Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial

Azzawi, 1990, Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma, Am Rev Respir Dis, 142, 1407, 10.1164/ajrccm/142.6_Pt_1.1407

Djukanovic, 1990, Mucosal inflammation in asthma, Am Rev Respir Dis, 142, 434, 10.1164/ajrccm/142.2.434

Laitinen, 1993, Airway mucosal inflammation even in patients with newly diagnosed asthma, Am Rev Respir Dis, 147, 697, 10.1164/ajrccm/147.3.697

Boulet, 1995, Airway responsiveness and bronchial-wall thickness in asthma with or without fixed airflow obstruction, Am J Respir Crit Care Med, 152, 865, 10.1164/ajrccm.152.3.7663797

Stewart, 1993, Airway wall remodelling in asthma: a novel target for the development of anti-asthma drugs, Trends Pharmacol Sci, 14, 275, 10.1016/0165-6147(93)90130-C

Kuwano, 1993, Small airway dimensions in asthma and in chronic obstructive pulmonary disease, Am Rev Respir Dis, 148, 1220, 10.1164/ajrccm/148.5.1220

Peat, 1987, Rate of decline of lung function in subjects with asthma, Eur J Respir Dis, 70, 171

Lange, 1998, A 15-year follow up study of ventilatory function in adults with asthma, N Engl J Med, 339, 1194, 10.1056/NEJM199810223391703

Haahtela, 1991, Comparison of a beta 2-agonist, terbutaline with an inhaled corticosteroid, budesonide in newly detected asthma, N Engl J Med, 325, 388, 10.1056/NEJM199108083250603

Haahtela, 1994, Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma, N Engl J Med, 331, 700, 10.1056/NEJM199409153311103

Van Essen-Zandvliet, 1992, Effects of 22 months of treatment with inhaled corticosteroids and/or beta2-agonists on lung function, airway responsiveness and symptoms in children with asthma, Am Rev Respir Dis, 146, 547, 10.1164/ajrccm/146.3.547

Kerstjens, 1992, A comparison of bronchodilator therapy with or without inhaled corticosteroid therapy for obstructive airways disease, N Engl J Med, 327, 1413, 10.1056/NEJM199211123272003

Juniper, 1990, Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in nonsteroid-dependent asthmatics, Am Rev Respir Dis, 142, 832, 10.1164/ajrccm/142.4.832

Suissa, 2000, Low-dose inhaled corticosteroids and the prevention of death from asthma, N Engl J Med, 343, 332, 10.1056/NEJM200008033430504

Agertoft, 1994, Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children, Respir Med, 88, 373, 10.1016/0954-6111(94)90044-2

Selroos, 1995, Effect of early vs late intervention with inhaled corticosteroid in asthma, Chest, 108, 1228, 10.1378/chest.108.5.1228

Szefler, 2000, Long-term effects of budesonide or nedocromil in children with asthma, N Engl J Med, 343, 1054, 10.1056/NEJM200010123431501

1995

1997, The British guidelines on asthma management, Thorax, 52, S1

1997

Pauwels, 2001, The inhaled steroid treatment as regular therapy in early asthma (START) study: rationale and design, Control Clin Trials, 22, 405, 10.1016/S0197-2456(01)00144-1

Brown, 1999

Pauwels, 1997, Effect of inhaled formoterol and budesonide on exacerbations of asthma, N Engl J Med, 337, 1405, 10.1056/NEJM199711133372001

O'Byrne, 1996, Efficacy and cost benefit of inhaled corticosteroids in patients considered to have mild asthma in primary care, Can Respir J, 3, 169, 10.1155/1996/105967

Roorda, 1996, Prognostic factors for the outcome of childhood asthma in adolescence, Thorax, 51, S7, 10.1136/thx.51.Suppl_1.S7

Allen, 1998, Growth in asthmatic children treated with fluticasone propionate, J Pediatr, 132, 472, 10.1016/S0022-3476(98)70023-X

Agertoft, 2000, Effect of long-term treatment with inhaled budesonide on adult height in children with asthma, N Engl J Med, 343, 1064, 10.1056/NEJM200010123431502

Doull, 1995, Growth of prepubertal children with mild asthma treated with inhaled beclomethasone dipropionate, Am J Respir Crit Care Med, 151, 1715, 10.1164/ajrccm.151.6.7767512

Tinkelman, 1993, Aerosol beclomethasone dipropionate compared with theophylline as primary treatment of chronic, mild to moderately severe asthma in children, Pediatrics, 92, 64, 10.1542/peds.92.1.64

1998