Early-onset endothelin receptor blockade in hypertensive heterozygous Ren-2 rats

Allcock, 1998, ETA receptor blockade attenuates the hypertension but not renal dysfunction in DOCA-salt rats, Am. J. Physiol., 275, R245 Barton, 1998, ET(A) receptor blockade prevents increased tissue endothelin-1, vascular hypertrophy, and endothelial dysfunction in salt-sensitive hypertension, Hypertension, 31, 499, 10.1161/01.HYP.31.1.499 Blezer, 1999, Early-onset but not late-onset endothelin-A-receptor blockade can modulate hypertension, cerebral edema, and proteinuria in stroke-prone hypertensive rats, Hypertension, 33, 137, 10.1161/01.HYP.33.1.137 Bohlender, 2000, Synergistic effects of AT(1) and ET(A) receptor blockade in a transgenic, angiotensin II-dependent, rat model, Hypertension, 35, 992, 10.1161/01.HYP.35.4.992 Callahan, 1996, Salt-sensitive hypertension in (mREN-2)27 transgenic rats, Hypertension, 27, 573, 10.1161/01.HYP.27.3.573 Dahl, 1968, Effects of chronic excess salt ingestion. Modification of experimental hypertension in the rat by variations in the diet, Circ. Res., 22, 11, 10.1161/01.RES.22.1.11 D'Angelo, 2005, Endogenous endothelin attenuates the pressor response to acute environmental stress via the ETA receptor, Am. J. Physiol. Heart Circ. Physiol., 288, H1829, 10.1152/ajpheart.00844.2004 de Nucci, 1988, Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled, Proc. Natl. Acad. Sci. U. S. A., 85, 2334, 10.1073/pnas.85.7.2334 Dvorak, 2004, Blockade of endothelin receptors attenuates end-organ damage in homozygous hypertensive ren-2 transgenic rats, Kidney Blood Press Res., 27, 248, 10.1159/000080052 Ehmke, 1999, Chronic ETA receptor blockade attenuates cardiac hypertrophy independently of blood pressure effects in renovascular hypertensive rats, Hypertension, 33, 954, 10.1161/01.HYP.33.4.954 Elmarakby, 2004, ETA receptor blockade attenuates hypertension and decreases reactive oxygen species in ETB receptor-deficient rats, J. Cardiovasc. Pharmacol., 44, S7, 10.1097/01.fjc.0000166205.66555.40 Gardiner, 2000, Cardiovascular effects of endothelin-1 and endothelin antagonists in conscious, hypertensive ((mRen-2)27) rats, Br. J. Pharmacol., 131, 1732, 10.1038/sj.bjp.0703767 Gariepy, 2000, Salt-sensitive hypertension in endothelin-B receptor-deficient rats, J. Clin. Invest., 105, 925, 10.1172/JCI8609 Gellai, 1996, Evidence for the existence of endothelin-B receptor subtypes and their physiological roles in the rat, Am. J. Physiol., 271, R254 Hirata, 1989, Endothelin is a potent mitogen for rat vascular smooth muscle cells, Atherosclerosis, 78, 225, 10.1016/0021-9150(89)90227-X Inscho, 2005, ET(A) and ET(B) receptors differentially modulate afferent and efferent arteriolar responses to endothelin, Br. J. Pharmacol., 146, 1019, 10.1038/sj.bjp.0706412 Just, 2004, Dual constrictor and dilator actions of ET(B) receptors in the rat renal microcirculation: interactions with ET(A) receptors, Am. J. Physiol., Renal Physiol., 286, F660, 10.1152/ajprenal.00368.2003 Kenyon, 2003, Bosentan for the treatment of pulmonary arterial hypertension, Ann. Pharmacother., 37, 1055, 10.1345/aph.1C256 Konishi, 2002, Role of endothelin ET(B) receptors in the renal hemodynamic and excretory responses to big endothelin-1, Eur. J. Pharmacol., 451, 177, 10.1016/S0014-2999(02)02228-8 Masaki, 2004, Historical review: endothelin, Trends Pharmacol. Sci., 25, 219, 10.1016/j.tips.2004.02.008 Moreau, 2003, Role of endothelins in animal models of hypertension: focus on cardiovascular protection, Can. J. Physiol. Pharm., 81, 511, 10.1139/y03-015 Mulder, 2000, Selective endothelin-a versus combined endothelin-A/endothelin-B receptor blockade in rat chronic heart failure, Circulation, 102, 491, 10.1161/01.CIR.102.5.491 Mullins, 1990, Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene, Nature, 344, 541, 10.1038/344541a0 Nelson, 2003, Endothelin inhibition: novel therapy for prostate cancer, J. Urol., 170, S65, 10.1097/01.ju.0000096372.07687.86 Ohkita, 2005, Extrarenal ETB plays a significant role in controlling cardiovascular responses to high dietary sodium in rats, Hypertension, 45, 940, 10.1161/01.HYP.0000161878.81141.62 Opgenorth, 1996, Pharmacological characterization of A-127722: an orally active and highly potent ETA-selective receptor antagonist, J. Pharmacol. Exp. Ther., 276, 473 Opocensky, 2004, Chronic endothelin receptor blockade reduces end-organ damage independently of blood pressure effects in salt-loaded heterozygous Ren-2 transgenic rats, Physiol. Res., 53, 581 Opocensky, M., Kramer, H.J., Backer, A., Vernerova, Z., Eis, V., Cervenka, L., Certikova Chabova, V., Teasr, V., Vaneckova, I., submitted for publication. Late onset endothelin-A receptor blockade substantially improves survival rate in homozygous hypertensive Ren-2 Rats. Hypertension. Ortmann, 2004, Role of podocytes for reversal of glomerulosclerosis and proteinuria in the aging kidney after endothelin inhibition, Hypertension, 44, 974, 10.1161/01.HYP.0000149249.09147.b4 Rossi, 2000, Blockade of angiotensin II type 1 receptor and not of endothelin receptor prevents hypertension and cardiovascular disease in transgenic (mREN2)27 rats via adrenocortical steroid-independent mechanisms, Arterioscler. Thromb. Vasc. Biol., 20, 949, 10.1161/01.ATV.20.4.949 Rothermund, 2003, Renal damage is not improved by blockade of endothelin receptors in primary renin-dependent hypertension, J. Hypertens., 21, 2389, 10.1097/00004872-200312000-00028 Rothermund, 2003, Nephroprotective effects of the endothelin ET(A) receptor antagonist darusentan in salt-sensitive genetic hypertension, Eur. J. Pharmacol., 468, 209, 10.1016/S0014-2999(03)01714-X Roux, 1999, Endothelin antagonism with bosentan: a review of potential applications, J. Mol. Med., 77, 364, 10.1007/s001090050363 Saam, 2003, Effect of endothelin blockade on early cardiovascular remodeling in the one-clip-two-kidney hypertension of the rat, Kidney Blood Press Res., 26, 325, 10.1159/000073938 Salani, 2002, ABT-627, a potent endothelin receptor A antagonist, inhibits ovarian carcinoma growth in vitro, Clin. Sci. (Lond.), 103, 318S, 10.1042/CS103S318S Vaneckova, 2005, Early endothelin-A receptor blockade decreases blood pressure and ameliorates end-organ damage in homozygous Ren-2 rats, Hypertension, 46, 969, 10.1161/01.HYP.0000173426.06832.b5 Weinberger, 1996, Salt sensitivity: does it play an important role in the pathogenesis and treatment of hypertension?, Curr. Opin. Nephrol. Hypertens., 5, 205, 10.1097/00041552-199605000-00003 Whitworth, 1995, Endothelin in the kidney in malignant phase hypertension, Hypertension, 26, 925, 10.1161/01.HYP.26.6.925 Yagil, 2002, Proteinuria and glomerulosclerosis in the Sabra genetic rat model of salt susceptibility, Physiol. Genomics, 9, 167, 10.1152/physiolgenomics.00014.2002 Yanagisawa, 1988, A novel potent vasoconstrictor peptide produced by vascular endothelial cells, Nature, 332, 411, 10.1038/332411a0 Zicha, 1999, Ontogenetic aspects of hypertension development: analysis in the rat, Physiol. Rev., 79, 1227, 10.1152/physrev.1999.79.4.1227