Economic modeling of risk-adapted screen-and-treat strategies in women at high risk for breast or ovarian cancer

citation_journal_title=Lancet Oncol.; citation_title=Economic burden of cancer across the European Union: a population-based cost analysis; citation_author=R Luengo-Fernandez, J Leal, A Gray, R Sullivan; citation_volume=14; citation_issue=12; citation_publication_date=2013; citation_pages=1165-1174; citation_doi=10.1016/S1470-2045(13)70442-X; citation_id=CR1 citation_journal_title=JAMA; citation_title=Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers; citation_author=KB Kuchenbaecker, JL Hopper, DR Barnes, KA Phillips, TM Mooij, MJ Roos-Blom, S Jervis, FE Leeuwen, RL Milne, N Andrieu, DE Goldgar, MB Terry, MA Rookus, DF Easton, AC Antoniou, L McGuffog, DG Evans, D Barrowdale, D Frost, J Adlard, KR Ong, L Izatt, M Tischkowitz, R Eeles, R Davidson, S Hodgson, S Ellis, C Nogues, C Lasset, D Stoppa-Lyonnet, JP Fricker, L Faivre, P Berthet, MJ Hooning, LE Kolk, CM Kets, MA Adank, EM John, WK Chung, IL Andrulis, M Southey, MB Daly, SS Buys, A Osorio, C Engel, K Kast, RK Schmutzler, T Caldes, A Jakubowska, J Simard, ML Friedlander, SA McLachlan, E Machackova, L Foretova, YY Tan, CF Singer, E Olah, AM Gerdes, B Arver, H Olsson; citation_volume=317; citation_issue=23; citation_publication_date=2017; citation_pages=2402-2416; citation_doi=10.1001/jama.2017.7112; citation_id=CR2 citation_journal_title=Dtsch. Arztebl. Int; citation_title=Hereditary breast and ovarian cancer: new genes, new treatments, new concepts; citation_author=A Meindl, N Ditsch, K Kast, K Rhiem, RK Schmutzler; citation_volume=108; citation_issue=19; citation_publication_date=2011; citation_pages=323-330; citation_doi=10.3238/arztebl.2011.0323; citation_id=CR3 citation_journal_title=Arch. Gynecol. Obstet.; citation_title=Changes in classification of genetic variants in BRCA1 and BRCA2; citation_author=K Kast, P Wimberger, N Arnold; citation_volume=297; citation_issue=2; citation_publication_date=2018; citation_pages=279-280; citation_doi=10.1007/s00404-017-4631-2; citation_id=CR4 Leitlinienprogramm Onkologie der AWMF, Deutschen Krebsgesellschaft e.V. und Deutschen Krebshilfe e.V. Interdisziplinäre S3-Leitlinie für die Diagnostik, Therapie und Nachsorge des Mammakarzinoms (2017). https://www.awmf.org/leitlinien/detail/ll/032-045OL.html . Accessed 15 Jan 2019 citation_journal_title=Eur. J. Health Econ.; citation_title=Cost-effectiveness of different strategies to prevent breast and ovarian cancer in German women with a BRCA 1 or 2 mutation; citation_author=D Müller, M Danner, K Rhiem, B Stollenwerk, C Engel, L Rasche, L Borsi, R Schmutzler, S Stock; citation_volume=19; citation_issue=3; citation_publication_date=2017; citation_pages=341-353; citation_doi=10.1007/s10198-017-0887-5; citation_id=CR6 Institute for Quality and Efficiency in Health Care. General Methods 5.0. Cologne, Germany (2017) citation_journal_title=J. Med. Genet.; citation_title=German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC). Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer; citation_author=K Kast, K Rhiem, B Wappenschmidt, E Hahnen, J Hauke, B Bluemcke, V Zarghooni, N Herold, N Ditsch, M Kiechle, M Braun, C Fischer, N Dikow, S Schott, N Rahner, D Niederacher, T Fehm, A Gehrig, C Mueller-Reible, N Arnold, N Maass, G Borck, N Gregorio, C Scholz, B Auber, R Varon-Manteeva, D Speiser, J Horvath, N Lichey, P Wimberger, S Stark, U Faust, BH Weber, G Emons, S Zachariae, A Meindl, RK Schmutzler, C Engel; citation_volume=53; citation_issue=7; citation_publication_date=2016; citation_pages=465-471; citation_doi=10.1136/jmedgenet-2015-103672; citation_id=CR8 citation_journal_title=J. Mol. Diagn.; citation_title=Next-generation sequencing of the BRCA1 and BRCA2 genes for the genetic diagnostics of hereditary breast and/or ovarian cancer; citation_author=D Trujillano, ME Weiss, J Schneider, J Köster, EB Papachristos, V Saviouk, T Zakharkina, N Nahavandi, L Kovacevic, A Rolfs; citation_volume=17; citation_issue=2; citation_publication_date=2015; citation_pages=162-170; citation_doi=10.1016/j.jmoldx.2014.11.004; citation_id=CR9 Wassermann, K., Rhiem, K., Schmutzler, R.K.: Impact of anxiety and personality factors on the intention for preventive measures in BRCA1/2 mutation carriers: Results of a prospective cohort study. Submitted to Cancer Medicine (under review; manuscript ID: CAM4-2018-06-1548) (2018) citation_journal_title=Dtsch. Arztebl.; citation_title=Early breast cancer detection in Germany—knowledge and acceptance among the female population; citation_author=S Paepke, U Schwarz-Boeger, G Minckwitz, B Schultz-Zehden, M Kaufmann, H Beck; citation_volume=98; citation_issue=34–35; citation_publication_date=2001; citation_pages=A-2178/B-1849/C-1741; citation_id=CR11 Engel, C., Fischer, C., Zachariae, S., Bucksch, K., Rhiem, K., Giesecke, J., Herold, N., Wappenschmidt, B., Hübbel, V., Maringa, M., Reichstein-Gnielinski, S., Hahnen, E., Bartram, C.R., Dikow, N., Schott, S., Speiser, D., Horn, D., Fallenberg, E.M., Kiechle, M., Quante, A.S., Vesper, A.S., Fehm, T., Mundhenke, C., Arnold, N., Leinert, E., Just, W., Siebers-Renelt, U., Weigel, S., Gehrig, A., Wöckel, A., Schlegelberger, B., Pertschy, S., Kast, K., Wimberger, P., Briest, S., Loeffler, M., Bick, U.,. Schmutzler, R.K.: Breast cancer risk in BRCA1/2 mutation carriers and high-risk non-carriers: 3 a prospective cohort study. Int. J. Cancer (submitted, Ref.: IJC-18-3386) citation_journal_title=Eur. J. Cancer Prev.; citation_title=GEKID Cancer Survival Working Group. Survival of ovarian cancer patients in Germany in the early 21st century: a period analysis by age, histology, laterality, and stage; citation_author=T Chen, L Jansen, A Gondos, K Emrich, B Holleczek, A Katalinic, S Luttmann, M Meyer, H Brenner; citation_volume=22; citation_issue=1; citation_publication_date=2013; citation_pages=59-67; citation_doi=10.1097/CEJ.0b013e3283552e28; citation_id=CR13 citation_title=Cancer Incidence for Common Cancers. The 10 Most Common Cancers in Females; citation_publication_date=2012; citation_id=CR14; citation_publisher=Cancer Research United Kingdom Federal Statistical Office of Germany. Life expectancy 2015 (2017). https://www.destatis.de/EN/FactsFigures/SocietyState/Population/Deaths/Deaths.html . Accessed 15 Jan 2019 citation_journal_title=Breast Cancer Res. Treat.; citation_title=Impact of comorbidity on mortality: a cohort study of 62,591 Danish women diagnosed with early breast cancer, 1990–2008; citation_author=LH Land, SO Dalton, MB Jensen, M Ewertz; citation_volume=131; citation_issue=3; citation_publication_date=2012; citation_pages=1013-1020; citation_doi=10.1007/s10549-011-1819-1; citation_id=CR16 citation_journal_title=Lancet Oncol.; citation_title=Breast conserving therapy versus mastectomy for stage I-II breast cancer: 20 year follow-up of the EORTC 10801 phase 3 randomised trial; citation_author=S Litière, G Werutsky, IS Fentiman, E Rutgers, MR Christiaens, E Limbergen, MH Baaijens, J Bogaerts, H Bartelink; citation_volume=13; citation_issue=4; citation_publication_date=2012; citation_pages=412-419; citation_doi=10.1016/S1470-2045(12)70042-6; citation_id=CR17 citation_journal_title=JAMA; citation_title=Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality; citation_author=SM Domchek, TM Friebel, CF Singer, DG Evans, HT Lynch, C Isaacs, JE Garber, SL Neuhausen, E Matloff, R Eeles, G Pichert, L t’veer, N Tung, JN Weitzel, FJ Couch, WS Rubinstein, PA Ganz, MB Daly, OI Olopade, G Tomlinson, J Schildkraut, JL Blum, TR Rebbeck; citation_volume=304; citation_issue=9; citation_publication_date=2010; citation_pages=967-975; citation_doi=10.1001/jama.2010.1237; citation_id=CR18 citation_journal_title=BMC Cancer; citation_title=Trends of population-based breast cancer survival in Germany and the US: decreasing discrepancies, but persistent survival gap of elderly patients in Germany; citation_author=B Holleczek, H Brenner; citation_volume=28; citation_issue=12; citation_publication_date=2012; citation_pages=317; citation_doi=10.1186/1471-2407-12-317; citation_id=CR19 citation_journal_title=J. Clin. Oncol.; citation_title=Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group; citation_author=TR Rebbeck, T Friebel, HT Lynch, SL Neuhausen, L ‘t Veer, JE Garber, GR Evans, SA Narod, C Isaacs, E Matloff, MB Daly, OI Olopade, BL Weber; citation_volume=22; citation_issue=6; citation_publication_date=2004; citation_pages=1055-1062; citation_doi=10.1200/JCO.2004.04.188; citation_id=CR20 citation_journal_title=Ann. Surg. Oncol; citation_title=Contralateral prophylactic mastectomy is associated with a survival advantage in high-risk women with a personal history of breast cancer; citation_author=JC Boughey, TL Hoskin, AC Degnim, TA Sellers, JL Johnson, MJ Kasner, LC Hartmann, MH Frost; citation_volume=17; citation_issue=10; citation_publication_date=2010; citation_pages=2702-2709; citation_doi=10.1245/s10434-010-1136-7; citation_id=CR21 citation_journal_title=J. Natl. Cancer Inst.; citation_title=EMBRACE.:Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE; citation_author=N Mavaddat, S Peock, D Frost, S Ellis, R Platte, E Fineberg, DG Evans, L Izatt, RA Eeles, J Adlard, R Davidson, D Eccles, T Cole, J Cook, C Brewer, M Tischkowitz, F Douglas, S Hodgson, L Walker, ME Porteous, PJ Morrison, LE Side, MJ Kennedy, C Houghton, A Donaldson, MT Rogers, H Dorkins, Z Miedzybrodzka, H Gregory, J Eason, J Barwell, E McCann, A Murray, AC Antoniou, DF Easton; citation_volume=105; citation_issue=11; citation_publication_date=2013; citation_pages=812-822; citation_doi=10.1093/jnci/djt095; citation_id=CR22 citation_journal_title=Med. Care; citation_title=A national catalog of preference-based scores for chronic conditions in the United States; citation_author=PW Sullivan, WF Lawrence, V Ghushchyan; citation_volume=43; citation_publication_date=2005; citation_pages=736-749; citation_doi=10.1097/01.mlr.0000172050.67085.4f; citation_id=CR23 citation_journal_title=Breast Cancer Res. Treat.; citation_title=Breast cancer-related preferences among women with and without BRCA mutations; citation_author=VR Grann, P Patel, A Bharthuar, JS Jacobson, E Warner, K Anderson, E Warner, WY Tsai, KA Hill, AI Neugut, D Hershman; citation_volume=119; citation_issue=1; citation_publication_date=2010; citation_pages=177-184; citation_doi=10.1007/s10549-009-0373-6; citation_id=CR24 citation_journal_title=Cancer J. Sci. Am.; citation_title=The quality of life associated with prophylactic treatments for women with BRCA1/2 mutations; citation_author=VR Grann, JS Jacobson, V Sundararajan, SM Albert, AB Troxel, AI Neugut; citation_volume=5; citation_issue=5; citation_publication_date=1999; citation_pages=283-292; citation_id=CR25 citation_journal_title=Expert Rev. Pharmacoecon. Outcomes Res.; citation_title=Health-state utility values in breast cancer; citation_author=T Peasgood, SE Ward, J Brazier; citation_volume=10; citation_issue=5; citation_publication_date=2010; citation_pages=553-566; citation_doi=10.1586/erp.10.65; citation_id=CR26 citation_journal_title=Gynecol. Oncol.; citation_title=Determination of quality of life-related utilities for health states relevant to ovarian cancer diagnosis and treatment; citation_author=LJ Havrilesky, G Broadwater, DM Davis, KC Nolte, JC Barnett, ER Myers, S Kulasingam; citation_volume=113; citation_issue=2; citation_publication_date=2009; citation_pages=216-220; citation_doi=10.1016/j.ygyno.2008.12.026; citation_id=CR27 citation_journal_title=Value Health; citation_title=Using health state utility values in models exploring the cost-effectiveness of health technologies; citation_author=R Ara, A Wailoo; citation_volume=15; citation_issue=6; citation_publication_date=2012; citation_pages=971-974; citation_doi=10.1016/j.jval.2012.05.003; citation_id=CR28 German Consortium for Hereditary Breast and Ovarian Cancer (2017). http://www.krebshilfe.de/wir-helfen/adressen/familiaerer-krebs/brustkrebszentren.html . Accessed 15 Jan 2019 Heemskerk-Gerritsen, B.A., Seynaeve, C., van Asperen, C.J., Ausems, M.G., Collée, J.M., van Doorn, H.C., Gomez Garcia, E.B., Kets, C.M., van Leeuwen, F.E., Meijers-Heijboer, H.E., Mourits, M.J., van Os, T.A., Vasen, H.F., Verhoef, S., Rookus, M.A., Hooning, M.J., Hereditary Breast and Ovarian Cancer Research Group Netherlands: Breast cancer risk after salpingo-oophorectomy in healthy BRCA1/2 mutation carriers: revisiting the evidence for risk reduction. J Natl Cancer Inst 107(5) (2015) DRG-Webgrouper. http://drg.uni-muenster.de . Accessed 15 Jan 2019 citation_journal_title=Biomed. Res. Int.; citation_title=Guideline concordant therapy prolongs survival in HER2-positive breast cancer patients: results from a large population-based cohort of a cancer registry; citation_author=EC Inwald, O Ortmann, F Zeman, M Koller, F Hofstädter, M Gerstenhauer, M Klinkhammer-Schalke; citation_volume=2014; citation_publication_date=2014; citation_pages=137304; citation_doi=10.1155/2014/137304; citation_id=CR32 citation_journal_title=J. Comp. Eff. Res.; citation_title=Treatment pattern by hormone receptors and HER2 status in patients with metastatic breast cancer in the UK, Germany, France, Spain and Italy (EU-5): results from a physician survey; citation_author=M DeKoven, V Bonthapally, X Jiao, A Ganguli, P Pathak, WC Lee, S Ray; citation_volume=1; citation_issue=5; citation_publication_date=2012; citation_pages=453-463; citation_doi=10.2217/cer.12.43; citation_id=CR33 citation_journal_title=Drugs; citation_title=Triple-negative breast cancer: epidemiology and management options; citation_author=S Dawood; citation_volume=70; citation_issue=17; citation_publication_date=2010; citation_pages=2247-2258; citation_doi=10.2165/11538150-000000000-00000; citation_id=CR34 citation_journal_title=Breast Cancer Res. Treat.; citation_title=Effect of HER2 status on distant recurrence in early stage breast cancer; citation_author=KR Hess, FJ Esteva; citation_volume=137; citation_issue=2; citation_publication_date=2013; citation_pages=449-455; citation_doi=10.1007/s10549-012-2366-0; citation_id=CR35 Lauer-Taxe. https://www.cgm.com/lauer-fischer/loesungen_lf/lauer_taxe_lf/lauer_taxe_download_lf/lauer_taxe_download.de.jsp . Accessed 15 Jan 2019 citation_journal_title=Breast; citation_title=Cost-effectiveness of risk-reducing surgeries in preventing hereditary breast and ovarian cancer; citation_author=MG Schrauder, L Brunel-Geuder, L Häberle, M Wunderle, J Hoyer, A Reis, R Schulz-Wendtland, MW Beckmann, MP Lux; citation_volume=32; citation_publication_date=2017; citation_pages=186-191; citation_doi=10.1016/j.breast.2017.02.008; citation_id=CR37 citation_journal_title=Breast Care; citation_title=Cost benefit analysis of endocrine therapy in the adjuvant setting for postmenopausal patients with hormone receptor-positive breast cancer, based on survival data and future prices for generic drugs in the context of the german health care system; citation_author=MP Lux, C Reichelt, J Karnon, TD Tanzer, D Radosavac, PA Fasching, MW Beckmann, FC Thiel; citation_volume=6; citation_publication_date=2011; citation_pages=381e9; citation_doi=10.1159/000333118; citation_id=CR38 citation_journal_title=Breast Cancer Res. Treat.; citation_title=Impact of chemotherapy beyond the first line in patients with metastatic breast cancer; citation_author=A Dufresne, X Pivot, C Tournigand, T Facchini, T Altweegg, L Chaigneau, A Gramont; citation_volume=107; citation_issue=2; citation_publication_date=2008; citation_pages=275-279; citation_doi=10.1007/s10549-007-9550-7; citation_id=CR39 Federal Statistical Office Germany (DESTATIS). Medical expenses (Germany) (2015). https://www-genesis.destatis.de/genesis/online/link/tabelleErgebnis/23631-0002 . Accessed 15 Jan 2019 citation_journal_title=Genet Med; citation_title=Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology; citation_author=S Richards, N Aziz, S Bale, D Bick, S Das, J Gastler-Foster; citation_volume=17; citation_issue=5; citation_publication_date=2015; citation_pages=405-424; citation_doi=10.1038/gim.2015.30; citation_id=CR41 citation_journal_title=Breast Cancer Res.; citation_title=The risk of contralateral breast cancer in patients from BRCA1/2 negative high risk families as compared to patients from BRCA1 or BRCA2 positive families: a retrospective cohort study; citation_author=K Rhiem, C Engel, M Graeser, S Zachariae, K Kast, M Kiechle, N Ditsch, W Janni, C Mundhenke, M Golatta, D Varga, S Preisler-Adams, T Heinrich, U Bick, D Gadzicki, S Briest, A Meindl, RK Schmutzler; citation_volume=14; citation_issue=6; citation_publication_date=2012; citation_pages=R156; citation_doi=10.1186/bcr3369; citation_id=CR42 citation_journal_title=J. Clin. Oncol.; citation_title=Impact of age at primary breast cancer on contralateral breast cancer risk in BRCA1/2 mutation carriers; citation_author=AJ Broek, LJ ‘t Veer, MJ Hooning, S Cornelissen, A Broeks, EJ Rutgers, VT Smit, CJ Cornelisse, M Beek, ML Janssen-Heijnen, C Seynaeve, PJ Westenend, JJ Jobsen, S Siesling, RA Tollenaar, FE Leeuwen, MK Schmidt; citation_volume=34; citation_issue=5; citation_publication_date=2016; citation_pages=409-418; citation_doi=10.1200/JCO.2015.62.3942; citation_id=CR43 citation_journal_title=J. Clin. Oncol.; citation_title=Ten-year multi-institutional results of breast-conserving surgery and radiotherapy in BRCA1/2-associated stage I/II breast cancer; citation_author=LJ Pierce, AM Levin, TR Rebbeck, MA Ben-David, E Friedman, LJ Solin, EE Harris, DK Gaffney, BG Haffty, LA Dawson, SA Narod, IA Olivotto, A Eisen, TJ Whelan, OI Olopade, C Isaacs, SD Merajver, JS Wong, JE Garber, BL Weber; citation_volume=24; citation_issue=16; citation_publication_date=2006; citation_pages=2437-2443; citation_doi=10.1200/JCO.2005.02.7888; citation_id=CR44 citation_journal_title=Cancer; citation_title=Risk of metachronous breast cancer after BRCA mutation-associated ovarian cancer; citation_author=SM Domchek, K Jhaveri, S Patil, JE Stopfer, C Hudis, J Powers, Z Stadler, L Goldstein, N Kauff, M Khasraw, K Offit, KL Nathanson, M Robson; citation_volume=119; citation_issue=7; citation_publication_date=2013; citation_pages=1344-1348; citation_doi=10.1002/cncr.27842; citation_id=CR45 citation_journal_title=Breast Cancer Res. Treat.; citation_title=Use of risk-reducing surgeries in a prospective cohort of 1,499 BRCA1 and BRCA2 mutation carriers; citation_author=X Chai, TM Friebel, CF Singer, DG Evans, HT Lynch, C Isaacs, JE Garber, SL Neuhausen, E Matloff, R Eeles, N Tung, JN Weitzel, FJ Couch, PJ Hulick, PA Ganz, MB Daly, OI Olopade, G Tomlinson, JL Blum, SM Domchek, J Chen, TR Rebbeck; citation_volume=148; citation_issue=2; citation_publication_date=2014; citation_pages=397-406; citation_doi=10.1007/s10549-014-3134-0; citation_id=CR46 citation_journal_title=Qual. Life Res.; citation_title=Measuring women’s preferences for breast cancer treatments and BRCA1/BRCA2 testing; citation_author=M Cappelli, L Surh, L Humphreys, S Verma, D Logan, A Hunter, J Allanson; citation_volume=10; citation_issue=7; citation_publication_date=2001; citation_pages=595-607; citation_doi=10.1023/A:1013123915272; citation_id=CR47 citation_journal_title=J. Clin. Epidemiol.; citation_title=The standard gamble showed better construct validity than the time trade-off; citation_author=MA Puhan, HJ Schünemann, E Wong, L Griffith, GH Guyatt; citation_volume=60; citation_issue=10; citation_publication_date=2007; citation_pages=1029-1033; citation_doi=10.1016/j.jclinepi.2007.03.001; citation_id=CR48 citation_journal_title=Eur. J. Cancer; citation_title=Body image and psychological distress after prophylactic mastectomy and breast reconstruction in genetically predisposed women: a prospective long-term follow-up study; citation_author=M Heijer, C Seynaeve, R Timman, HJ Duivenvoorden, K Vanheusden, M Tilanus-Linthorst, MB Menke-Pluijmers, A Tibben; citation_volume=48; citation_issue=9; citation_publication_date=2012; citation_pages=1263-1268; citation_doi=10.1016/j.ejca.2011.10.020; citation_id=CR49 citation_journal_title=Psychooncology; citation_title=Long-term psychological distress in women at risk for hereditary breast cancer adhering to regular surveillance: a risk profile; citation_author=M Heijer, C Seynaeve, K Vanheusden, R Timman, HJ Duivenvoorden, M Tilanus-Linthorst, MB Menke-Pluijmers, A Tibben; citation_volume=22; citation_issue=3; citation_publication_date=2013; citation_pages=598-604; citation_doi=10.1002/pon.3039; citation_id=CR50 citation_journal_title=Hered. Cancer Clin. Pract.; citation_title=Long-term satisfaction and quality of life following risk reducing surgery in BRCA1/2 mutation carriers; citation_author=GW Hooker, L King, L Vanhusen, K Graves, BN Peshkin, C Isaacs, KL Taylor, E Poggi, MD Schwartz; citation_volume=12; citation_issue=1; citation_publication_date=2014; citation_pages=9; citation_doi=10.1186/1897-4287-12-9; citation_id=CR51 citation_journal_title=Health Econ.; citation_title=Should the consumption of survivors be included as a cost in cost-utility analysis?; citation_author=JA Nyman; citation_volume=13; citation_issue=5; citation_publication_date=2004; citation_pages=417-427; citation_doi=10.1002/hec.850; citation_id=CR52 citation_journal_title=Value Health; citation_title=Cost-effectiveness of testing for breast cancer susceptibility genes; citation_author=ML Holland, A Huston, K Noyes; citation_volume=12; citation_issue=2; citation_publication_date=2009; citation_pages=207-216; citation_doi=10.1111/j.1524-4733.2008.00418.x; citation_id=CR53 National Institute for Health and Care Excellence (NICE). Familial breast cancer: Classification and care of people at risk of familial breast cancer and management of breast cancer and related risks in people with a family history of breast cancer (2015). https://www.nice.org.uk/guidance/cg164/evidence/cg164-familial-breast-cancer-full-guideline . Accessed 15 Jan 2019