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Liệu pháp quang động lực học sớm so với muộn cho bệnh lý chorioretinopathy trung tâm serous mãn tính
Tóm tắt
Bệnh nhân chorioretinopathy trung tâm serous (CSCR) đôi khi được chỉ định liệu pháp quang động lực học (PDT) với bệnh lý kéo dài rất lâu. Mục tiêu của nghiên cứu này là phân tích kết quả của PDT ở những mắt CSCR có bệnh lý lâu dài. Hồ sơ y tế của các bệnh nhân đã trải qua PDT cho CSCR trong giai đoạn từ 2009 đến 2019 đã được xem xét. Các trường hợp được chia thành hai nhóm dựa trên thời gian mắc bệnh trước khi điều trị bằng PDT: điều trị sớm (3 đến 6 tháng) và điều trị muộn (lớn hơn 6 tháng). Việc điều trị được định nghĩa là thành công khi dịch ở dưới võng mạc được hấp thu trong quá trình theo dõi. Điều trị PDT thành công ở 76% và 77% các mắt trong nhóm điều trị sớm và nhóm điều trị muộn, tương ứng. Cả hai nhóm đều cho thấy sự cải thiện đáng kể trong các thước đo võng mạc trung tâm ở lần theo dõi sau 3 tháng, và sự cải thiện này vẫn duy trì đến lần theo dõi cuối cùng. Thị lực (VA) tại thời điểm xuất phát có sự khác biệt rõ rệt hơn trong nhóm điều trị muộn (0.5 ± 0.26 so với 0.3 ± 0.24, P = 0.042) và đã cải thiện ở cả hai nhóm nhưng vẫn duy trì ở mức thấp trong nhóm điều trị muộn trong suốt thời gian nghiên cứu. Chúng tôi đề xuất rằng nếu CSCR không tự cải thiện sau 3 tháng, bệnh nhân nên được đề nghị PDT, nhằm ngăn ngừa mất thị lực từ sự hiện diện lâu dài của dịch dưới võng mạc ở hoàng điểm. PDT không liên quan đến việc mất thị lực ở những mắt bị CSCR mạn tính, và có thể được sử dụng an toàn ở những mắt có thị lực tương đối tốt.
Từ khóa
#chorioretinopathy trung tâm serous #liệu pháp quang động lực học #thị lực #dịch dưới võng mạc #cải thiện thị lựcTài liệu tham khảo
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