Editors’ Pick: What a pain…, or not!

Cox JJ, Reimann F, Nicholas AK, Thornton G, Roberts E, Springell K, Karbani G, Jafri H, Mannan J, Raashid Y, Al-Gazali L, Hamamy H, Valente EM, Gorman S, Williams R, McHale DP, Wood JN, Gribble FM, Woods CG: An SCN9A channelopathy causes congenital inability to experience pain. Nature. 2006, 444: 894-898. 10.1038/nature05413. Leipold E, Liebmann L, Korenke GC, Heinrich T, Giesselmann S, Baets J, Ebbinghaus M, Goral RO, Stödberg T, Hennings JC, Bergmann M, Altmüller J, Thiele H, Wetzel A, Nürnberg P, Timmerman V, De Jonghe P, Blum R, Schaible HG, Weis J, Heinemann SH, Hübner CA, Kurth I: A de novo gain-of-function mutation in SCN11A causes loss of pain perception. Nature Genetics. 2013, 45 (11): 1399-1404. 10.1038/ng.2767. Cox JJ, Wood JN: No pain, more gain. Nature Genetics. 2013, 45 (11): 1271-1272. 10.1038/ng.2810.