Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19

JAMA - Journal of the American Medical Association - Tập 324 Số 13 - Trang 1307 - 2020
Bruno Martins Tomazini1,2, Israel Silva Maia3,4, Alexandre Biasi Cavalcanti3,4, Otávio Berwanger5, Régis Goulart Rosa3,6, Viviane Cordeiro Veiga7,3, Álvaro Avezum8, Renato D. Lópes9, Flávia Regina Bueno2, Maria Vitoria A. O. Silva2, Franca Pellison Baldassare2, Eduardo Leite Vieira Costa2,10, Ricardo Antonio Bonifácio Moura2, Michele Ouriques Honorato2, André Nathan Costa11,2, Lucas Petri Damiani4, Thiago Lisboa3,12, Letícia Kawano-Dourado4, Fernando G. Zampieri3,4, Guilherme Benfatti Olivato5,13, Cassiano Teixeira14,15, Cristina Prata Amêndola16, Roberta Muriel Longo Roepke1,17, Daniela Helena Machado de Freitas10, Daniel Neves Forte2,18, Flávio Geraldo Rezende Freitas19,3, Caio César Ferreira Fernandes20, Lívia Maria Garcia Melro21, F. S. Gedealvares22, Douglas Costa Morais23, Stevin Zung23, F.S. Machado19,3, Luciano César Pontes Azevedo3,24,2
1Departamento de Cirurgia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
2Hospital Sírio-Libanês, São Paulo, Brazil
3Brazilian Research in Intensive Care Network (BRICNet), São Paulo, Brazil
4HCor Research Institute, São Paulo, Brazil
5Academic Research Organization, Hospital Israelita Albert Einstein, São Paulo, Brazil
6Hospital Moinhos de Vento, Porto Alegre, Brazil
7BP– A Beneficência Portuguesa de São Paulo, São Paulo, Brazil
8International Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil
9Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina
10UTI Respiratória, Instituto do Coração (Incor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
11Departamento de Cardiopneumologia, Instituto do Coração (Incor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
12Hospital de Clinicas de Porto Alegre, Rio Grande do Sul, Brazil
13Hospital Vila Santa Catarina, São Paulo, Brazil
14Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil
15Laboratorio de Medicina Intensiva, Instituto Nacional de Infectologia, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil
16Barretos Cancer Hospital, Barretos, Brazil
17Intensive Care Unit, AC Camargo Cancer Center, São Paulo, Brazil
18UTI 09DN, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
19Anesthesiology, Pain and Intensive Care Department, Federal University of São Paulo, São Paulo, Brazil
20Hospital Mario Covas, FMABC, Santo Andre, Brazil
21Hospital Samaritano Paulista, São Paulo, Brazil
22Hospital Evangélico de Vila Velha, Vila Velha, Brazil
23Aché Laboratórios Farmacêuticos, São Paulo, Brazil
24Disciplina de Emergências Clínicas, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

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