Ecotoxicology and innate immunity in fish

Connell, 1999

Sindermann, 1979, Pollution-associated diseases and abnormalities of fish and shellfish: a review, Fish Bull, 76, 717

Snieszko, 1974, The effects of environmental stress on outbreaks of infectious diseases of fishes, J Fish Biol, 6, 197, 10.1111/j.1095-8649.1974.tb04537.x

Meador, 1995, Bioaccumulation of polycyclic aromatic hydrocarbons by marine organisms, Rev Env Contamin Toxicol, 143, 79

Safe, 1994, Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment, Crit Rev Toxicol, 24, 87, 10.3109/10408449409049308

Mukerjee, 1998, Health impact of polychlorinated dibenzo-p-dioxins: a critical review, J Air Waste Manage Assoc, 48, 157, 10.1080/10473289.1998.10463655

O'Halloran, 1998, The adverse effect of aquatic contaminants on fish immune responses, Australasian J Ecotoxicol, 4, 9

Zelikoff, 1993, Metal pollution-induced immunomodulation in fish, Ann Rev Fish Diseases, 2, 305, 10.1016/0959-8030(93)90041-9

Sandbacka, 2000, The acute toxicity of surfactants on fish cells, Daphnia magna and fish—a comparative study, Toxicol Vitr, 14, 61, 10.1016/S0887-2333(99)00083-1

O'Halloran, 1998, Response of fish immune cells to in vitro organotin exposures, Aquatic Toxicol, 40, 141, 10.1016/S0166-445X(97)00054-4

Dunier, 1993, Effects of pesticides and other organic pollutants in the aquatic environment on immunity of fish: a review, Fish Shellfish Immunol, 3, 423, 10.1006/fsim.1993.1042

Hoffmann, 1999, Phylogenetic perspectives in innate immunity, Science, 284, 1313, 10.1126/science.284.5418.1313

Ulevitch, 2000, Molecular mechanisms of innate immunity, Immunol Res, 21, 49, 10.1385/IR:21:2-3:49

Shugart, 1992, Biological markers of environmental and ecological contamination, Risk Anal, 12, 353, 10.1111/j.1539-6924.1992.tb00687.x

Dary CC, Quackenboss JJ, Nauman CH, Hern SC. Relationship of biomarkers of exposure to risk assessment and risk management. In: Blancato JN, Brown RN, Dary CC, Saleh MA, editors. Biomarkers for agrochemicals and toxic substances. Washington DC: American Chemical Society, 1994. p. 226–47.

Wester, 1994, Fish biomarkers in immunotoxicology, Toxicology, 86, 213, 10.1016/0300-483X(94)90005-1

Alexander, 1992, Noncellular nonspecific defence mechanisms of fish, Ann Rev Fish Dis, 2, 249, 10.1016/0959-8030(92)90066-7

Zelikoff, 2000, Biomarkers of immunotoxicity in fish: from the lab to the ocean, Toxicol Lett, 112/113, 325, 10.1016/S0378-4274(99)00202-7

Zelikoff, 1998, Biomarkers of immunotoxicity in fish and other non-mammalian sentinel species: predictive value for mammals?, Toxicology, 129, 63, 10.1016/S0300-483X(98)00064-X

Adams, 1999, Establishing possible links between aquatic ecosystem health and human health: an integrated approach, 91

Fearon, 1996, The instructive role of innate immunity in the acquired immune response, Science, 272, 50, 10.1126/science.272.5258.50

Anderson, 1995, Immunotoxicology in fish, vol. 2, 371

Anderson, 1996, Environmental factors in fish health: immunological aspects, 289

Zeeman, 1981, Effects of toxic agents upon fish immune systems: a review, vol. II, 1

Zelikoff, 1944, Fish immunotoxiclogy, 71

Anderson, 1993, Modulation of nonspecific immunity by environmental stressors, 483

Fletcher, 1986, Modulation of nonspecific host defenses in fish, Vet Immunol Immunopathol, 12, 59, 10.1016/0165-2427(86)90110-8

Ellis, 1981, Non-specific defense mechanisms in fish and their role in disease processes, Develop Biol Standard, 49, 337

Shephard, 1994, Functions for fish mucus, Rev Fish Biol Fisheries, 4, 401, 10.1007/BF00042888

Campos-Perez, 2000, The gills are an important site of iNOS expression in rainbow trout Oncorhynchus mykiss after challenge with the Gram-positive pathogen Renibacterium salmoninarum, Immunol, 99, 153, 10.1046/j.1365-2567.2000.00914.x

Ebran, 1999, Pore-forming properties and antibacterial activity of proteins extracted from epidermal mucus of fish, Comp Biochem Physiol A, 122, 181, 10.1016/S1095-6433(98)10165-4

Evelyn, 1996, Infection and disease, 339

Lock, 1981, Effects of mercuric chloride and methylmercuric chloride on mucus secretion in rainbow trout, Salmo gairdneri Richardson, Comp Biochem Physiol C, 69C, 67, 10.1016/0306-4492(81)90103-9

Richmonds, 1989, Histopathological changes induced by malathion in the gills of blue gill Lepomis macrochirus, Bull Environ Contam Toxicol, 43, 123, 10.1007/BF01702248

Pfeiffer, 1997, Electron microscopic perspectives of gill pathology induced by 1-naphthyl-N-methylcarbamate in the goldfish (Carassius auratus Linnaeus), Histol Histopathol, 12, 645

Brenniman, 1979, Effects of outboard motor exhaust emissions on goldfish (Carassius auratus), J Environ Pathol Toxicol, 2, 1267

Mallatt, 1985, Fish gill structural changes induced by toxicants and other irritants: a statistical review, Can J Fish Aquat Sci, 42, 630, 10.1139/f85-083

Roy, 1988, Statistical analysis of anionic detergent-induced changes in the goblet mucous cells of opercular epidermis and gill epithelium of Rita rita (Ham.) (Bagridae: Pisces), Ecotoxicol Environ Saf, 15, 260, 10.1016/0147-6513(88)90080-2

Sovenyi, 1993, Studies on the toxic and immunosuppressive effects of cadmium on the common carp, Acta Vet Hung, 41, 415

Khan, 1984, Histopathological effects of crude oil on Atlantic cod following chronic exposure, Can J Zool, 62, 2038, 10.1139/z84-298

Lichtenfels, 1996, Effects of water pollution on the gill apparatus of fish, J Comp Pathol, 115, 47, 10.1016/S0021-9975(96)80027-2

Arillo, 1984, Biochemical effects of long-term exposure to cadmium and copper on rainbow trout (Salmo gairdneri): validation of water quality criteria, Ecotoxicol Environ Saf, 8, 106, 10.1016/0147-6513(84)90054-X

Khan, 1991, Influence of pollution on parasites of aquatic animals, Adv Parisitol, 30, 201, 10.1016/S0065-308X(08)60309-7

Eller, 1975, Gill lesions in freshwater teleosts, 305

Evans, 1987, The fish gill: site of action and model for toxic effects of environmental pollutants, Env Hlth Persp, 71, 47, 10.1289/ehp.877147

Grinwis, 2000, Toxicology of environmental chemicals in the flounder (Platichthys flesus) with emphasis on the immune system: field, semi-field (mesocosm) and laboratory studies, Toxicol Lett, 112-113, 289, 10.1016/S0378-4274(99)00239-8

Schirmer, 1997, Methodology for demonstrating and measuring the photocytotoxicity of fluoranthene to fish cells in culture, Toxicol Vitr, 11, 107, 10.1016/S0887-2333(97)00002-7

Schirmer, 1998, Ability of 16 priority PAHs to be photocytotoxic to a cell line from the rainbow trout gill, Toxicology, 127, 143, 10.1016/S0300-483X(98)00031-6

Schirmer, 1999, Use of fish gill cells in culture to evaluate the cytotoxicity and photocytoxicity of intact and photomodified creosote, Environ Toxicol Chem, 18, 1277, 10.1002/etc.5620180630

Bowers, 1981, Hyperosmotic infiltration: immunological demonstration of infiltrating bacteria in brown trout, Salmo trutta L, J Fish Biol, 18, 9, 10.1111/j.1095-8649.1981.tb03754.x

Iger, 1994, Effects of water-borne cadmium on the skin of the common carp (Cyprinus carpio), Arch Environ Contam Toxicology, 26, 342, 10.1007/BF00203561

Khangarot, 1991, Changes in humoral and cell-mediated responses and in skin and respiratory surfaces of catfish, Saccobranchus fossilis, following copper exposure, Ecotoxicol Env Safety, 22, 291, 10.1016/0147-6513(91)90080-9

McKone, 1971, Rapid uptake of mercuric ion by goldfish, Environ Sci Technol, 5, 1138, 10.1021/es60058a011

Rajan, 1991, Histopathological changes induced by acute toxicity of mercuric chloride on the epidermis of freshwater catfish—Heteropneustes fossilis (Bloch), Ecotoxicol Environ Saf, 22, 139, 10.1016/0147-6513(91)90054-S

Varanasi, 1975, Structural alterations in fish epidermal mucus produced by water-borne lead and mercury, Nature, 258, 431, 10.1038/258431a0

Fletcher, 1981, Non anti-body molecules and the defence mechanisms of fish, 171

Bordas, 1996, Kinetcs of adhesion of selected fish-pathogenic Vibrio strains of skin mucus of gilt-head sea bream (Sparus aurata L.), Appl Environ Microbiol, 62, 3650, 10.1128/AEM.62.10.3650-3654.1996

Burkhardt-Holm, 2000, Nonylphenol affects the granulation pattern of epidermal mucous cells in rainbow trout, Oncorhynchus mykiss, Ecotoxicol Environ Saf, 46, 34, 10.1006/eesa.1999.1871

Zaccone, 1985, The effect of an anionic detergent on complex carbohydrates and enzyme activities in the epidermis of the catfish Heteropneustes fossilis (Bloch), Histochem J, 17, 453, 10.1007/BF01003205

Garg, 1993, Observations on the function of mucous cells in the epidermis of the cat-fish Clarias batrachus exposed to sodium dodecyl sulfate, Biomed Environ Sci, 6, 119

Benedetti, 1989, Histomorphological changes in some organs of the brown bullhead, Ictalurus nebulosus LeSueur, following short-and long-term exposure to copper, J Fish Biol, 34, 273, 10.1111/j.1095-8649.1989.tb03308.x

Khan, 1994, Histopathology in winter flounder (Pleuronectes americanus) living adjacent to a pulp and paper mill, Arch Environ Contam Toxicol, 26, 95, 10.1007/BF00212799

Burkhardt-Holm, 1997, Waste-water management plant effluents cause cellular alterations in the skin of brown trout, J Fish Biol, 50, 744, 10.1111/j.1095-8649.1997.tb01969.x

Iger, 1988, Cellular responses in the skin of carp maintained in organically fertilized water, J Fish Biol, 33, 711, 10.1111/j.1095-8649.1988.tb05516.x

Murad, 1988, Leucocytes and leucopoietic capacity in goldfish, Carassius auratus, exposed to sublethal levels of cadmium, Aquat Toxicol, 13, 141, 10.1016/0166-445X(88)90039-2

Bucke, 1983, A histopathological report of some epidermal anomalies of Dover sole, Solea solea L., and other flatfish species in coastal waters off south east England, J Fish Biol, 23, 565, 10.1111/j.1095-8649.1983.tb02936.x

Lee, 1997, Development of a cell line from skin of goldfish, Carassius auratus, and effects of ascorbic acid on collagen deposition, Histochem J, 29, 31, 10.1023/A:1026412817431

Saito, 1991, In vitro cytotoxicity of chlorophenols to goldfish GF-scale (GFS) cells and quantitative structure–activity relationships, Environ Toxicol Chem, 10, 235, 10.1002/etc.5620100212

Sigel, 1986, Phylogenetic studies of lymphokines. Fish lymphocytes respond to human IL-1 and epithelial cells produce an IL-1 like factor, Vet Immunol Immunopathol, 12, 47, 10.1016/0165-2427(86)90109-1

Lamache, 1998, Primary cultures of dispersed skin epidermal cells of rainbow trout Oncorhynchus mykis Walbum, Cell Mol Life Sci, 54, 1042, 10.1007/s000180050231

Mothersill, 1995, Growth and differentiation of epidermal cells from the rainbow trout established as explants and maintained in various media, J Fish Biol, 46, 1011, 10.1111/j.1095-8649.1995.tb01406.x

Dowling, 1999, Use of rainbow trout primary epidermal cell cultures as an alternative to immortalized cell lines in toxicity assessment: a study with nonoxynol, Environ Toxicol Chem, 18, 2846, 10.1002/etc.5620181227

Yano, 1996, The nonspecific immune system: humoral defense, 106

Kozinenko, 1999, Humoral factors of nonspecific defense in fish, J Ichthyol, 39, 394

Sanchez-Dardon, 1999, Immunomodulation by heavy metals tested individually or in mixtures in rainbow trout (Oncorhynchus mykiss) exposed in vivo, Environ Toxicol Chem, 18, 1492, 10.1897/1551-5028(1999)018<1492:IBHMTI>2.3.CO;2

Low, 1998, Effects of mercuric chloride and sodium selenite on some immune responses of blue gourami, Trichogaster trichopterus (Pallus), Sci Total Environ, 214, 153, 10.1016/S0048-9697(98)00061-8

Zelikoff, 1995, Immunotoxicity of low level cadmium exposure in fish: an alternative animal model for immunotoxicological studies, J Toxicol Environ Health, 45, 235, 10.1080/15287399509531993

Siwicki, 1990, In vivo effect of the organophosphorus insecticide trichlorphon on immune response of carp (Cyprinus carpio). II. Effect of high doses of trichlorophon on nonspecific immune response, Ecotoxicol Environ Saf, 19, 99, 10.1016/0147-6513(90)90084-I

Dunier, 1991, Effects of organophosphorus insecticides: effects of trichlorfon and dichlorvos on the immune response of carp (Cyprinus carpio). III. In vitro effects on lymphocyte proliferation and phagocytosis and in vivo effects on humoral response, Ecotoxicol Environ Saf, 22, 79, 10.1016/0147-6513(91)90049-U

Tahir, 1995, The effects of diesel oil-based drilling mud extracts on immune responses of rainbow trout, Arch Environ Contam Toxicol, 29, 27, 10.1007/BF00213083

Tahir, 1993, Effect of short-term exposure to oil contaminated sediments on the immune response of dab, Limanda limanda (L), Aquat Toxicol, 27, 71, 10.1016/0166-445X(93)90048-6

Secombes, 1997, Immunocompetence in flatfish as a measure of the biological effects of exposure to sewage sludge or hydrocarbon contaminated sediments, 281

Secombes, 1991, Immunocompetence as a measure of the biological effects of sewage sludge pollution in fish, Comp Biochem Physiol, 100C, 133

Karrow, 1999, Characterizing the immunotoxicity of creosote to rainbow trout (Oncorhynchus mykiss): a microcosm study, Aquat Toxicol, 43, 179

Gaby, 1999, Acute-phase proteins and other systemic responses to inflammation, N Engl J Med, 340, 448, 10.1056/NEJM199902113400607

Mortensen, 2000, Regulation of phagocytic leukocyte activities by C-reactive protein, J Leukoc Biol, 67, 495, 10.1002/jlb.67.4.495

Winkelhake, 1983, Induction in rainbow trout of an acute phase (C-reactive) protein by chemicals of environmental concern, Comp Biochem Physiol C, 74, 55, 10.1016/0742-8413(83)90148-2

Ghosh, 1992, Elevation of C-reactive protein in serum of Chana punctatus as an indicator of water pollution, Indian J Exp Biol, 30, 736

Paul, 1998, Effect of environmental pollutants on the C-reactive protein of a freshwater major carp, Catla catla, Dev Comp Immunol, 22, 519, 10.1016/S0145-305X(98)00031-7

Babich, 1991, Cytotoxicity and genotoxicity assays with cultured fish cells: a review, Toxicol Vitr, 5, 91, 10.1016/0887-2333(91)90052-F

Schirmer, 2000, Transitory metabolic disruption and cytotoxicity elicited by benzo[a]pyrene in two cell lines from rainbow trout liver, J Biochem Mol Toxicology, 14, 262, 10.1002/1099-0461(2000)14:5<262::AID-JBT5>3.0.CO;2-2

Janz, 1992, Relative concentrations of cytochrome P450-active organochlorine compounds in liver and muscle of rainbow trout from Lake Ontario, J Great Lakes Res, 18, 759, 10.1016/S0380-1330(92)71335-5

Leong, 1998, Interferon-inducible Mx proteins in fish, Immunol Rev, 166, 349, 10.1111/j.1600-065X.1998.tb01275.x

Hetrick, 1979, Increased susceptibility of rainbow trout to infectious hematopoietic necrosis virus after exposure to copper, Appl Environ Microbiol, 37, 198, 10.1128/AEM.37.2.198-201.1979

Spitsbergen, 1988, Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or Aroclor 1254 on the resistance of rainbow trout, Salmo gairdneri Richardson, to infectious haematopoietic necrosis virus, J Fish Dis, 11, 73, 10.1111/j.1365-2761.1988.tb00524.x

Carls, 1998, Expression of viral hemorrhagic septicemial virus in prespawning Pacific herring (Clupea pallasi) exposed to weathered crude oil, Can J Fish Aquat Sci, 55, 2300, 10.1139/f98-116

Shea, 1983, Enhancement of goldfish virus-2 in vitro replication by the pesticides carbaryl and toxaphane, Appl Environ Microbiol, 45, 1859, 10.1128/AEM.45.6.1859-1864.1983

Shea, 1984, Suppression of interferon synthesis by the pesticide carbaryl as a mechanism for enhancement of goldfish virus-2 replication, Appl Environ Microbiol, 47, 250, 10.1128/AEM.47.2.250-252.1984

Cossarini-Dunier, 1988, Effect of pesticides (atrazine and lindane) on the replication of spring viremia of carp virus in vitro, Ann Rech Vet, 19, 209

Secombes, 1996, The nonspecific immune system: cellular defenses, 63

Dalmo, 1997, Non-specific defence mechanisms in fish, with particular reference to the reticuloendothelial system (RES), J Fish Dis, 20, 241, 10.1046/j.1365-2761.1997.00302.x

Evans, 1992, Nonspecific cytotoxic cells as effectors of immunity in fish, Ann Rev Fish Dis, 2, 109, 10.1016/0959-8030(92)90059-7

Robohom, 1986, Paradoxical effects of cadmium exposure on antibacterial antibody responses in two fish species: inhibition in cunners (Tautogolabrus adspersus) and enhancement in striped bass (Morone saxatilis), Vet Immunol Immunopathol, 12, 251, 10.1016/0165-2427(86)90129-7

Bowser, 1994, Effects of in vitro nickel exposure on the macrophage-mediated immune functions of rainbow trout (Oncorhynchus mykiss), Bull Environ Contam Toxicol, 52, 367, 10.1007/BF00197823

Aaltonen, 2000, Modulation of immune parameters of roach, Rutilus rutilus, exposed to untreated ECF and TCF bleached mill effluents, Aquatic Toxicol, 47, 277, 10.1016/S0166-445X(99)00014-4

Lemaire-Gony, 1995, Effects of cadmium and benzo[a]pyrene on the immune system, gill ATPase and EROD activity of European sea bass Dicentrarchus labrax, Aquat Toxicol, 31, 297, 10.1016/0166-445X(94)00073-Y

Khangarot, 1999, Effects of chromium on humoral and cell-mediated immune responses and host resistance to disease in a freshwater catfish, Saccobranchus fossilis (Bloch), Ecotoxicol Env Saf, 43, 11, 10.1006/eesa.1998.1722

Rougier, 1994, Non-specific immune response of Zebrafish, Brachydanio rerio (Hamilton-Buchanan) following copper and zinc exposure, Fish & Shellfish Immunol, 4, 115, 10.1006/fsim.1994.1010

Dethloff, 1998, Effects of copper on immune system parameters of rainbow trout (Oncorhynchus mykiss), Environ Toxicol Chem, 17, 1807, 10.1002/etc.5620170921

Voccia, 1994, In vitro mercury-related cytotoxicity and functional impairment of the immune cells of rainbow trout (Oncorhynchus mykiss), Aquat Toxicol, 29, 37, 10.1016/0166-445X(94)90046-9

Walczak, 1987, Phagocytic function of monocytes and haematological changes in rainbow trout injected intraperitoneally with benzo(a)-pyrene (BaP) and benzo(a)anthracene (BaA), J Fish Biol, 31A, 251, 10.1111/j.1095-8649.1987.tb05327.x

Holladay, 1998, Benzo[a]pyrene-induced hypocellularity of the pronephros in tilapia (Oreochromis niloticus) is accompanied by alterations in stromal and parenchymal cells and by enhanced immune cell apoptosis, Vet Immunol Immunopathol, 64, 69, 10.1016/S0165-2427(98)00116-0

Hart, 1998, Subacute immunotoxic effects of the polycyclic aromatic hydrocarbon 7,12-dimethylbenzanthracene (DMBA) on spleen and pronephros leukocytic cell counts and phagocytic cell activity in tilapia (Oreochromis niloticus), Aquatic Toxicol, 41, 17, 10.1016/S0166-445X(97)00075-1

Seeley, 1997, Suppression of natural cytotoxic cell and macrophage phagocytic function in oyster toadfish exposed to 7,12-dimethylbenz[a]anthracene, Fish & Shellfish Immunol, 7, 115, 10.1006/fsim.1996.0068

Seeley, 1991, Altered phagocytic activity of macrophages in oyster toadfish from a highly polluted subestuary, J Aquatic Animal Hlth, 3, 224, 10.1577/1548-8667(1991)003<0224:APAOMI>2.3.CO;2

Weeks, 1984, Effects of toxic chemicals on macrophage phagocytosis of two estuarine fishes, Mar Environ Res, 14, 327, 10.1016/0141-1136(84)90086-2

Fournier, 1998, Phagocytic and metabolic activities of macrophages from mummichog naturally exposed to pulp mill effluents in the Miramichi river, Ecotoxicol Env Saf, 40, 177, 10.1006/eesa.1997.1629

Roszell, 1994, Inhibition of phagocytosis and superoxide production by pentachlorophenol in two leukocyte subpopulations from Fundulus heteroclitus, Mar Env Res, 38, 195, 10.1016/0141-1136(94)90007-8

Spitsbergen, 1986, Interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with immune responses of rainbow trout, Vet Immunol Immunopathol, 12, 263, 10.1016/0165-2427(86)90130-3

Babior, 1999, NADPH oxidase: an update, Blood, 93, 1464, 10.1182/blood.V93.5.1464

Clark, 1999, Activation of the neutrophil respiratory burst oxidase, J Infect Dis, 179, S309, 10.1086/513849

Secombes, 1992, NADPH oxidase-like activity in rainbow trout Oncorhynchus mykiss (Walbaum) macrophages, Dev Comp Immunol, 16, 405, 10.1016/0145-305X(92)90042-B

Shiibashi, 1999, Analysis of localization and function of the COOH-terminal corresponding site of cytochrome b558 in fish neutrophils, Dev Comp Immunol, 23, 213, 10.1016/S0145-305X(99)00024-5

Rice, 1996, Innate immune functions as a bioindicator of pollution stress in fish, Ecotoxicol Environ Saf, 33, 186, 10.1006/eesa.1996.0024

Regier, 2000, Phosphorylation of p22phox is mediated by phospholipase D-dependent and -independent mechanisms: correlation of NADPH oxidase activity and p22phox phosphorylation, J Biol Chem, 275, 28406, 10.1074/jbc.M004703200

Rice, 1989, Influence of tributyltin on in vitro activation of oyster toadfish macrophages, J Aquat Animal Health, 1, 62, 10.1577/1548-8667(1989)001<0062:IOTOIV>2.3.CO;2

Rice, 1991, Tributyltin stimulates reactive oxygen formation in toadfish macrophages, Dev Comp Immunol, 15, 431, 10.1016/0145-305X(91)90035-W

Rice, 1995, Immunotoxicity in channel catfish, Ictalurus punctatus, following acute exposure to tributyltin, Arch Environ Contam Toxicol, 28, 464, 10.1007/BF00211629

Rice, 1990, The influence of in vivo exposure to tributyltin on reactive oxygen formation in oyster toadfish macrophages, Arch Environ Contam Toxicol, 19, 854, 10.1007/BF01055050

Wishkovsky, 1989, Effect of tributyltin on the chemiluminescent response of phagocytes from three species of estuarine fish, Arch Environ Contam Toxicol, 18, 826, 10.1007/BF01160296

Chow, 1992, Tributyltin increases cytosolic free Ca2+ concentration in thymocytes by mobilizing intracellular Ca2+, activating a Ca2+ entry pathway, and inhibiting Ca2+ efflux, Arch Biochm Biophys, 298, 143, 10.1016/0003-9861(92)90105-6

Reader, 1999, Tributyltin triggers apoptosis in trout hepatocytes: the role of Ca2+, protein kinase C and proteases, Biochem Biophys Acta, 1448, 473, 10.1016/S0167-4889(98)00166-9

Kim-Park, 1997, Activation of the neutrophil respiratory burst requires both intracellular and extracellular calcium, Ann NY Acad Sci, 832, 394, 10.1111/j.1749-6632.1997.tb46267.x

Larsen, 2000, Differential requirement for classic and novel PKC isoforms in respiratory burst and phagocytosis in RAW 264.7 cells, J Immunol, 165, 2809, 10.4049/jimmunol.165.5.2809

Aldridge, 1977, Action on mitochondria and toxicity of tri-n-butyltin derivatives, Biochem Pharmacol, 26, 1977, 10.1016/0006-2952(77)90008-9

Cima, 1998, Cytoskeletal alterations by tributyltin (TBT) in tunicate phagocytes, Ecotoxicol Environ Saf, 40, 160, 10.1006/eesa.1998.1657

Elsasser, 1986, Effects of metals on the chemiluminescent response of rainbow trout (Salmo gairdneri) phagocytes, Vet Immunol Immunopathol, 12, 243, 10.1016/0165-2427(86)90128-5

Muhvich, 1995, Effects of chronic copper exposure on the macrophage chemiluminescent response and gill histology in goldfish (Carassius auratus L.), Fish Shellfish Immunol, 5, 251, 10.1006/fsim.1995.0025

Naito, 1996, Development, differentiation and phenotypic heterogeneity of murine tissue macrophages, J Leukoc Biol, 59, 133, 10.1002/jlb.59.2.133

Naito, 1993, Macrophage heterogeneity in development and differentiation, Arch Histol Cytol, 56, 331, 10.1679/aohc.56.331

Cossarini-Dunier, 1988, Effects of manganese ions on the immune response of carp, (Cyprinus carpio) against Yersinia ruckeri, Dev Comp Immunol, 12, 573, 10.1016/0145-305X(88)90073-0

Turrens, 1980, Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria, Biochem J, 191, 421, 10.1042/bj1910421

Cossarini-Dunier, 1987, Effects of the pesticides atrazine and lindane and of manganese ions on cellular immunity of carp, Cyprinus carpio, J Fish Biol, 31, 67, 10.1111/j.1095-8649.1987.tb05295.x

Dunier, 1994, Effect of lindane exposure on rainbow trout (Oncorhynchus mykiss) immunity. III. Effect on nonspecific immunity and B lymphocyte functions, Ecotoxicol Environ Saf, 27, 324, 10.1006/eesa.1994.1026

Baier-Anderson, 1998, Evaluation of the immunotoxicity of chlorothalonil to striped bass phagocytes following in vitro exposure, Environ Toxicol Chem, 17, 1546, 10.1002/etc.5620170815

Warinner, 1988, Preliminary investigations of the chemiluminescent response in normal and pollutant-exposed fish, Marine Env Res, 24, 281, 10.1016/0141-1136(88)90321-2

Kelly-Reay, 1994, Determination of the macrophage chemiluminescent response in Fundulus heteroclitus as a function of pollution stress, Fish Shellfish Immunol, 4, 95, 10.1006/fsim.1994.1008

Clemons, 1999, Enhanced superoxide anion production in activated peritoneal macrophages from English sole (Pleuronectes vetulus) exposed to polycyclic aromatic hydrocarbons, Mar Environ Res, 47, 71, 10.1016/S0141-1136(97)00127-X

Rice, 1995, Immune function and cytochrome P4501A activity after acute exposure to 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126) in channnel catfish, J Aquat Animal Health, 7, 195, 10.1577/1548-8667(1995)007<0195:IFACPA>2.3.CO;2

Secombes, 1992, Effects of sewage sludge on immune responses in the dab, Limanda limanda, Aquat Toxicol, 23, 217, 10.1016/0166-445X(92)90054-Q

Anderson, 1993, Inhibition by pentachlorophenol of production of reactive-oxygen intermediates by medaka phagocytic blood cells, Mar Env Res, 35, 125, 10.1016/0141-1136(93)90025-U

Roszell, 1996, Effect of in vivo pentachlorophenol exposure on Fundulus heteroclitus phagocytes: modulations of bactericidal activity, Dis Aquat Org, 26, 205, 10.3354/dao026205

Roszell, 1997, Hydrogen peroxide production and bactericidal activity in pronephros phagocyte sub-populations from Fundulus heteroclitus following exposure to pentachlorophenol, Mar Env Res, 43, 1, 10.1016/0141-1136(95)00024-0

Wolke, 1992, Piscine macrophage aggregates: a review, Ann Rev Fish Dis, 2, 91, 10.1016/0959-8030(92)90058-6

van der Weiden, 1994, Concurrence of P450 1A induction and toxic effects in the mirror carp (Cyprinus carpio), after administration of a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin, Aquat Toxicol, 29, 147, 10.1016/0166-445X(94)90065-5

Kranz, 1987, Effects of sublethal concentrations of potassium dichromate on the occurrence of splenic melano-macrophage centres in juvenile plaice, Pleuronectes platessa, L, J Fish Biol, 31A, 75, 10.1111/j.1095-8649.1987.tb05296.x

Barker, 1994, Anomalies in sculpins (Myoxephalus spp.) sampled near a pulp and paper mill, Arch Environ Contam Toxicol, 26, 491, 10.1007/BF00214152

Couillard, 1996, Pigmented macrophage aggregates: a toxic response in fish exposed to bleached kraft mill effluent?, Environ Toxicol Chem, 15, 1844, 10.1002/etc.5620151027

Hartley, 1996, Liver lesions in the gar fish (Lepisosteidae) as biomarkers of exposure, Mar Environ Res, 42, 217, 10.1016/0141-1136(95)00037-2

Payne, 1989, Effect of polycyclic aromatic hydrocarbons on immune responses in fish: Changes in melano-macrophage centers in flounder (Pseudopleuronectes americanus) exposed to hydrocarbon-contaminated sediments, Mar Environ Res, 28, 431, 10.1016/0141-1136(89)90274-2

Weeks, 1986, Influence of toxic chemicals on the chemotactic response of fish macrophages, J Fish Biol, 28, 653, 10.1111/j.1095-8649.1986.tb05200.x

Blazer, 1987, Piscine macrophage aggregate parameters as health monitors: effect of age, sex, relative weight, season and site quality in largemouth bass (Micropterus salmoides), Aquatic Toxicol, 10, 199, 10.1016/0166-445X(87)90012-9

Haaparanta, 1996, Do macrophage centres in freshwater fishes reflect the differences in water quality?, Aquatic Toxicol, 34, 253, 10.1016/0166-445X(95)00042-3

Smolowitz, 1991, Immunocytochemical localization of cytchrome P-4501A1 induced by 3,3′,4,4′-tetrachlorobiphenyl and by 2,3,7,8-tetrachlorodibenzoafuran in liver and extrahepatic tissues of the teleost Stenotomus chrysops (scup), Drug Metab Dispos, 19, 113

Stegeman, 1991, Immunohistochemical localization of environmentally induced cytochrome P4501A1 in multiple organs of the marine teleost Stentotomus chrysops (scup), Toxicol Appl Pharmacol, 110, 486, 10.1016/0041-008X(91)90049-K

Van Veld, 1997, Route-specific cellular expression of cytochrome P4501A (CYP1A) in fish (Fundulus heteroclitus) following exposure to aqueous and dietary benzo[a] pyrene, Toxicol Appl Pharmacol, 142, 348, 10.1006/taap.1996.8037

Ristow, 2000, Analyzing nonspecific cytotoxic cells in fish, Methods Mol Biol, 121, 347

Cleland, 1987, Natural killer cell activity in rainbow trout (Salmo gairdneri): effect of dietary exposure to aroclor 1254 and/or mirex, Can J Fish Aquat Sci, 44, 636, 10.1139/f87-077

O'Halloran, 1996, In vitro responses of fish immune cells to three classes of pesticides, 535

Ghanmi, 1990, Modulatory effect of metal ions on the immune response of fish: in vivo and in vitro influence of MnCl2 on NK activity of carp pronephros cells, Ecotoxicol Env Saf, 20, 241, 10.1016/0147-6513(90)90003-N

Taysse, 1995, Structure–activity relationship of phenolic compounds (phenol, pyrocatechol and hydroquinone) on natural lymphocytotoxicity of carp (Cyprinus carpio), Toxicology, 98, 207, 10.1016/0300-483X(94)03011-P

Faisal, 1991, Evidence of aberration of the natural cytotoxic cell activity in Fundulus heteroclitus (Pisces: Cyprinodontidae) from Elizabeth River, Virginia, Vet Immunol Immunopathol, 29, 339, 10.1016/0165-2427(91)90024-7

Ellis, 1986, The function of teleost fish lymphocytes in relation to inflammation, Int J Tissue React, 8, 263

Munkittrick, 1992, Changes in maturity, plasma sex steroid levels, hepatic mixed-function oxygenase activity, and the presence of external lesions in Lake Whitefish (Coregonus clupeaformis) exposed to bleached kraft mill effluent, Can J Fish Aquat Sci, 49, 1560, 10.1139/f92-173

Babior, 1973, The production by leukocytes of superoxide, a potent bactericidal agent, J Clin Invest, 52, 741, 10.1172/JCI107236

Auclair, 1985, Nitroblue tetrazolium reduction, 123

Allen, 1972, Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity, Biochem Biophys Res Commun, 47, 679, 10.1016/0006-291X(72)90545-1

Allen, 1986, Phagocytic leukocyte oxygenation activities and chemiluminescence: a kinetic approach to analysis, Methods Enzymol, 133, 449, 10.1016/0076-6879(86)33085-4

Pick, 1980, Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages—induction by multiple nonphagocytic stimuli, Cell Immunol, 59, 301, 10.1016/0008-8749(81)90411-1

Bass, 1983, Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation, J Immunol, 130, 1910, 10.4049/jimmunol.130.4.1910

LeBel, 1992, Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress, Chem Res Toxicol, 5, 227, 10.1021/tx00026a012

Royall, 1993, Evaluation of 2′,7′-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells, Arch Biochem Biophys, 302, 348, 10.1006/abbi.1993.1222