retention). Using an intention‐to‐treat analysis, average weight loss at 12 months was −8.5% for the D group (P < 0.0001 vs. C), −2.4% for the E group (P = 0.03 vs. C), and −10.8% for the D+E group (P < 0.0001 vs. C), whereas the C group experienced a nonsignificant −0.8% decrease. BMI, waist circumference, and % body fat were also similarly reduced. Among postmenopausal women, lifestyle‐change involving diet, exercise, or both combined over 1 year improves body weight and adiposity, with the greatest change arising from the combined intervention.

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Obesity

Tập 20 Số 8

1628-1638

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